Longitudinal association between muscle strength and depression in middle-aged and older adults: A 7-year prospective cohort study in China

Bao, Min; Chao, Jianqian; Sheng, Mingxin; Cai, Ruixue; Zhang, Na; Chen, Hongling

doi:10.1016/j.jad.2022.01.036

Cited by 28 publications

(21 citation statements)

References 30 publications

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“…However, the study used data from SAGE 2 a decade ago and ultimately did not find any gender differences in the association between low grip strength and depressive symptoms. A 7-year prospective cohort study in China sought to investigate whether insufficient muscle strength contributes to a higher incidence of depression (Bao et al, 2022). This study, with participants who were middle-aged and elderly people over the age of 45, was a small sample study, and the influence of confounding factors such as gender and exercise were ignored.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Grip Strength and Depression Among Adults Aged 60 Years and Older: A Large-Scaled Population-Based Study From the Longitudinal Aging Study in India

Wang

Zhou²,

Qiu³

et al. 2022

Front. Aging Neurosci.

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BackgroundThe association between grip strength and depression in elderly individuals in low- and middle-income countries (LMICs) has rarely been studied. This study aims to explore the relevance of grip strength and depression in the elderly population using data from a national large-scale population.MethodsThis study was conducted using data from seniors over 60 years old in wave 1 of the Longitudinal Aging Study in India (LASI). Grip strength is the maximum of three measurements by the dynamometer. Depression symptoms were assessed using 10 items on the Center for Epidemiologic Studies Depression Scale (CESD-10) with a 10-point boundary. Multivariate linear regression analysis, non-linear analysis, subgroup analysis, interaction tests and sensitivity analysis were performed.ResultsThere were 27,343 participants in this study, including 19,861 participants with low grip strength and 7,482 participants with normal grip strength. The results revealed that grip strength and depression were negatively correlated in elderly individuals after adequate adjustment for confounding factors [odds ratio (OR) = 1.237, 95% confidence interval (CI) 1.172–1.305, p < 0.00001]. The results remained stable after adjusting for all confounding factors (OR = 1.090, 95% CI 1.030–1.155, p = 0.00307). Regression analysis showed that physical activity (PA), comorbidities and cognition may have an impact on the correlation between grip strength and depression symptoms. Smooth curve fit suggested that grip strength and depressive symptoms were linearly related. The interaction test results of gender in the relationship between grip strength and depression were significant (p for interaction < 0.05).ConclusionGrip strength and depression were negatively correlated in older Indians, and larger prospective studies are needed in the future to determine this association.

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Section: Discussionmentioning

confidence: 99%

The Association Between Grip Strength and Depression Among Adults Aged 60 Years and Older: A Large-Scaled Population-Based Study From the Longitudinal Aging Study in India

Wang

Zhou²,

Qiu³

et al. 2022

Front. Aging Neurosci.

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“…Furthermore, the antidepressant effects of muscle-strengthening PA were shown to be independent of aerobic PA. In a seven-year follow-up study involving 228 middle-aged and older adults without depression at baseline, Bao et al [ 29 ] examine the association between handgrip strength and the 5 times sit-to-stand test (5STST) and incident depression. That study shows that greater handgrip strength at baseline was associated with a lower seven-year incident depression, while poor 5STST at baseline was an independent predictor of seven-year incident depression.…”

Section: Discussionmentioning

confidence: 99%

Relationship between physical activity and depressive symptoms in older Korean adults: moderation analysis of muscular strength

2022

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Background This population-based cross-sectional study examined the associations between physical activity (PA) and lower body muscle strength (LBMS) with late-life depression in a representative sample of older Korean adults aged 65 years and older. Methods The data used in the current study (n = 10,097/60% women) were extracted from the 2020 Korea Longitudinal Study on Aging, which is a nationwide population-based survey conducted in Korea. Depressive symptoms were assessed with the Geriatric Depression Scale Short-Form. PA and LBMS were evaluated with a self-reported questionnaire and the 5 times sit-to-stand test, respectively. Covariates include age, gender, body mass index, education level, smoking status, alcohol intake, and comorbidity. Results Insufficient PA had higher odds of depression (odds ratio [OR] = 1.201, 95% confidence interval [CI] = 1.035–1.393, p = 0.016), even after adjustments for all covariates, compared to sufficient PA. Poor LBMS had higher odds of depression (OR = 2.173, 95% CI = 1.821–2.593, p < 0.001), even after adjustments for all covariates, compared to good LBMS. Particularly, a significant moderation effect of LBMS on the relationship between PA and depressive symptoms was observed (β = 0.3514 and 95% CI = 0.1294 ~ 0.5733, p < 0.001). Individuals with poor LBMS had a greater odd of depression associated with physical inactivity compared to their counterparts with good LBMS. Conclusions The results of this study support the importance of promoting muscular strength through regular exercise as a preventive strategy against late-life depression in Korean adults.

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“…The authors assessed depressive symptoms and cognition at baseline and 1-year follow-up and showed that depressive symptoms at baseline predicted cognitive decline, but not vice versa—indicating that depression is a potential risk factor for cognitive impairment. By conducting a 7-year prospective cohort study involving 17,596 Chinese adults aged 45 years and older, Bao et al [ 44 ] showed that along with handgrip strength, five-times sit-to-stand test performance was an independent predictor of depression. Taken together, the findings of the current and previous studies suggest that the cognitive benefit of PA combined with muscle strength is associated with its anti-depressant effect, although the underlying mechanisms remain to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Late-Life Depression and Cognitive Function in Older Korean Adults: A Moderation Analysis of Physical Activity Combined with Lower-Body Muscle Strength

Kong

Kang

2022

IJERPH

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Background: This study examined the relationship of physical activity (PA) combined with lower-body muscle strength to late-life depression and cognitive impairment in 10,097 participants (6062 females) ≥ 65 years of age. Methods: Exposures were PA, sit-to-stand test (STST), and depressive symptoms. Outcome was cognitive performance. Results: Depressed individuals had an increased risk of mild cognitive impairment (MCI; odds ratio (OR), adjusted OR = 1.845 and 95% confidence interval (CI) = 1.580–2.154, p < 0.001) compared with non-depressed individuals. Individuals who had insufficient PA and a poor STST and either insufficient PA or a poor STST had an increased risk of MCI (adjusted OR = 1.329 and 95% CI = 1.209–1.46, p < 0.001 and adjusted OR = 2.822 and 95% CI = 2.488–3.200, p < 0001, respectively) compared with individuals who had sufficient PA and a good STST. A significant moderation effect of PA combined with lower-body muscle strength on the relationship between depression and cognitive function was observed (β = −1.3923; 95% CI = −2.1505 to −0.6341, p < 0.003). Conclusions: The negative effect of late-life depression on cognitive function was incremental in the order of sufficient PA and a good STST, insufficient PA or a poor STST, and insufficient PA and a poor STST.

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Longitudinal association between muscle strength and depression in middle-aged and older adults: A 7-year prospective cohort study in China

Cited by 28 publications

References 30 publications

The Association Between Grip Strength and Depression Among Adults Aged 60 Years and Older: A Large-Scaled Population-Based Study From the Longitudinal Aging Study in India

The Association Between Grip Strength and Depression Among Adults Aged 60 Years and Older: A Large-Scaled Population-Based Study From the Longitudinal Aging Study in India

Relationship between physical activity and depressive symptoms in older Korean adults: moderation analysis of muscular strength

The Relationship between Late-Life Depression and Cognitive Function in Older Korean Adults: A Moderation Analysis of Physical Activity Combined with Lower-Body Muscle Strength

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