Longitudinal cytogenetic study of metaphase and interphase cells in childhood monosomy 7 syndrome

Stanley, Wayne S.; Devine, Grace C.; Murphy, Bridget A.; Seibel, Nita; Dinndorf, Patricia A.

doi:10.1016/0165-4608(92)90256-8

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Cited by 8 publications

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Molecular cytogenetic analysis of monosomy 7 in pediatric patients with myelodysplastic syndrome

Harrison¹,

Massing

McKenna

et al. 1995

American J Hematol

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Monosomy 7 is a non-random cytogenetic abnormality that is frequently associated with myelodysplastic syndromes (MDS). Twenty-four bone marrow samples from five pediatric patients with MDS were analysed using both traditional and interphase cytogenetic analysis. The majority of the metaphases were monosomic for chromosome 7 while interphase cytogenetic analysis consistently detected a disomic cell population in nondividing cell populations. This suggests that the monosomy 7 cells have a distinct proliferative advantage compared to the disomic cell population. The results demonstrate that interphase cytogenetic analysis provides important cytogenetic information about non-dividing cell subpopulations, enhancing our understanding of the cell dynamics of normal and monosomy 7 cells in MDS.

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