Longitudinal associations of cannabis, depression, and anxiety in heterosexual and LGB adolescents.

London-Nadeau, Kira; Rioux, Charlie; Parent, Sophie; Vitaro, Frank; Côté, Sylvana M.; Boivin, Michel; Tremblay, Richard E.; Séguin, Jean R.; Castellanos‐Ryan, Natalie

doi:10.1037/abn0000542

Cited by 13 publications

(8 citation statements)

References 72 publications

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“…Regarding methods, most longitudinal studies use summary data from one developmental period, such as cannabis use during adolescence, to predict an outcome at another developmental period, such as depressive symptoms in young adulthood. Prior research has also utilized methods such as cross-lagged panel models to assess time-lagged associations between cannabis and depression, with mixed results [9,10]. Unfortunately, cross-lagged panel models provide estimates that are an amalgam of within-and between-person variance and do not account for change, which makes results difficult to interpret [11,12].…”

Section: Introductionmentioning

confidence: 99%

Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences

et al. 2023

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Background and aims Although the co‐occurrence of cannabis and depression is well established, less is known about the temporal sequence of cannabis use and depression. The present study had three main aims: to test a symptom‐driven pathway in which depression may drive increases in cannabis use, to test a substance‐induced pathway in which cannabis use may drive increases in depression and to assess a shared vulnerability model assessing associations between individuals who have (and have not) experienced adverse childhood experiences (ACEs). Design Data are from an ongoing, longitudinal, cohort study (n = 2234). Data were set up in an accelerated longitudinal design from age 17 to 24 years. Setting Initial sample was recruited from Southern California, USA. The majority of participants still live in Southern California. Participants On average, participants were aged 18 years at wave 8, with more than half identifying as female (54.3%; n = 1350). Most participants identified as Hispanic (1127; 45.4%), followed by non‐Hispanic white (510; 20.5%), Asian (503; 20.2%), multi‐racial/other (284; 11.4%) and non‐Hispanic black (60; 2.2%). Measurements Primary outcomes were past‐month days of cannabis use and depression symptoms [patient health questionnaire (PHQ)‐8]. The Adverse Childhood Experiences scale was used as our main grouping measure. Findings In the full sample, we showed that prior levels of depression symptoms were associated with a decrease in cannabis use [opposite to the proposed symptom driven model; B = −0.33 (−0.58, −0.09)]. Dynamic coupling parameters noted individuals who evidenced greater increases in cannabis use between two prior ages reported greater increases in depressive symptoms between subsequent ages [support for a substance‐induced pathway; B = 0.53 (0.18, 0.89)]. Similar to the overall sample, for those who had not experienced ACEs, as cannabis use increased we saw a steady increase in depression [support for a substance induced pathway; B = 0.14 (0.04, 0.29)]. However, for those who experienced ACEs, as cannabis use increased we saw a consistent decrease in depression [opposite to the proposed substance‐induced pathway; B = −0.18 (−0.28, −0.08)]. Conclusion There is mixed support for both symptom‐driven and substance‐induced pathways between cannabis use and depression.

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Section: Introductionmentioning

confidence: 99%

Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences

et al. 2023

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“…Among these studies, 22 identified a significant temporal association between baseline cannabis use and subsequent depression. Cannabis use was a significant predictor of adulthood depression across 12 sample sets following adolescents ( 20 , 34 , 42 , 59 , 60 , 66 , 70 , 74 , 78 , 82 , 84 , 89 ). In a sample of LGB and heterosexual adolescents, London-Nadeau and colleagues observed that cannabis use at age 13 predicted depression symptoms at ages 15 and 17 among LGB participants only ( 70 ).…”

Section: Resultsmentioning

confidence: 99%

“…Cannabis use was a significant predictor of adulthood depression across 12 sample sets following adolescents ( 20 , 34 , 42 , 59 , 60 , 66 , 70 , 74 , 78 , 82 , 84 , 89 ). In a sample of LGB and heterosexual adolescents, London-Nadeau and colleagues observed that cannabis use at age 13 predicted depression symptoms at ages 15 and 17 among LGB participants only ( 70 ). However, a bidirectional relationship was also identified among LGB adolescents, where baseline depressive scores predicted subsequent cannabis use.…”

Section: Resultsmentioning

confidence: 99%

Cannabis use and mood disorders: a systematic review

Sorkhou,

Dent,

George

2024

Front. Public Health

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BackgroundProblematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use.ObjectivesWe aimed to (1) systematically evaluate cross-sectional and longitudinal studies investigating the interplay between cannabis use, cannabis use disorder (CUD), and the occurrence of mood disorders and symptoms, with a focus on major depressive disorder (MDD) and bipolar disorder (BD) and; (2) examine the effects of cannabis on the prognosis and treatment outcomes of MDD and BD.MethodsFollowing PRISMA guidelines, we conducted an extensive search for English-language studies investigating the potential impact of cannabis on the development and prognosis of mood disorders published from inception through November 2023, using EMBASE, PsycINFO, PubMed, and MEDLINE databases.ResultsOur literature search identified 3,262 studies, with 78 meeting inclusion criteria. We found that cannabis use is associated with increased depressive and manic symptoms in the general population in addition to an elevated likelihood of developing MDD and BD. Furthermore, we observed that cannabis use is linked to an unfavorable prognosis in both MDD or BD.DiscussionOur findings suggest that cannabis use may negatively influence the development, course, and prognosis of MDD and BD. Future well-designed studies, considering type, amount, and frequency of cannabis use while addressing confounding factors, are imperative for a comprehensive understanding of this relationship.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023481634.

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“…A longitudinal research study conducted in the United States from participants aged 12–32 years attempted to find the causal relationship between depression and cannabis use and found that it was bidirectional and more common among sexual minority groups such as LGBTQI groups [ 37 ]. This finding was supported by another cross-sectional study conducted in the United States consisting of 204,102 individuals aged 12–17 years [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Cannabis Use and Its Impact on Mental Health in Youth in Australia and the United States: A Scoping Review

Baral,

Hanna,

Chimoriya

et al. 2024

Epidemiologia

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Cannabis is a widely used substance among the youth population, with an estimated 2.8% currently smoking cannabis. Its popularity is growing due to the perception of its harmless nature and lack of dependence. However, this increase in use has been linked to mental health issues, especially since its partial decriminalisation in some part of the United States and Australia. The objective of this scoping review was to investigate the mental health impact of cannabis use among young people in Australia and the United States. A scoping review was conducted according to the Joanna Briggs Institute (JBI) protocol, and articles were searched from ProQuest Central and EBSCO Host (MEDLINE and CINAHL databases). A total of 24 articles were analysed, including systematic reviews, meta-analyses, and cohort, longitudinal, and cross-sectional studies. The findings indicate that cannabis use is associated with depression, psychosis, suicide, cannabis use disorder, dependence, decline in cognitive function, and the development of externalising behaviour, particularly attention deficit hyperactivity disorder. However, the relationship between cannabis use and anxiety is equivocal. Mental health issues were more prevalent with increased frequency, duration, intensity, and type of use. Female, minority, LGBTQI, African American, Aboriginal, and Torres Strait Islander youth and the age of onset of cannabis use were significant factors for the development of mental health problems. The increasing prevalence of cannabis use among high school and college students suggests the need for intervention by teachers, parents, and community health professionals to make them aware of its potential negative mental health outcomes. Moreover, policy-level interventions by the government are required to discourage young people from using cannabis.

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Longitudinal associations of cannabis, depression, and anxiety in heterosexual and LGB adolescents.

Cited by 13 publications

References 72 publications

Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences

Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences

Cannabis use and mood disorders: a systematic review

Cannabis Use and Its Impact on Mental Health in Youth in Australia and the United States: A Scoping Review

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