Longitudinal associations between low morning cortisol in infancy and anger dysregulation in early childhood in a <scp>CPS</scp>‐referred sample

Frost, Allison; Jelinek, Caitlin; Bernard, Kristin; Lind, Teresa; Dozier, Mary

doi:10.1111/desc.12573

Cited by 12 publications

(7 citation statements)

References 55 publications

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“…Increased stress hormones have long been associated with both initiating infant neurobehavioral pathology and its expression 11 , and animal and human research has shown stress hormones are associated with long-term outcomes of early life trauma 18 . For this reason, we next leveraged the power of our animal model to test if there is a causal link between stress hormone levels and the neurobehavioral deficits induced by scarcity-adversity treatment.…”

Section: Stress Hormone Reduction Rescues Maternal Regulation Of Pupsmentioning

confidence: 99%

“…6b; two-way ANOVA, rearing × drug, significant interaction (F (1,18) = 11.03, p = 0.004), main effects of drug (F (1,18) = 8.103, p = 0.011) and rearing (F (1,18) = 5.722, p = 0.028)]. Post hoc analyses showed that while saline-treated, adversity-reared pups showed a significant increase in atypical attachment behaviors a b .237, p = 0.005), attachment behavior did not differ between adversityreared pups treated with metyrapone and saline controls (t (18) = 0.31, p = 0.76). These behavioral changes were also reflected in pups' LFP recordings.…”

Section: Stress Hormone Reduction Rescues Maternal Regulation Of Pupsmentioning

confidence: 99%

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Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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The roots of psychopathology frequently take shape during infancy in the context of parentinfant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to attachment figures among infants who experienced adversity as a benchmark, we assessed rat pup cortical local field potentials (LFPs) and behaviors exposed to adversity in response to maternal rough and nurturing handling by examining its impact on pup separation-reunion with the mother. We show that during adversity, pup cortical LFP dynamic range decreased during nurturing maternal behaviors, but was minimally impacted by rough handling. During reunion, adversityexperiencing pups showed aberrant interactions with mother and blunted cortical LFP. Blocking pup stress hormone during either adversity or reunion restored typical behavior, LFP power, and cross-frequency coupling. This translational approach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of the mother, which can be used as an early biomarker of later-life pathology.

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Section: Stress Hormone Reduction Rescues Maternal Regulation Of Pupsmentioning

confidence: 99%

Section: Stress Hormone Reduction Rescues Maternal Regulation Of Pupsmentioning

confidence: 99%

Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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“…In 2016, over 670,000 American children were reported victims of child maltreatment (USDHHS, 2018). Maltreatment places children at increased risk for disorganized attachment (van IJzendoorn, Schuengel, & Bakermans-Kranenburg, 1999), disruptions in hypothalamic-pituitary-adrenal (HPA) axis functioning (Bernard, Butzin-Dozier, Rittenhouse & Dozier, 2010) and behavioral dysregulation (Frost, Jelinek, Bernard, Lind, & Dozier, 2017), as well as mental health disorders (e.g., LeTendre & Reed, 2017) and death due to chronic disease (Miller, Chen, & Parker, 2011) in adulthood. The psychological and physical burden of exposure to maltreatment highlights the need for early interventions to prevent maltreatment and alter developmental pathways to poor outcomes.…”

Section: Public Health Impact Of Child Abuse and Neglectmentioning

confidence: 99%

Novel Methods for Screening: Contributions from Attachment and Biobehavioral Catch-up

et al. 2018

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Preventative interventions are needed across the lifespan, including for children who have experienced maltreatment. However, interventions' effect sizes are typically smaller in real-world settings than in clinical trials. Identifying providers who are likely to implement interventions with fidelity could promote implementation outcomes through targeted allocation of training resources. This study tested two pre-training screening measures as predictors of provider fidelity to Attachment and Biobehavioral Catch-up (ABC), a preventative intervention for maltreated infants. One measure assessed valuing of attachment/openness, and the other used vignettes to assess initial skill in a key intervention component. In a sample of 42 providers across 197 sessions, both screening measures predicted future ABC fidelity, even when controlling for experience and education. These results support the development of screening measures for other interventions, suggesting approaches that target specific qualities and behaviors are likely to predict implementation fidelity.

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“…Intergenerational patterns of violence are well documented (Kwong et al, 2003), it is possible that HPA functioning is a mechanism by which witnessing violence in the parent generation is associated with aggression and violent behavior among offspring. Supporting this possibility, basal cortisol at a year of age is associated with anger dysregulation at 3 years (Frost et al, 2017), and basal cortisol is concurrently associated with peer reports of aggression at 10 years (Oberle et al, 2017).…”

Section: Discussionmentioning

confidence: 91%

Maternal witness to intimate partner violence during childhood and prenatal family functioning alter newborn cortisol reactivity

Parade

Newland

Bublitz

et al. 2019

Stress

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Witnessing intimate partner violence (IPV) during childhood is a risk factor for mental health problems across the lifespan. Less is known about the intergenerational consequences of witnessing IPV, and if the current family climate buffers intergenerational effects of witnessing violence. The mother's experience of witnessing IPV against her own mother during childhood, prenatal family dysfunction, and prenatal perceived stress were examined as predictors of offspring cortisol in the first month of life (N = 218 mother-infant dyads). Mothers reported on witnessing IPV in their childhoods, prenatal family dysfunction, and prenatal perceived stress in pregnancy. At 2 days and again at 1 month postpartum, infants engaged in a neurobehavioral exam to assess infant cortisol reactivity. Infants whose mothers witnessed IPV in childhood exhibited alterations in their baseline cortisol and their cortisol reactivity at one month of age, whereas family dysfunction during pregnancy was associated with baseline cortisol and cortisol reactivity at 2 days of age. Prenatal perceived stress was not associated with infant cortisol at 2 days or 1 month. Prenatal family dysfunction and perceived stress did not moderate effects of the mother's experience of witnessing IPV. Results support the view that maternal experiences in childhood and during pregnancy exert intergenerational effects on the HPA stress response system.

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Longitudinal associations between low morning cortisol in infancy and anger dysregulation in early childhood in a CPS‐referred sample

Cited by 12 publications

References 55 publications

Adverse caregiving in infancy blunts neural processing of the mother

Adverse caregiving in infancy blunts neural processing of the mother

Novel Methods for Screening: Contributions from Attachment and Biobehavioral Catch-up

Maternal witness to intimate partner violence during childhood and prenatal family functioning alter newborn cortisol reactivity

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