Longitudinal changes in viral RNA concentration in patients with chronic hepatitis C and/or HIV infection in the absence of antiviral therapy

Barreiro, Pablo; Labarga, Pablo; Fernández-Montero, José Vicente; Poveda, Eva; Mendoza, Carmen de; Sanchez, Clara Marijuan; Vispo, Eugenia; Soriano, Vincent

doi:10.1016/j.jcv.2013.06.031

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…Individuals with HIV may continue to experience neurologic dysfunction due to the virus despite good virologic control and nominal laboratory values. In fact, recent studies have found that plasma based biomarkers can fluctuate over the course of disease, and lose correlational relationships with degree of impairment [78–80]. Therefore it is important to combine metrics such as rs-fc that are sensitive to differences not seen by other typical tests used in evaluating HIV+ patients (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity

Ortega¹,

Brier²,

Ances

2015

Aids

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Objective Determine whether HIV and cART affect resting state functional connectivity (rs-fc) between the striatum and cortical regions. Methods 49 HIV uninfected (HIV−) and 132 HIV infected (HIV+) (65% receiving combination anti-retroviral treatment [cART]) had laboratory studies (current and nadir CD4 T-cell counts, and plasma HIV viral load), neuropsychological performance (NP) testing, and neuroimaging. Rs-fc, which examines the coordination of neural activity in distant brain regions, was used to investigate cortico-striatal functional connections. The effect of cART was assessed comparing HIV+ individuals on cART (HIV+/cART+), and HIV+ individuals not currently receiving cART (HIV+/cART−). Relationships between laboratory tests, cognitive performance, and cART on subcortical-cortical rs-fc were assessed by an analysis of variance. Results HIV+ individuals had lower cortico-striatal functional connectivity than HIV− controls, specifically between the striatum and default mode network (DMN; p <0.001) and ventral attention network (VATT; p <0.001). HIV+/cART+ individuals had higher functional connectivity between the striatum and DMN (p=0.02) and VATT (p = 0.01) compared to HIV+/cART− subjects. Laboratory (current and nadir CD4 T-cell counts, plasma viral load) and NP were not correlated with cortico-striatal rs-fc. Conclusions HIV was associated with disrupted cortico-striatal networks, consistent with HIV’s known impact on subcortical areas. Interestingly, within certain networks HIV+/cART+ individuals had similar rs-fc compared to HIV− controls, suggesting possible improvements in HIV related neural dysfunction due to medications. Rs-fc may be a sensitive biomarker of neural insult and its recovery following cART. Additional studies may show rs-fc has utility in measuring acute inflammation caused by HIV.

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Section: Discussionmentioning

confidence: 99%

Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity

Ortega¹,

Brier²,

Ances

2015

Aids

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“…Barreiro et al [16] stated that subjects with HIV-HCV co-infection are more likely than HIV-negative subjects to experience variations in HCV RNA load greater than 0.5 log over a mean period of 43 months. The number of patients surveyed was greater than that in our study (644 versus 82), but the proportion of patients on ART was similar to ours (82% and 86.7%, respectively).…”

Section: Discussionmentioning

confidence: 99%

HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study

et al. 2014

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BackgroundHCV RNA viral load is an important predictor of sustained virological response and, recently, a significant correlation with liver fibrosis was described. We investigated on possible influence of clinical and viro-immunological variables on HCV viral load in HIV-HCV co-infected patients over a study time of three years (2009-2012).MethodsWe retrospectively enrolled 98 adult patients with a diagnosis of chronic HIV infection in 2009, a diagnosis of chronic HCV infection with a detectable plasma HCV RNA in 2009 and 2012, HCV therapy-naïve or with failed and stopped antiviral treatment before June 2008. The following variables were recorded: age, gender, HCV genotype, IL28B rs12979860 CC genotype, HCV treatment status, advanced liver fibrosis diagnosis, antiretroviral therapy, CD4+ cell count, HCV viral load, HIV RNA (plasma HIV-1 RNA levels were measured from blood samples every three months at least). The correlation was established using linear regression analysis, analysis of variance and Fisher’s exact test. Comparisons between groups were performed using Fisher’s exact test, the independent samples t-test and the t-test for paired data, as appropriate, for continuous variables. A mixed mode (ME) maximum likelihood linear regression model was constructed to evaluate the dependence of HCV viral load.ResultsHCV RNA levels did not change significantly from 2009 to 2012 (from 3924650 ± 5320177 IU/ml to 3085128 ± 3372347 IU/ml, p = 0.13); the CD4+ count increased significantly (from a mean of 576 to a mean of 654, p = 0.003). Using linear regression, a positive correlation was observed for HCV load and genotype 1 (p = 0.002), nonresponder status (p = 0.04) and with interleukin 28B CC allele (p = 0.05). Other studied covariates failed to reach a significant correlation.ConclusionsThe HCV RNA load, a known pretreatment predictor of response to antiviral therapy, was independent of the two main parameters of HIV disease, plasma HIV RNA and CD4 cell count, over an observation time of 3 years in patients with recovered or spontaneously maintained immunocompetence.

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“…The association between HCV genotype 1 and the IL28B C allele with higher HCV RNA values is described in HIV-HCV-coinfected patients [11,15]; these findings demonstrated that no unintended selection bias occurred. Barreiro et al [16] stated that subjects with HIV-HCV co-infection are more likely than HIV-negative subjects to experience variations in HCV RNA load greater than 0.5 log over a mean period of 43 months. The number of patients surveyed was greater than that in our study (644 versus 82), but the proportion of patients on ART was similar to ours (82% and 86.7%, respectively).…”

Section: Discussionmentioning

confidence: 99%

HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: A 3-years follow-up study

Basso

Franzetti

Scaggiante

et al. 2014

Digestive and Liver Disease

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Longitudinal changes in viral RNA concentration in patients with chronic hepatitis C and/or HIV infection in the absence of antiviral therapy

Cited by 11 publications

References 36 publications

Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity

Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity

HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study

HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: A 3-years follow-up study

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