Longitudinal changes in serum catecholamines, dopamine, serotonin, ACTH and cortisol in pregnant Spanish mares

Marcilla, María Asunción Menargues; Muñoz, A.; Satué, K.

doi:10.1016/j.rvsc.2017.01.020

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…Cortisol concentrations of all mares did not show any differences between time points. Similar serum cortisol values in pregnant mares have been previously described (Flisinska-Bojanowka et al 1992, Satué et al 2011, Marcilla et al 2017. In pregnancy, this hormone is involved in the regulation of fetal metabolism and growth (Marcilla et al 2017).…”

Section: Discussionsupporting

confidence: 84%

Glucose and insulin curve in pregnant mares and its relationship with clinical and biometric features of newborn foals

Mousquer

Pereira

Finger³

et al. 2019

Pesq. Vet. Bras.

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The aim of the present study was to describe the dynamics of glucose and insulin curves in pregnant mares, and to evaluate the curves according to body condition score, identifying the presence of insulin resistance and correlating these values with the weight, height and clinical changes of the neonates. For this, pregnant mares were evaluated and then grouped according to body condition score during the gestation length until lactation. GrM corresponds to mares with moderate body score (BCS 5-6); GrOv were mares with overweight body score (BCS 7) and GrOb were obese mares (BCS 8-9). A two-step oral sugar test (OST) was used to determine the data. Cortisol analysis was performed with 300-320 days of gestation, at foaling and after parturition. For evaluation of the neonate, a general clinical examination and, weight and height measurements were performed. The results showed hyperglycemia in response to OST with normal insulin values at foaling with a subsequent fall in both values at lactation disregarding group division. Baseline glucose was decreased in GrM compared to GrOv and GrOb with 70-100 days of gestation and with 130-160 days of gestation. With 270-300 days of gestation and post-partum GrOb had increased baseline glucose than GrM. After OST, glucose at foaling day in GrOb presented increased values than GrM. Baseline insulin values did not differ between groups. Post OST insulin levels were higher in GrOb than GrM and GrOv at parturition. No difference in cortisol between moments was identified. GrOb and GrOv maintained increased concentrations after foaling while GrM had a decrease. No correlation was found between maternal glucose and insulin values with foal weight and height, however, a lower ratio between neonatal weight and mare’s weight in GrOb and GrOv was identified in relation to the GrM. At foaling, mares presented glucose dysregulation, with obese and overweight mares presenting a greater response to OST.

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Section: Discussionsupporting

confidence: 84%

Glucose and insulin curve in pregnant mares and its relationship with clinical and biometric features of newborn foals

Mousquer

Pereira

Finger³

et al. 2019

Pesq. Vet. Bras.

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“…Until now, one of the few studies on 5‐HT in reproductive mares has been reported by Marcilla, Muñoz, and Satué (). This study revealed systemic concentrations of 5‐HT 1.29 times higher than that of the mares in the present study.…”

Section: Discussionmentioning

confidence: 99%

Intrafollicular and systemic serotonin, oestradiol and progesterone concentrations in cycling mares

Satué

Fazio

Ferlazzo

et al. 2019

Reprod Domestic Animals

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The hypothesis that a local serotonergic network might also exist in the follicle of mares remains poorly documented, with exception for humans and laboratory species. For this reason, the aim of the present study was to clarify this possibility, investigating intrafollicular serotonin concentrations of the cycling mare at ovulation time. Sixty ovaries collected from 30 clinically healthy mares of slaughterhouse meat production with clinically normal reproductive tracts after slaughtering were evaluated. Blood samples were taken prior to sacrifice. Follicles were classified in three categories in relation to size, as small (20–30 mm), medium (31–40 mm) and large (>41 mm), and the follicular fluid samples were extracted from each follicle. Intrafollicular and systemic serotonin (5‐HT), oestradiol‐17β (E2) and progesterone (P4) were determined by means of enzyme‐linked immunosorbent assay and RIA, respectively. Intrafollicular 5‐HT, E2 and P4 concentrations were higher than systemic ones (p < .05). 5‐HT concentrations increased in larger compared to medium follicles, without differences compared to small size follicles (p < .05). 5‐HT and E2 (r = .79) and 5‐HT and P4 (r = .79; p < .05) were positively correlated. 5‐HT and P4 concentrations in follicular fluid increased progressively with the increase in follicular size (p < .05). Follicle diameter and E2 (r = .85) and P4 (r = .68) were correlated (p < .05). Since serotonin interacts with steroids, its role on steroidogenesis during growth of the dominant follicle may be suggested.

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“…In mares of different breeds, as in Spanish Purebred mares, Quarter Horse, Standardbred, Thoroughbred and arabians [32,54,95,96] CORT levels increase during the first half of gestation. The gestational period is associated with a state of insulin resistance, due to the antiinsulin effects of CORT, GH, lactogen and placental GH [97,98].…”

Section: Sexual Excitation and Reproductive Statementioning

confidence: 99%

Action Mechanisms and Pathophysiological Characteristics of Cortisol in Horses

Ambrojo¹,

Corzano²,

Poggi³

2018

Corticosteroids

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Cortisol (CORT), also known as stress hormone, plays a vital role in physiological processes such as electrolyte and fluid balance, cardiovascular homeostasis, carbohydrate, protein and lipid metabolism, immune and inflammatory responses, and sexual development and reproduction. Cortisol levels are influenced by various physiological factors such as race, age, circadian rhythm, seasonality, exercise and pregnancy. Also, some stressful conditions including isolation or transport, among others, modify levels of this hormone in the body. Excesses or deficiencies of cortisol cause important clinical problems such as Cushing's and Addison's syndromes, which contribute substantially to morbidity in equine medicine. Thus, in this review, we will develop the mechanisms of synthesis and regulation, as well as the physiological factors involved and the most important diseases related to the alteration of cortisol secretion in horses and foals.

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Longitudinal changes in serum catecholamines, dopamine, serotonin, ACTH and cortisol in pregnant Spanish mares

Cited by 17 publications

References 28 publications

Glucose and insulin curve in pregnant mares and its relationship with clinical and biometric features of newborn foals

Glucose and insulin curve in pregnant mares and its relationship with clinical and biometric features of newborn foals

Intrafollicular and systemic serotonin, oestradiol and progesterone concentrations in cycling mares

Action Mechanisms and Pathophysiological Characteristics of Cortisol in Horses

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