Longitudinal changes in persistent organic pollutants (POPs) from 2001 to 2009 in a sample of elderly Swedish men and women

Stubleski, Jordan; Lind, Lars; Salihović, Samira; Lind, P. Monica; Kärrman, Anna

doi:10.1016/j.envres.2018.04.009

Cited by 16 publications

(23 citation statements)

References 55 publications

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“…The left y-axis illustrates the ordering of lipoprotein diameter in decreasing size, where the width of the right triangle corresponds to the relative diameter of the lipoprotein subclass high density lipoproteins. Within the PIVUS cohort, higher triglycerides have been associated with 15 cardiovascular-related protein biomarkers, suggesting a greater CVD risk with elevated triglyceride levels [40]. Other European cohorts have confirmed the association between high triglycerides and an increased risk of CVD [39,41,42].…”

Section: Discussionmentioning

confidence: 91%

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

et al. 2020

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Background Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), physically associates with lipids and accumulates in adipose tissue. Little is known about which lipoproteins associate with p,p’-DDE. An association between p,p’-DDE exposure and altered levels of circulating lipids was assessed in a large human cohort using a detailed analysis of lipoprotein content. Methods Plasma samples were collected from the subset of 75-year old Swedes in the Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) cohort who were not prescribed lipid lowering medication (n = 571). p,p’-DDE concentrations in plasma were measured using high-throughput solid phase extraction and gas chromatography-high resolution mass spectrometry. Analysis of plasma lipoprotein content was performed with nuclear magnetic resonance spectroscopy. Results Detectable levels of p,p’-DDE were found in the plasma samples of all subjects. Elevated p,p’-DDE levels were associated with increased concentrations of lipoproteins of all diameters, with the exception of high density lipoprotein (HDL) of diameters between 14.3 nm–10.9 nm. Of the lipoprotein constituents, triglycerides were most uniformly associated with elevated p,p’-DDE across lipoproteins. p,p’-DDE was furthermore associated with apolipoprotein B, but not apolipoprotein A1. Conclusions The positive associations observed between each lipoprotein class and elevated p,p’-DDE support previous data suggesting that p,p’-DDE interacts with lipoproteins within plasma. It is speculated that both physio-chemical and biological mechanisms may explain why p,p’-DDE does not uniformly associate with lipids across lipoproteins.

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Section: Discussionmentioning

confidence: 91%

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

et al. 2020

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“…Most of the major lipid-soluble POPs are banned from production and therefore the levels in humans and the environment are declining. 20 However, dietary intake from fat fish and meat is still a problem, and especially intake of fat fish from contaminated areas should be kept to a minimum. Also, PFASs are derived from fish and meat, but in this case many PFASs are still produced.…”

Section: Discussionmentioning

confidence: 99%

“… 19 Usually the sum of triglycerides and cholesterol is used as a proxy for measurements of total lipids. However, given the fact that POPs could change lipids levels, and that the changes in POP levels over 5 years were related to the changes in total lipid levels, 20 it is not clear that lipid-soluble POPs should be normalized for lipids. This is especially important in the case of atherosclerotic disease, for which an increase in LDL cholesterol could well be within the causal pathway between POP exposure and the disease.…”

Section: Lipid-soluble Pops and Circulating Lipoproteinsmentioning

confidence: 99%

Are Persistent Organic Pollutants Linked to Lipid Abnormalities, Atherosclerosis and Cardiovascular Disease? A Review

Lind

2020

J Lipid Atheroscler

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The term persistent organic pollutants (POPs) denotes chemicals with known or suspected adverse health effects in animals or humans and with chemical properties that make them accumulate in the environment, including animals or humans. Lipid-soluble POPs, like dioxins, polychlorinated biphenyls (PCBs) and organochlorine pesticides are transported by lipoproteins and accumulate in adipose tissue. High levels of these compounds in the circulation have been associated with elevated cholesterol and triglycerides in crosssectional studies and with an increase in mainly low-density lipoprotein cholesterol in a longitudinal study. Also, non-lipid-soluble POPs, such as perfluoroalkyl substances (PFASs) compounds have been associated with increased total cholesterol levels. Carotid artery atherosclerosis has been related to elevated levels of mainly highly chlorinated PCBs and to highly fluorinated PFASs, but in this case only in women. Both cross-sectional and prospective studies have shown dioxins, PCBs, as well as PFASs to be linked to cardiovascular disease (CVD) and mortality. In conclusion, as highlighted in this review, several lines of evidence support the view that POPs of different chemical classes could be linked to lipid abnormalities, carotid atherosclerosis and overt CVD like myocardial infarction and stroke.

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“…The level of detection divided by 2 0.5 was used for measurements below the level of detection. Previous publications 29 , 30 have given the levels of detection for the POPs.…”

Section: Methodsmentioning

confidence: 99%

Association of Exposure to Persistent Organic Pollutants With Mortality Risk

et al. 2019

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Key Points Question Are elevated levels of persistent organic pollutants associated with an increased mortality risk? Findings In a population-based cohort study of 992 individuals aged 70 to 80 years, 18 persistent organic pollutants were measured in plasma at 2 occasions. Elevated levels of highly chlorinated polychlorinated biphenyls (PCBs) were associated with increased mortality risk, mainly from cardiovascular diseases, during 10 years of follow-up. Meaning These results indicate that public health actions should be undertaken to limit exposure to PCBs.

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Longitudinal changes in persistent organic pollutants (POPs) from 2001 to 2009 in a sample of elderly Swedish men and women

Cited by 16 publications

References 55 publications

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

Are Persistent Organic Pollutants Linked to Lipid Abnormalities, Atherosclerosis and Cardiovascular Disease? A Review

Association of Exposure to Persistent Organic Pollutants With Mortality Risk

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