2011
DOI: 10.1002/jbmr.516
|View full text |Cite
|
Sign up to set email alerts
|

Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease

Abstract: Fibroblast growth factor 23 (FGF23) is a phosphaturic and vitamin D-regulatory hormone of putative bone origin that is elevated in patients with chronic kidney disease (CKD). The mechanisms responsible for elevations of FGF23 and its role in the pathogenesis of chronic kidney disease-mineral bone disorder (CKD-MBD) remain uncertain. We investigated the association between FGF23 serum levels and kidney disease progression, as well as the phenotypic features of CKD-MBD in a Col4a3 null mouse model of human autos… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

10
119
1
2

Year Published

2012
2012
2020
2020

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 96 publications
(132 citation statements)
references
References 28 publications
10
119
1
2
Order By: Relevance
“…Consistent findings have been reported in pediatric CKD cohorts using the same assay (35) and other adult nondialysisdependent CKD cohorts using the Kainos iFGF23 assay (36). This temporal sequence is also borne out in longitudinal studies in murine models of progressive CKD (37). FGF23 concentrations increase inexorably as renal function falls, where intact full-length hormone seems to be the predominant circulating species (20,38).…”
Section: Does Fgf23 Measurement Add Value For Patients With Ckd? Ckd supporting
confidence: 74%
“…Consistent findings have been reported in pediatric CKD cohorts using the same assay (35) and other adult nondialysisdependent CKD cohorts using the Kainos iFGF23 assay (36). This temporal sequence is also borne out in longitudinal studies in murine models of progressive CKD (37). FGF23 concentrations increase inexorably as renal function falls, where intact full-length hormone seems to be the predominant circulating species (20,38).…”
Section: Does Fgf23 Measurement Add Value For Patients With Ckd? Ckd supporting
confidence: 74%
“…19 Mice with an inducible conditional knockout of NPT2b also maintain serum phosphate concentrations, possibly the result of compensatory increases in paracellular intestinal phosphate absorption and renal expression of NPT2a and NPT2c. 4,20 If phosphate binders were to upregulate expression of intestinal NPT2b and enhance paracellular transport, the efficacy of binders could be limited, particularly after missed doses. Clinical trials of niacin and niacin derivatives, which are known to inhibit the expression of intestinal NPT2b and kidney NPT2a, have shown significant reductions in serum phosphorus in patients with mild to moderate CKD.…”
Section: Discussionmentioning
confidence: 99%
“…A normal or near-normal serum phosphorus concentration is maintained at the expense of elevated levels of the phosphaturic hormones parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). 3,4 Serum concentrations of phosphorus and hormones responsible for its regulation have been implicated as putative cardiovascular risk factors. [5][6][7][8][9] Three intestinal phosphate binders are approved for the treatment of hyperphosphatemia in patients with ESRD in the United States-calcium acetate (Phoslo; Fresenius), lanthanum carbonate (Fosrenol; Shire), and sevelamer carbonate (Renvela; Genzyme)-but none are approved for use in patients with CKD not on dialysis.…”
mentioning
confidence: 99%
“…(26,53,54) We have extended these studies by characterizing the natural progression of CKD-MBD in the jck mouse, a genetic model of PKD, (28) as a first step toward defining the mechanistic link between renal dysfunction, declining bone, and cardiovascular disease. Importantly, we confirm that changes in jck serums closely mirror those observed in clinical serum samples as reported by Craver and colleagues, (29) albeit with some differences (Fig.…”
Section: Discussionmentioning
confidence: 99%