Despite being highly similar to different-sex couples in relationship quality, same-sex couples are at heightened risk for break-up, highlighting the need for research to identify risk factors for instability in same-sex relationships. Using a national sample of 595 adults involved in cohabiting same-sex romantic relationships, we examined several individual, relationship, and contextual factors as predictors of relationship instability. Specifically, we estimated crosssectional associations between perceived instability (i.e., thinking about and taking steps towards relationship dissolution) and depressive symptoms, sexual identity distress, relationship satisfaction, quality of alternatives, commitment, destructive couple conflict, and social support for the relationship. We examined the unique role of each factor controlling for demographics and relationship satisfaction, and tested for gender differences in associations. Results indicated that beyond relationship satisfaction, destructive conflict and lower social support for the relationship were associated with instability in both males and females in samesex relationships. For females only, instability was also predicted by higher sexual identity distress, quality of alternatives, and lower commitment. These findings suggest that same-sex relationship models and interventions may require some specificity based on the gender of the partners. Whereas destructive couple conflict and low relationship satisfaction may represent common risk factors for relationship instability across all couples, female couple stability may also be influenced by other individual, relationship, and contextual risk factors that represent potential targets for relationship interventions designed specifically for female couples.