Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes

Kop, Willem J.; Seliger, Stephen L.; Fink, Jeffrey C.; Katz, Ronit; Odden, Michelle C.; Fried, Linda F.; Rifkin, Dena E.; Sarnak, Mark J.; Gottdiener, John S.

doi:10.2215/cjn.03840510

Cited by 74 publications

(90 citation statements)

References 57 publications

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“…In the largest prospective CKD cohort to date, Fischer et al (34) found that depressive symptoms in the Chronic Renal Insufficiency Cohort Study were associated with a 21% higher risk of CKD progression over 5 years. However, the Cardiovascular Health Study (CHS) did not find an association between depressive symptoms and incident ESRD in their community-based cohort of elderly participants (17). This discrepancy may be related to the low prevalence of CKD in the study population in the CHS and, therefore, a lower incidence of ESRD (,2%) compared with the CKD cohorts in the other studies.…”

Section: Discussionmentioning

confidence: 94%

“…However, these studies were conducted in patients with a high likelihood of progression to ESRD because of preexisting CKD. In contrast, depressive symptoms were not predictive of incident ESRD in the Cardiovascular Health Study, a community-based cohort of individuals with a low likelihood of ESRD incidence (17). These discrepancies in findings may be attributable to differences in the underlying study populations, baseline levels of CKD, participant risk for ESRD, and definitions of ESRD.…”

Section: Introductionmentioning

confidence: 87%

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Associations between Depressive Symptoms and Incident ESRD in a Diabetic Cohort

Weiss²,

Ding

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Comorbid major depression is associated with adverse health outcomes in patients with diabetes, but little is known regarding its associations with long-term renal outcomes in this population. Furthermore, the impact of minor depression on renal outcomes is not known. This study evaluated associations between depressive symptoms and risk of incident ESRD in a diabetic cohort.Design, setting, participants, & measurements In this prospective, observational cohort study, 3886 ambulatory adults with diabetes were recruited from primary care clinics of a large health maintenance organization in the state of Washington. Demographics, laboratory data, depressive symptoms (based on the Patient Health Questionnaire-9), and patterns of diabetes self-care were collected. Participants were considered depressed if they had the required number of depressive symptoms ($5 for major or 2-4 for minor depressive symptoms), including depressed mood or anhedonia, .50% of the time for $2 weeks and a Patient Health Questionnaire-9 score$10 for major and $5 for minor depressive symptoms. Risk of incident ESRD was estimated using Cox proportional hazards regression, with predialysis death as a competing risk.Results During a median follow-up of 8.8 years, 87 patients (2.2%) developed ESRD. Major depressive symptoms were associated with a higher risk of incident ESRD (hazard ratio, 1.85; 95% confidence interval, 1.02 to 3.33) after adjusting for age, sex, race/ethnicity, marital status, education, smoking, body mass index, diabetes duration, hemoglobin A1c, baseline kidney function, microalbuminuria, hypertension, renin-angiotensin system blockers, and adherence to diabetes self-care. Minor depressive symptoms were not significantly associated with incident ESRD (hazard ratio, 1.08; 95% confidence interval, 0.52 to 2.25).Conclusion Major depressive symptoms, but not minor depressive symptoms, were associated with a higher risk of incident ESRD over 10 years. Additional studies are needed to determine whether treatment for depression can improve renal outcomes in patients with diabetes.Clin J Am Soc Nephrol 9: 920-928, 2014.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 87%

Associations between Depressive Symptoms and Incident ESRD in a Diabetic Cohort

Weiss²,

Ding

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Several of these problems individually have been shown to be associated with kidney disease (15)(16)(17). For example, an association between kidney disease and cognitive impairment has been consistently shown in previous studies (18)(19)(20).…”

Section: Introductionmentioning

confidence: 69%

“…In a previous analysis of the REGARDS Study, an 11% increase in the odds of prevalent cognitive impairment was shown for every 10-ml/min per 1.73 m 2 incremental decrease in eGFR (18). Depressive symptoms have also been evaluated in association with reduced eGFR (16). Exhaustion, a key component of the frailty phenotype, has been reported to be more prevalent at lower levels of reduced eGFR (26).…”

Section: Discussionmentioning

confidence: 99%

Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD

Bowling

Booth²,

Gutiérrez³

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives The term "nondisease-specific" has been used to describe problems that cross multiple domains of health and are not necessarily the result of a single underlying disease. Although individuals with reduced eGFR and elevated albumin-to-creatinine ratio have many comorbidities, the prevalence of and outcomes associated with nondisease-specific problems have not been well studied.Design, setting, participants, & measurements Participants included 3557 black and white United States adults $75 years of age from the Reasons for Geographic and Racial Differences in Stroke Study. Nondisease-specific problems included cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy. Hazard ratios for mortality over a median (interquartile range) of 5.4 (4.2-6.9) years of follow-up associated with one, two, or three to six nondisease-specific problems were calculated and stratified by eGFR ($60, 45-59, and ,45 ml/min per 1.73 m 2 ) and separately, albumin-to-creatinine ratio (,30, 30-299, and $300 mg/g). Secondary outcomes included hospitalizations and emergency department visits over 1.8 (0.7-4.0) and 2.3 (0.9-4.7) years of follow-up, respectively.Results The prevalence of nondisease-specific problems was more common at lower eGFR and higher albuminto-creatinine ratio levels. Within each eGFR and albumin-to-creatinine ratio strata, the risk for mortality was higher among those with a greater number of nondisease-specific problems. For example, among those with an eGFR=45-59 ml/min per 1.73 m 2 , the multivariable adjusted hazard ratios (95% confidence intervals) for mortality associated with one, two, or three to six nondisease-specific problems were 1.17 (0.78 to 1.76), 1.95 (1.24 to 3.07), and 2.44 (1.39 to 4.27; P trend ,0.001). Risk for hospitalization and emergency department visits was higher among those with more nondisease-specific problems within eGFR and albumin-to-creatinine ratio strata.Conclusions Among older adults, nondisease-specific problems commonly co-occur with reduced eGFR and elevated albumin-to-creatinine ratio. Identification of nondisease-specific problems may provide mortality risk information independent of measures of kidney function.

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“…Some other investigators observed that serum urea, creatinine and uric acid levels were significantly increased after 2 weeks treatment with oxidative stress induced by mercuric chloride(0.5 mg/ kg bw) 9 .In a longitudinal study (5days to 11 years)it has been shown that the individuals with depressive symptoms may develop rapid declines in kidney function and hospitalization occur with acute kidney injuryduring follow-up 10 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

Jahan¹,

Akhter

Sultana

2017

J Bangladesh Soc Physiol

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Background: Depression is associated with stressful condition which may cause kidney damage. Oyster mushroom (plurotus florida) may have free radical scavenging activity thereby can be used for the prevention and treatment for kidney damage. Objective: to observe the effect of oyster mushroom (plurotus florida) on kidney in restraint stress induced depressed rats. Methods: This experimental study was conducted from July 2012 to June 2013 in the Department of Physiology, Sir Salimullah Medical College( SSMC), Mitford, Dhaka. Thirty Wister albino male rats, aged 90 to 100 days, weighing 150 to 180g (initial body weight) were used in the present study. Then they were divided into Group I (Control group, without mushroom n=20) and Group II (Experimental group, depressed rats supplemented with mushroom n=10). Control group without mushroom again subdivided into Group Ia,( baseline control n=10) and Group Ib (depressed control n=10) . All groups of animals were received basal diet for 28 consecutive days started from the 1 st day of the study period. Group Ib (depressed control) and group II (depressed mushroom supplemented) were housed under controlled condition in rat immobilizer (made up of steel wire, measuring 9´´ x 2.75´´ of light weight) for 6 hour/day for 28 days for the development of stress induced depression. In addition, only group II received oyster mushroom extract (200 mg/kg body weight, orally) for the same period. One rat of Group Ib (depressed control) was expired after 10 days for unknown cause. All 29 rats were sacrificed on day 30. Then blood sample and kidneys specimen were collected. Initial (initial bw ) and final body weights (final bw) were measured. Then estimation of blood glucose and serum urea levels were done by standard laboratory technique. Histology of kidney was done by standard laboratory procedure. Statistical analysis was done by using SPSS windows Version -16. One way ANOVA and Bonferroni tests were done as applicable. Results: In this study blood glucose level and serum urea level was significantly higher and abnormal histological structure was found in stress induced depressed rats. After taking mushroom extract for 28 days all the parameters were improved. Conclusion: From this study it can be concluded that oyster mushroom(Pleurotus florida) which is excellent edible and nutritious, may have renoprotective effect.

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Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes

Cited by 74 publications

References 57 publications

Associations between Depressive Symptoms and Incident ESRD in a Diabetic Cohort

Associations between Depressive Symptoms and Incident ESRD in a Diabetic Cohort

Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD

Effect of Oyster Mushroom on Kidney in Stress Induced Depressed Rats

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