Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial

García-Calzón, Sonia; Gea, Alfredo; Razquín, Cristina; Corella, Dolores; Lamuela‐Raventós, Rosa M.; Martínéz, J. Alfredo; Martínez-González, M Á; Zalba, Guillermo; Marti, Amelia

doi:10.1038/ijo.2013.68

Cited by 98 publications

(78 citation statements)

References 34 publications

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“…Por otra parte, muchos de los desequilibrios metabólicos de la obesidad (por ejemplo, glucemia, lipemia, etc.) dan lugar a una disfunción de órganos en una forma que se asemeja al proceso de envejecimiento acelerado (69,74).…”

Section: Introductionunclassified

“…En un estudio longitudinal con dieta mediterránea (PREDIMED), se mostró por primera vez que una disminución en el riesgo de obesidad está asociado a una longitud telómerica más larga tras una intervención con dieta mediterránea durante cinco años (74). El ritmo de envejecimiento y el equilibrio del peso corporal, por tanto, están interconectados (70).…”

Section: Introductionunclassified

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Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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Section: Introductionunclassified

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

View full text Add to dashboard Cite

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“…Regular physical activity augments the physiological antioxidant response (28,29). Additionally, physical activity promotes energy expenditure and helps maintain energy balance; thus, being physically active may reduce obesity (43) and the associated levels of oxidative stress and inflammation (44). The extent of ROS damage to telomere DNA depends on a balance between factors that promote oxidative stress and those that augment antioxidative defense.…”

Section: Cancer Epidemiol Biomarkers Prev; 25(2) February 2016mentioning

confidence: 99%

The Influence of Alcohol Consumption, Cigarette Smoking, and Physical Activity on Leukocyte Telomere Length

Latifovic

Peacock

Massey

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Telomeres protect from DNA degradation and maintain chromosomal stability. Short telomeres have been associated with an increased risk of cancer at several sites. However, there is limited knowledge about the lifestyle determinants of telomere length. We aimed to determine the effect of three factors, known to be important in cancer etiology, on relative leukocyte telomere length (rLTL): alcohol consumption, smoking, and physical activity.Methods: This cross-sectional study included 477 healthy volunteers ages 20 to 50 years who completed a questionnaire and provided a fasting blood sample. Multiplex quantitative realtime PCR (qPCR) was used to measure rLTL. Regression coefficients were calculated using multiple linear regression while controlling for important covariates.Results: There was no association between alcohol consumption and rLTL. Daily smokers and those in the middle and lower

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“…Leukocyte telomere length, which is a widely used biomarker of aging, has been found to be negatively correlated with body mass index (BMI) (3)(4)(5)(6)(7). Although the observed correlation between BMI and telomere length is relatively weak (r = 0.12) (4), it is remarkable that these studies demonstrated that BMI is associated with an age acceleration effect in blood.…”

mentioning

confidence: 99%

Obesity accelerates epigenetic aging of human liver

Horvath

Erhart²,

Brosch

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

662

643

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Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10 −4 in dataset 1 and r = 0.42, P = 1.2 × 10 −4 in dataset 2). On average, epigenetic age increased by 3.3 y for each 10 BMI units. The detected age acceleration in liver is not associated with the Nonalcoholic Fatty Liver Disease Activity Score or any of its component traits after adjustment for BMI. The 279 genes that are underexpressed in older liver samples are highly enriched (1.2 × 10 −9 ) with nuclear mitochondrial genes that play a role in oxidative phosphorylation and electron transport. The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.obesity | epigenetics | aging | biological age | DNA methylation

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Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial

Abstract: Background: Telomeres are nucleoprotein structures that protect the ends of eukaryote

Cited by 98 publications

References 34 publications

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

The Influence of Alcohol Consumption, Cigarette Smoking, and Physical Activity on Leukocyte Telomere Length

Obesity accelerates epigenetic aging of human liver

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