Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart, Elisabeth M. van; Steur, Lindsay M. H.; Braam, Katja I.; Veening, Margreet A.; Huisman, J.; Takken, Tim; Bierings, Marc; Merks, Johannes H. M.; Heuvel‐Eibrink, Marry M. van den; Kaspers, Gertjan J. L.; Broeder, Eline van Dulmen‐den; Litsenburg, Raphaële R. L. van

doi:10.1002/pbc.27949

Cited by 71 publications

(62 citation statements)

References 37 publications

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“…In the recently-published paper on the randomized MUCKI trial (on 33 patients so far, which goes to show how challenging it is to design randomized studies), the authors found a positive effect of exercise on fatigue ( 42 ). We know that fatigue interferes with an individual's ability to engage in everyday life activities and social roles (including educational and work opportunities), and that it causes mood swings, impairs social relations, and lowers academic achievement ( 21 , 22 ). One of the strengths of our study lies in that we examined several dimensions of HRQoL and fatigue, and the correlations between physical health, psychological functioning and fatigue as a whole.…”

Section: Lessons Learned and Discussionmentioning

confidence: 99%

“…Positive associations have been reported between HRQoL and fitness levels in childhood cancer survivors ( 18 , 19 ). Cancer-related fatigue is a common and distressing condition that significantly lowers the HRQoL of patients with cancer ( 20 , 21 ), but higher levels of physical activity have been associated with lower levels of cancer-related fatigue ( 22 ). The literature on the prevalence of cancer-related fatigue in children and adolescents is contradictory ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

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Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer

et al. 2021

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Background: Cancer and its treatment can cause serious health issues that impair physical and mental well-being in children and adolescents. Exercise may be a valid strategy for managing some symptoms, including fatigue. In the light of our experience, we provide further justification for including exercise as part of routine childhood cancer care.Methods: Forty-four children and adolescents who had solid cancers not contraindicating their movement were invited to join an in-hospital 6-week supervised exercise program, and asked afterwards to complete validated quality of life and fatigue scales. The program consisted of personalized workout sessions of aerobic, resistance and flexibility exercises. The results obtained on the scales were compared between 21 patients who engaged in the exercise program (GYM group) and 23 who refused (No-GYM group), examining the different dimensions of health-related quality of life (physical, emotional, cognitive, social) and fatigue (general, sleep/rest, cognitive) in the two groups.Results: Being diagnosed with cancer initially prompted all but one of the respondents to drop-out of previous routine exercise or sports although their continuation had not been contraindicated. After 6 weeks of exercise, the GYM group's scores for quality of life and fatigue showed a statistically significant better perceived emotional functioning, and a trend toward a better social functioning than in the No-GYM group.Conclusion: We suggest that exercise improves the satisfaction of children and adolescents with cancer with their physical, mental and social functioning. We would emphasize the potential benefits of general practitioners discussing and recommending exercise for their young patients with cancer.

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Section: Lessons Learned and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer

et al. 2021

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“…Physical activity levels were shown to be associated with fatigue levels during a one-year follow-up in a mixed cohort of childhood cancer patients and survivors [ 69 ]. Muscle strength was suggested to be related to fatigue in patients with advanced cancer [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

Penson

Deuren

Bronkhorst³

et al. 2021

BMC Med Res Methodol

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Background A debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the methodology of the Dutch Childhood Cancer Survivor Late Effect Study on fatigue (DCCSS LATER fatigue study). The aim of the DCCSS LATER fatigue study is to examine the prevalence of and factors associated with CRF, proposing a model which discerns predisposing, triggering, maintaining and moderating factors. Triggering factors are related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms. Maintaining factors are daily life- and psychosocial factors which may perpetuate fatigue once triggered. Moderating factors might influence the way fatigue symptoms express in individuals. Predisposing factors already existed before the diagnosis, such as genetic factors, and are thought to increase the vulnerability to develop fatigue. Methodology of the participant inclusion, data collection and planned analyses of the DCCSS LATER fatigue study are presented. Results Data of 1955 CCS and 455 siblings was collected. Analysis of the data is planned and we aim to start reporting the first results in 2022. Conclusion The DCCSS LATER fatigue study will provide information on the epidemiology of CRF and investigate the role of a broad range of associated factors in CCS. Insight in associated factors for fatigue in survivors experiencing severe and persistent fatigue may help identify individuals at risk for developing CRF and may aid in the development of interventions.

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“…Many studies found that fatigue was the most common adverse effect in adults with CML receiving TKItherapy, and fatigue was also the main reason for the worse HRQoL in adult patients [21,[30][31][32][33][34] . In our study, the rst two most common adverse effects reported were gastrointestinal disorders and skeletal muscle pain.…”

Section: Discussionmentioning

confidence: 99%

Health-related Quality of Life in Children With Chronic Myeloid Leukemia in the Chronic Phase

Zheng

Dou

Zhang

et al. 2021

Preprint

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Purpose To explore the health-related quality of life (HRQoL) and associated variables in children with chronic myeloid leukemia in the chronic phase (CML-CP) receiving tyrosine kinase inhibitors (TKIs).Methods A cross-sectional questionnaire was given to children with CML and their parents, who were <18 years at diagnosis of CML and <19 years at study. The questionnaire consisted of three parts, including demographic information, clinical information, and the Chinese version of Pediatric Quality of Life InventoryTM (PedsQL™) Cancer Module 3.0 as HRQoL questionnaire.Results 289 questionnaires were collected, and data from 207 (71.6%) respondents were analyzed. Multivariate analysis showed that children with symptoms had worse pain (-10.7; P<0.001), nausea(-17.9; P<0.001), treatment anxiety(-6.7; P=0.008), worse appearance self-assessment (-7.5; P<0.001) and communication problems(-3.9; P=0.028), and worse HRQoL(-4.1; P=0.013). Children whose mothers had low educational qualifications complained worse pain(-8.3; P=0.005), worried more about the future (-11.6; P=0.002), had poor self-assessment (-5.1; P=0.045), and worse HRQoL (-6.5; P=0.002). Children at a younger age of study when studied had more procedural anxiety (3.3; P=0.008), more cognition problems (3.4; P=0.001), and worse HRQoL (1.4; P=0.040), while increasing age at diagnosis had worse appearance self-assessment (-2.1; P=0.015) and HRQoL (-1.4; P=0.039). Other variables significantly associated with worse HRQoL included female sex and rural household registration. Parents reported more gastrointestinal disorders and worry about the future and had less concern about appearance than reported children.Conclusions This study suggests that female gender, increasing age at diagnosis, younger age at study, lower mother’s education level, and TKI-related symptoms reported were significantly-associated with worse HRQoL. Parents and children have different priorities in the HRQoL.

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Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Cited by 71 publications

References 37 publications

Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer

Positive Impact of Organized Physical Exercise on Quality of Life and Fatigue in Children and Adolescents With Cancer

Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

Health-related Quality of Life in Children With Chronic Myeloid Leukemia in the Chronic Phase

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