Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football

Parivash, Sherveen N.; Goubran, Maged; Mills, Brian D.; Rezaii, Paymon; Thaler, Christian J.; Wolman, Dylan N.; Bian, Wei; Mitchell, Lex A.; Boldt, Brian M.; Douglas, David; Wilson, Eugene W.; Choi, Jinsoo; Xie, Lin; Yushkevich, Paul A.; DiGiacomo, Phil; Wongsripuemtet, Jitsupa; Parekh, Mansi; Fiehler, Jens; M., Huy; Lopez, Jaime; Rosenberg, Jarrett; Camarillo, David B.; Grant, Gerald A.; Wintermark, Max; Zeineh, Michael

doi:10.1089/neu.2018.6357

Cited by 21 publications

(16 citation statements)

References 65 publications

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“…Although we did not find significant differences in hippocampal size associated with more years of contact football exposure, the trend we observed of a median two point lower SCAT score accompanying a smaller visually-assessed right hippocampal size could possibly suggest a functional consequence of reduced right hippocampal volume. This parallels longitudinal quantitative hippocampal data showing progressive right hippocampal volume decreases in football compared to volleyball athletes from this same dataset ( 50 ). Furthermore, the presence of dilated perivascular spaces and their correlation with TBI has been shown by Inglese et al in 2005 and 2006 and also by Orrison et al in 2009, possibly indirectly reflective of brain volume loss ( 18 , 19 , 51 ).…”

Section: Discussionsupporting

confidence: 85%

“…Analysis of fractional anisotropy holes has generally been performed quantitatively ( 30 ), and our exploratory attempt at qualitative analysis did not prove fruitful. Detailed analysis of quantitative structural, diffusion, ASL and other metrics is beyond the scope of this study, but is the subject of our other published ( 13 , 50 ) and future manuscripts.…”

Section: Discussionmentioning

confidence: 99%

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Neuroradiologic Evaluation of MRI in High-Contact Sports

et al. 2021

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Background and Purpose: Athletes participating in high-contact sports experience repeated head trauma. Anatomical findings, such as a cavum septum pellucidum, prominent CSF spaces, and hippocampal volume reductions, have been observed in cases of mild traumatic brain injury. The extent to which these neuroanatomical findings are associated with high-contact sports is unknown. The purpose of this study was to determine whether there are subtle neuroanatomic differences between athletes participating in high-contact sports compared to low-contact athletic controls.Materials and Methods: We performed longitudinal structural brain MRI scans in 63 football (high-contact) and 34 volleyball (low-contact control) male collegiate athletes with up to 4 years of follow-up, evaluating a total of 315 MRI scans. Board-certified neuroradiologists performed semi-quantitative visual analysis of neuroanatomic findings, including: cavum septum pellucidum type and size, extent of perivascular spaces, prominence of CSF spaces, white matter hyperintensities, arterial spin labeling perfusion asymmetries, fractional anisotropy holes, and hippocampal size.Results: At baseline, cavum septum pellucidum length was greater in football compared to volleyball controls (p = 0.02). All other comparisons were statistically equivalent after multiple comparison correction. Within football at baseline, the following trends that did not survive multiple comparison correction were observed: more years of prior football exposure exhibited a trend toward more perivascular spaces (p = 0.03 uncorrected), and lower baseline Standardized Concussion Assessment Tool scores toward more perivascular spaces (p = 0.02 uncorrected) and a smaller right hippocampal size (p = 0.02 uncorrected).Conclusion: Head impacts in high-contact sport (football) athletes may be associated with increased cavum septum pellucidum length compared to low-contact sport (volleyball) athletic controls. Other investigated neuroradiology metrics were generally equivalent between sports.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Neuroradiologic Evaluation of MRI in High-Contact Sports

et al. 2021

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“…The key advantage of PMC in this setting is that we can achieve high SNR using averaging of scans with clinically tractable scan durations without the need for image registration, which can be difficult for slabs with limited coverage and can introduce blurring. Our rater analysis demonstrates that PMC with this system provides significantly improved overall image quality (ie, reduced motion artifact) and allows for better visualization of clinically important structures: the gray–white junction (focal cortical dysplasias), the deep gray nuclei (movement disorders), and the hippocampus (neurodegenerative diseases, epilepsy, and mild traumatic brain injury). The effect of motion correction is seen in healthy, compliant subjects with minimal motion, but a larger improvement is seen in the context of larger magnitude motion.…”

Section: Discussionmentioning

confidence: 94%

A within‐coil optical prospective motion‐correction system for brain imaging at 7T

DiGiacomo

Maclaren

Aksoy

et al. 2020

Magnetic Resonance in Med

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Purpose: Motion artifact limits the clinical translation of high-field MR. We present an optical prospective motion correction system for 7 Tesla MRI using a custombuilt, within-coil camera to track an optical marker mounted on a subject. Methods: The camera was constructed to fit between the transmit-receive coils with direct line of sight to a forehead-mounted marker, improving upon prior mouthpiece work at 7 Tesla MRI. We validated the system by acquiring a 3D-IR-FSPGR on a phantom with deliberate motion applied. The same 3D-IR-FSPGR and a 2D gradient echo were then acquired on 7 volunteers, with/without deliberate motion and with/ without motion correction. Three neuroradiologists blindly assessed image quality.In 1 subject, an ultrahigh-resolution 2D gradient echo with 4 averages was acquired with motion correction. Four single-average acquisitions were then acquired serially, with the subject allowed to move between acquisitions. A fifth single-average 2D gradient echo was acquired following subject removal and reentry. Results: In both the phantom and human subjects, deliberate and involuntary motion were well corrected. Despite marked levels of motion, high-quality images were produced without spurious artifacts. The quantitative ratings confirmed significant improvements in image quality in the absence and presence of deliberate motion across both acquisitions (P < .001). The system enabled ultrahigh-resolution visualization of the hippocampus during a long scan and robust alignment of serially acquired scans with interspersed movement. Conclusion: We demonstrate the use of a within-coil camera to perform optical prospective motion correction and ultrahigh-resolution imaging at 7 Tesla MRI. The 1662 | DIGIACOMO et Al.

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“…Hippocampal subfields were segmented based on coronal oblique T2-weighted images using Automated Segmentation of Hippocampal Subfields (ASHS) 37 and a customized atlas 38 . Briefly, multi-atlas segmentation and label fusion with machine-learning-based error correction are combined to give consistent and accurate MTL substructure segmentations.…”

Section: Methodsmentioning

confidence: 99%

Simultaneous FDG-PET/MRI detects hippocampal subfield metabolic differences in AD/MCI

Carlson

DiGiacomo

Fan

et al. 2020

Sci Rep

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The medial temporal lobe is one of the most well-studied brain regions affected by Alzheimer's disease (AD). Although the spread of neurofibrillary pathology in the hippocampus throughout the progression of AD has been thoroughly characterized and staged using histology and other imaging techniques, it has not been precisely quantified in vivo at the subfield level using simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI). Here, we investigate alterations in metabolism and volume using [ 18 F]fluoro-deoxyglucose (FDG) and simultaneous time-offlight (TOF) PET/MRI with hippocampal subfield analysis of AD, mild cognitive impairment (MCI), and healthy subjects. We found significant structural and metabolic changes within the hippocampus that can be sensitively assessed at the subfield level in a small cohort. While no significant differences were found between groups for whole hippocampal SUVr values (p = 0.166), we found a clear delineation in SUVr between groups in the dentate gyrus (p = 0.009). Subfield analysis may be more sensitive for detecting pathological changes using PET-MRI in AD compared to global hippocampal assessment. The medial temporal lobe (MTL), which includes the hippocampus and adjacent entorhinal and perirhinal cortices, is critical to memory formation and retrieval and well known to be involved in most forms of Alzheimer's disease (AD) 1. Neurodegeneration within the MTL thus leads to memory impairments in both AD and amnestic mild cognitive impairment (MCI) 2. This neurodegeneration results in atrophy that can be measured using structural MRI 3 and a reduction in metabolism of [ 18 F]fluoro-deoxyglucose (FDG) in PET imaging 4. The hippocampus is divided into subfields distinct in cytoarchitecture, connectivity, and function in both health and disease 5-9. From external to internal, relevant MTL subregions include perirhinal cortex (PRC), entorhinal cortex (ERC), subiculum (SUB), cornu ammonis fields 1-4 (CA1-4), and dentate gyrus (DG) (Fig. 1). ERC connects the neocortex to the hippocampus by primarily projecting to DG, which in turn projects to CA3, then to CA1 and to SUB, and back to ERC 10. AD neurofibrillary pathology spreads through the hippocampus as disease progresses. In the earliest stages of AD, neurofibrillary pathology is limited to the transentorhinal (part of PRC) and entorhinal cortices 11. As AD progresses, hippocampal involvement begins with neuron loss and tau tangles in CA1/2, progresses to CA3/4 and then to SUB and DG 12,13. AD symptoms are strongly correlated with the extent of hippocampal neurofibrillary involvement 14,15. Thus, image-based subfield measurements could be non-invasive biomarkers for diagnosis and staging of AD. Several MRI studies have shown that hippocampal subfield morphological measurements detect sensitive differences between AD, MCI, and healthy subjects. Some studies have found that CA1 and DG volume is reduced in AD subjects compared to MCI subjects 14,16 and may be a biomarker of presymptomatic AD 17-23. Development...

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Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football

Cited by 21 publications

References 65 publications

Neuroradiologic Evaluation of MRI in High-Contact Sports

Neuroradiologic Evaluation of MRI in High-Contact Sports

A within‐coil optical prospective motion‐correction system for brain imaging at 7T

Simultaneous FDG-PET/MRI detects hippocampal subfield metabolic differences in AD/MCI

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