Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study

Ho‐Pham, Lan T.; Nguyen, Huy G.; Nguyen-Pham, Son Q; Hoang, Duy K.; Tran, Thach; Nguyen, Tuan V.

doi:10.1007/s00198-023-06757-z

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…This is supported by the Study of Women's Health Across the Nation (SWAN) study which examined changes in BMD of the total lumbar and femoral neck in a community-based cohort with 292 premenopausal women and 141 in early postmenopausal women [21]. BMD remains stable in pre and early perimenopause [22], [23]. However, during late perimenopause and early postmenopausal period, there is a significant acceleration of bone loss with annual rates ranging from 1.0-2.3%.…”

Section: Resultsmentioning

confidence: 99%

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus

Nugroho,

Kurniawan,

Purnami

2024

IJPHS

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Diabetes mellitus negatively affects bone tissue and unfavourably impacts bone mineral density (BMD), therfore increasing the probability of fractures through pathological mechanisms. This study aimed to explore the factors associated with BMD and osteoporosis risk in individuals with a diagnosis of type 2 diabetes mellitus (T2DM). An investigation was undertaken involving 49 patients diagnosed with T2DM who fulfilled the specified criteria. These individuals underwent BMD assessment as part of a cross-sectional study. The analysis encompassed both univariate and bivariate approaches, utilizing the Chi-square test (X2) and binary logistic regression methods. A total of 30 participants (61%) have decreased BMD. Among the participants aged 60 years and above, 83.4% exhibited a decreased BMD status (osteopenia and osteoporosis), in contrast to the under 60 years age group, in which 40% displayed decreased BMD status. Older age (>60 years) is a risk factor for decreasing bone density onset of diabetes mellitus (DM) diagnosis, duration of DM, glycemic control, body mass index (BMI), use of thiazolidinediones (TZD) drugs, kidney function, were not associated with lower BMD in T2DM patients.

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Section: Resultsmentioning

confidence: 99%

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus

Nugroho,

Kurniawan,

Purnami

2024

IJPHS

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“…After menopause, estrogen de ciency does not immediately cause osteoporosis. Bone loss is usually gradual and progressive, and it goes through two stages: a rapid loss in the rst 5 years before menopause and a more gradual loss in the 10 years after menopause [28][29][30] . Estrogen plays a critical role in maintaining bone health by promoting bone formation and inhibiting bone resorption.…”

Section: Discussionmentioning

confidence: 99%

Study on the trend of changes in the gut microbiota of rats with ovariectomy-induced postmenopausal osteoporosis and the effect of estrogen intervention

lei,

Cheng,

Xia

et al. 2023

Preprint

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Postmenopausal osteoporosis (PMOP) is a common primary osteoporosis. With the aging of the population, it is becoming a major disease that endangers health and quality of life. The purpose of this study was to explore the effect of gut microbiota on PMOP by observing the changes in the levels of estradiol, bone density, and gut microbiota diversity in rats after 3 months of OVX surgery. We randomly divided 60 female SD rats into four groups: baseline group (6 rats), sham-operated group (18 rats), model group (18 rats), and estrogen-treated group (18 rats). The ovariectomy model of postmenopausal osteoporosis was established by performing bilateral ovariectomy. After surgery, 6 rats from each group were randomly sacrificed every 30 days and assessed. After 90 days, all rats were sacrificed and their body weight, bone mineral density (BMD), tissue mineral density (TMD), trabecular bone parameters, femoral bone morphology, hormone levels, and gut microbiota diversity were assessed. We found that OVX led to a decrease in BMD, TMD, and serum estradiol levels in rats, and Increases TNF-α levels. The bone micro-architecture and tissue morphology were also changed, with trabecular fractures, thinning, and decreased numbers. The gut microbiota diversity also changed. Estrogen treatment could improve these changes. OVX leads to a sustained decrease in estrogen levels in rats, which results in progressive bone loss. This is associated with an imbalance in the gut microbiota.

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Effects of Isoflavone Interventions on Bone Metabolism in Perimenopausal and Postmenopausal Women: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

Zhuge,

Chen,

Pan

2024

Endocrine Practice

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Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study

Cited by 6 publications

References 34 publications

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus

Study on the trend of changes in the gut microbiota of rats with ovariectomy-induced postmenopausal osteoporosis and the effect of estrogen intervention

Effects of Isoflavone Interventions on Bone Metabolism in Perimenopausal and Postmenopausal Women: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

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