Longitudinal Association between Uric Acid and Incident Sarcopenia

Zhou, Shengliang; Wu, Limin; Si, Haibo; Shen, Bin

doi:10.3390/nu15143097

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…Moreover, our findings suggested a significant association between LLM and an increased susceptibility to hyperuricemia. This findings aligns with research implemented by Zhou et al ( 34 ), which identified a negative relationship between sarcopenia and uric acid levels in middle-aged and older Chinese individuals. Similarly, two other cross-sectional studies also demonstrated an association between hyperuricemia and reduced skeletal muscle mass ( 35 ) and muscle strength ( 36 ).…”

Section: Discussionsupporting

confidence: 92%

The agreement of low lean mass with obesity using different definitions and its correlation with hyperuricemia

Xiao,

Hu,

Xie

et al. 2024

Front. Nutr.

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BackgroundThe agreement on the identification of sarcopenic obesity remains elusive, and its association with hyperuricemia remains unestablished. This study sought to evaluate the agreement of low lean mass (LLM) with obesity and its correlation with hyperuricemia.MethodsA total of 25,252 study participants, comprising 4,597 individuals with hyperuricemia, were obtained from the National Health and Nutrition Examination Survey spanning the years 1999–2006 and 2011–2018. LLM with obesity was characterized by the coexistence of LLM, determined by the ratio of appendicular lean mass to body mass index (BMI), and three categories of obesity including BMI, body fat percentage (BF%), and waist circumference (WC). We employed Cohen’s kappa to evaluate the agreement among the different diagnostic criteria and implemented survey multiple logistic regression and stratified analyses to explicate the connection between LLM with obesity and the risk of hyperuricemia.ResultsWhen defining obesity using BF%, BMI, and WC, the prevalence of LLM with obesity varied from 6.6 to 10.1%, with moderate-to-strong agreement. In the fully adjusted model, individuals with LLM or any of the three types of obesity exhibited notably elevated odds of developing hyperuricemia. Likewise, participants with LLM and obesity had 2.70 (LLM + BMI), 2.44 (LLM + BF%), and 3.12 (LLM + WC) times the risk of hyperuricemia, respectively, compared with healthy individuals. The association between LLM with obesity and hyperuricemia remained stable and significant across different age and sex subgroups.ConclusionWhen employing the three definitions of obesity, the incidence of LLM with obesity was not high, and the diagnostic agreement was relatively good. The participants with LLM and obesity exhibited an increased risk of hyperuricemia.

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Section: Discussionsupporting

confidence: 92%