Longitudinal Associations Between Vision Impairment and the Incidence of Neuropsychiatric, Musculoskeletal, and Cardiometabolic Chronic Diseases

Kolli, Ajay; Seiler, Kristian; Kamdar, Neil; Lott, Lindsey B. De; Peterson, Mark D.; Meade, Michelle A.; Ehrlich, Joshua R.

doi:10.1016/j.ajo.2021.09.004

Cited by 14 publications

(12 citation statements)

References 47 publications

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“…The strength of our study includes the use of the NDRS in our analysis. VD is associated with an increased risk of DM [ 14 , 15 ], regardless of AMD pathogenesis. Visual impairment is associated with physical inactivity [ 40 , 41 , 42 ], which may have adverse consequences for people with VD.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, AMD is the leading cause of blindness in developed countries, particularly in patients over 60 years of age [ 2 ]. Visual disability (VD) is associated with a broad range of chronic conditions, including cardiometabolic, neuropsychiatric, and musculoskeletal disorders [ 14 , 15 ]. A nearly twofold risk of type 2 DM among people aged 65 or older with visual impairment was reported in a US claims database study [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Visual disability (VD) is associated with a broad range of chronic conditions, including cardiometabolic, neuropsychiatric, and musculoskeletal disorders [ 14 , 15 ]. A nearly twofold risk of type 2 DM among people aged 65 or older with visual impairment was reported in a US claims database study [ 14 ]. In addition, a recent prospective study highlighted the role of the neighborhood environment in DM risk in people with visual impairment [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study

et al. 2022

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Age-related macular degeneration (AMD) is a degenerative and progressive disease of the macula, the part of the retina that is responsible for central vision. AMD shares some risk factors with diabetes mellitus (DM), but little is known about the risk of DM in individuals with AMD. With the goal of establishing novel perspectives, this study aimed to investigate the association between AMD and the risk of DM using the Korean Nationwide Health Insurance Database. Individuals aged ≥ 50 years who underwent a national health screening program in 2009 were enrolled. Participants were categorized by the presence of AMD and visual disability (VD). The Cox hazard regression model was used to examine hazard ratios (HRs) of DM with adjustment for potential confounders. Stratified analyses by age, sex, and comorbidities (hypertension or dyslipidemia) were also performed. During a mean follow-up of 8.61 years, there were 403,367 (11.76%) DM incidences among the final 3,430,532 participants. The crude HR (95% confidence interval (CI)) was 1.16 (1.13–1.20) for AMD. After adjusting for potential confounders, AMD was associated with a 3% decreased risk of DM (aHR 0.97, 95% CI 0.95–1.00), but no significant association with the risk of DM was found in AMD with VD (aHR 1.03, 95% CI 0.93–1.14). In summary, we did not find an increased risk of DM in individuals with AMD. A 3% decreased risk of DM in patients with AMD is not clinically meaningful. Our study suggests that the association between AMD and the risk of DM is weak, considering the potential confounders. Further studies examining this association are needed to extend our knowledge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study

et al. 2022

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“…Globally, the number of people with blind or with moderate to severe visual impairment caused by macular disease is approximately 2.1 million 23 . Visual disability is associated with broad range of chronic conditions, including cardiometabolic, neuropsychiatric, and musculoskeletal disorders 24 – 26 . Therefore, we conducted a retrospective, nationwide, population-based cohort study to investigate the risk of ESRD in patients with AMD, considering the visual disability status.…”

Section: Introductionmentioning

confidence: 99%

Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up

Jung

Park

Jang

et al. 2023

Sci Rep

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Common etiologies between age-related macular degeneration (AMD) and kidney disease advocate a close link between AMD and end-stage renal disease (ESRD). However, the risk of ESRD in people with AMD was not reported. Here, we investigated the association between AMD and the risk of ESRD by using a nationwide, population-based cohort data in Korea. 4,206,862 participants aged 50 years or older were categorized by presence of AMD and visual disability. Risk of ESRD was the primary outcome. Cox regression hazard model was used to examine the hazard ratios (HRs) with adjustment for potential confounders. Stratified analyses by age, sex, baseline kidney function, and cardiometabolic comorbidities were performed. During the mean 9.95 years of follow-up, there were 21,759 incident ESRD events (0.52%). AMD was associated with 33% increased risk of ESRD (adjusted HR [aHR] 1.33, 95% confidence interval [CI] 1.24–1.44), and the risk was even higher when accompanied by visual disability (aHR 2.05, 95% CI 1.68–2.50) than when not (aHR 1.26, 95% CI 1.17–1.37). Age, baseline kidney function, and cardiometabolic comorbidities significantly interact between AMD and the risk of ESRD. Our findings have clinical implications on disease prevention and risk factor management of ESRD in patients with AMD.

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“…VI may contribute to adverse health outcomes by affecting biopsychosocial functioning [ 19 ]. Compared to the general population, PVIs are at higher risk of multimorbidity [ 20 , 21 , 22 ], mental health problems [ 23 , 24 , 25 ], falls, and resulting injuries [ 26 ]. Moreover, during the COVID-19 pandemic, it was also noted that PVIs perceive themselves as more vulnerable to infection [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Is Telemedicine in Primary Care a Good Option for Polish Patients with Visual Impairments Outside of a Pandemic?

Binder-Olibrowska

Wrzesińska

Godycki-Ćwirko

2022

IJERPH

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With the proliferation of telemedicine during the COVID-19 pandemic, attention began to turn to the risk of health disparities associated with its use among people with disabilities. Therefore, the present study investigates the level of interest in using teleconsultations (TCs) in primary healthcare among people with visual impairments (PVIs) and identifies their motivations and needs. A total of 219 Polish PVIs were surveyed using a combination of closed and open questions. About 50% of the respondents expressed interest in using TCs. The factor most closely related to the willingness to use TCs was age. The predominant reason for using TCs was to obtain a prescription or referral, and the most highlighted need was the possibility to choose between a TC and an in-person visit. The blind and poor-sighted participants differed in some regards. Our study indicates that TCs, under some conditions, may be a beneficial option for PVIs, and provides some directions for its effective implementation.

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Longitudinal Associations Between Vision Impairment and the Incidence of Neuropsychiatric, Musculoskeletal, and Cardiometabolic Chronic Diseases

Cited by 14 publications

References 47 publications

Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study

Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study

Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up

Is Telemedicine in Primary Care a Good Option for Polish Patients with Visual Impairments Outside of a Pandemic?

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