In many contexts worldwide, most people grow up with one or more siblings. The current paper reviews research on sibling relationship quality (closeness, communication, and conflict) in adolescence and young adulthood in four different contexts: primarily White North American and European samples (132 articles reviewed); ethnic minority families (26 articles reviewed); China (6 articles reviewed); and when one sibling has a disability (21 articles reviewed). Where the literature was available, within each context we addressed five questions: how does sibling relationship quality change from adolescence through young adulthood, how are demographic and structural characteristics linked to sibling relationship quality, how is sibling relationship quality linked to adjustment and behavior, how are familial relationships and processes linked to sibling relationship quality, and how is sibling relationship quality linked to non-familial relationships. Included articles were published between 2001 and 2021 and included aspects of sibling closeness, communication, or conflict in adolescence or young adulthood. Across all contexts, individual (e.g., gender) and dyadic characteristics (e.g., gender composition, birth order) play a role in siblings’ relationship qualities. In several contexts, the current literature suggests that sibling closeness and communication are linked to positive development, well-being, and healthy relationships with other social partners. In multiple contexts, sibling conflict is linked to poorer well-being and negative relationships with other social partners. These broad patterns, however, are qualified by each context and often multiple moderators.