Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy

Highman, Timothy J.; Friedman, Jacob E.; Huston, Larraine; Wong, William W.; Catalano, Patrick M.

doi:10.1016/s0002-9378(98)70540-x

Cited by 249 publications

(184 citation statements)

References 22 publications

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“…Moreover, serum leptinemia correlates with maternal body weight [118]. However, this elevation does not appear to be mediated by increased body weight and adiposity, since circulating leptin concentrations increase dramatically well before the occurrence of increased body weight [116]. Current data demonstrate that placenta is capable of contributing significantly to the higher levels of leptin seen in maternal circulation during healthy pregnancy [61,114,119,120].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 80%

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Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

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Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

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Section: Role Of Leptin In Pregnancymentioning

confidence: 80%

“…It is well known that serum leptin levels are higher in pregnant as compared to non-pregnant women [115][116][117]. Moreover, serum leptinemia correlates with maternal body weight [118].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 99%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

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“…Although, different studies had documented that serum leptin elevated during pregnancy with maximum concentrations at 22 and 27 weeks of gestation parallel with the peak of maternal fat accumulation [19], however, others reported elevated leptin concentrations during the 3rd trimester of pregnancy which decreases to pre-pregnancy concentrations around parturition [20,21]. An upward trend in leptin levels has been reported through the three trimesters which seems to parallel the increase in percent fat mass through the same three trimesters [22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the human placenta expresses high amounts of leptin messenger RNA (mRNA) and protein, while leptin receptors are abundant in the placenta, as well as the chorion and amnion [20]. There is evidence to suggest that placenta, rather than maternal adipose tissue makes a substantial contribution to the increase of maternal leptin concentrations [21]. The human placental leptin gene has a specific promoter region suggesting that placental leptin is differentially regulated as compared to leptin originating from adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Maternal Leptin, Adiponectin, Resistin, Visfatin and Tumor Necrosis Factor-Alpha in Normal and Gestational Diabetes

Noureldeen

Qusti²,

Al‐Seeni³

et al. 2013

Ind J Clin Biochem

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Gestational diabetes mellitus (GDM) is a common medical complication associated with pregnancy. The present study evaluates the changes in maternal adipocytokines (leptin, adiponectin, resistin, visfatin and tumor necrosis factor-alpha; TNF-a) in pregnancy complicated with GDM compared to normal pregnancy at 2nd and 3rd trimesters. The study included total number of 142 pregnant women classified into 4 groups: normal pregnancy (n = 33) and pregnancy with GDM (n = 24) both at 2nd trimester and normal pregnancy (n = 38) and GDM (n = 47) at 3rd trimester. Both GDM groups were significantly presented with elevated body mass index, fasting blood sugar and abnormal oral glucose tolerance test compared to their matched control. Results indicated reduction in maternal serum leptin and adiponectin in GDM compared to normal pregnancy at 3rd trimester. Elevated resistin and TNF-a were evident among pregnancy complicated with GDM at both tested trimesters. On the other hand, significant elevation in maternal visfatin was noted between GDM and matched control at 2nd trimester only. Significant increase in maternal leptin and visfatin and resistin was noted by advances in gestational period in healthy pregnancy. On the other hand, reduced adiponectin and elevated visfatin mean values were noticed in GDM at 3rd compared to 2nd trimester. It could be concluded that increased insulin resistance accompanies GDM is associated with suppressed leptin and adiponectin and increased resistin and TNF-a which might suggest their involvement in the development of GDM.

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“…An explanation for the lack of an association between leptin concentration and the total amount of phospholipidassociated fatty acids during late pregnancy could be that the women became leptin resistant. Many investigators proposed such a leptin resistant state during pregnancy (Chehab, 1997;Hardie et al, 1997;Highman et al, 1998;Mounzih et al, 1998;Sattar et al, 1998;Schrubing et al, 1997). They believe that this putative insensitivity to leptin could be of physiologic importance.…”

Section: Discussionmentioning

confidence: 99%

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

Rump

Otto

Hornstra³

2001

Eur J Clin Nutr

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Background: The n-3 fatty acid status changes during pregnancy and lactation. Plasma leptin concentrations and gene expression have been related to n-3 fatty acids. Objective: To investigate the relation between plasma leptin concentration and the docosahexaenoic acid (22:6n-3) content of plasma phospholipids during early pregnancy and the postpartum period. Design: Leptin (radioimmunoassay) and the phospholipid fatty acid pro®le (capillary gas-liquid chromatography) were measured in plasma of women during two independent longitudinal observational studies. Dietary intake of n-3 fatty acids was also determined. Results: Within the ®rst 10 weeks after the last menstrual period, an almost parallel increase in leptin concentration and the 22:6n-3 content (mgal and % wtawt) of plasma phospholipids was seen (study 1, n 21). During the postpartum period (study 2, n 57), leptin levels decreased quickly, preceding the changes in 22:6n-3 concentrations. During both studies, leptin concentrations did not consistently relate to dietary intake of n-3 fatty acids or to 22:6n-3 concentrations in plasma phospholipids. Before and during early pregnancy (study 1), signi®cant positive associations between leptin levels and the total amount of phospholipid-associated fatty acids were found. No such association was seen during late pregnancy or the postpartum period (study 2). The postpartum decrease in leptin levels did not differ between lactating and non-lactating women. Conclusions: Not the 22:6n-3 content, but the total amount of phospholipid-associated fatty acids was related to plasma leptin concentration, before and during early pregnancy but not during late pregnancy and the postpartum period. Sponsorship: Dutch Organization for Scienti®c Research (NWO, grant no. 904 62 186).

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Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy

Cited by 249 publications

References 22 publications

Role of leptin in female reproduction

Role of leptin in female reproduction

Maternal Leptin, Adiponectin, Resistin, Visfatin and Tumor Necrosis Factor-Alpha in Normal and Gestational Diabetes

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

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