Longitudinal evaluation of symmetric dimethylarginine and concordance of kidney biomarkers in cats and dogs

Mack, Rebekah; Hegarty, Evan; McCrann, Donald J.; Michael, Helen; Grauer, Gregory F.

doi:10.1016/j.tvjl.2021.105732

Cited by 13 publications

(12 citation statements)

References 33 publications

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“…The effect of domperidone at the different time points on sSDMA, sCr, and sSDMA/sCR in group T compared with group C is shown in Table 2 . The number of dogs grouped according to sSDMA (≤ 14, 15–19, ≥ 20 μg/dl) [ 14 ] at T1, T2, and T3 is shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…The number of dogs grouped according to sSDMA (≤ 14, 15–19, ≥ 20 μg/dl) [ 14 ] at T1, T2, and T3 is shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, sSDMA seems a promising prognostic and predictive factor as a biomarker of kidney disease. Dogs with sSDMA of 15–19 μg/dl have a 2.5–4-fold higher risk of reduced renal function within 6 months than dogs with sSDMA ≤ 14 μg/dl [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

et al. 2022

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Background Chronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to improve kidney function in leishmaniotic dogs affected by CKD. Serum symmetric dimethylarginine (sSDMA) has also been shown to be a useful biomarker for earlier detection of decreased kidney function when compared to serum creatinine (sCr). This study aimed to assess the efficacy of domperidone plus renal diet in slowing the progression of nephropathy in leishmaniotic dogs with CKD, evaluating sSDMA and sCr as markers of kidney function. Methods This study was a therapeutic, prospective, randomized, controlled, 11-month-long field trial. Dogs were recruited if classified as “exposed” to or “infected” with Leishmania infantum and affected by CKD at early stages. After enrolment (T0), dogs were randomized into groups T (treatment) and C (control). All dogs were fed a renal diet and then followed up at 90 (T1), 210 (T2), and 330 (T3) days after inclusion in the study. At T1 and T2, dogs in group T received an oral suspension of domperidone (1 ml/10 kg once a day for up to 28 days). Results Twenty-two dogs (i.e., n = 12 in group T and n = 10 in group C) completed the study. At T0, the entire population of enrolled dogs presented a mean sSDMA value of 16.5 ± 3.4 μg/dl. At T1 (i.e., after 3 months of renal diet), sSDMA was significantly decreased in both groups, with an sSDMA of 13.1 ± 4.4 μg/dl for the entire population involved. From T1 to T3, sSDMA gradually increased in group C, while remaining stable in group T, which continued to show a significantly lower value of sSDMA at T3 than at T0. Regarding sCr, at T0 and T1, the mean values of the entire population of dogs were 1.1 ± 0.3 and 1.0 ± 0.4 mg/dl, respectively, with no statistical differences between groups T and C. In group T, sCr decreased significantly from T0 to T1, while returning at T3 to values similar to T0. Conclusions In this study, domperidone plus renal diet reduced the progression of kidney disease in leishmaniotic dogs affected by CKD. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

“…The number of dogs grouped according to sSDMA (≤ 14, 15–19, ≥ 20 μg/dl) [ 14 ] at T1, T2, and T3 is shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

et al. 2022

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“…Furthermore, given the presumptive high sensitivity of SDMA in the context of detecting early renal dysfunction, 137,142 even in animals with normal muscle condition, a repeatable SDMA concentration of >18 μg/dL in the face of concurrent normal creatinine concentrations (IRIS CKD stage 1 based on creatinine) can be used to assign IRIS stage 2 CKD status 53 . This recommendation by IRIS was supported by a recent longitudinal study showing 24%–92% of cats with persistent SDMA elevations (with concurrent normal creatinine concentration) will develop concordantly increased creatinine concentrations over the next 2 years, with the probability of concordant results increasing as the baseline SDMA concentration increases, supporting the concern of persistent or progressive decline in renal function in animals with persistently elevated SDMA 147 . Furthermore, a recent study assessing the GFR, SDMA and creatinine concentration of non‐azotaemic dogs found a SDMA cut‐off of >18 μg/dL optimised both sensitivity and specificity of a decreased GFR 148 .…”

Section: Feline Hyperthyroidism and Kidney Functionmentioning

confidence: 92%

“…53 This recommendation by IRIS was supported by a recent longitudinal study showing 24%-92% of cats with persistent SDMA elevations (with concurrent normal creatinine concentration) will develop concordantly increased creatinine concentrations over the next 2 years, with the probability of concordant results increasing as the baseline SDMA concentration increases, supporting the concern of persistent or progressive decline in renal function in animals with persistently elevated SDMA. 147 Furthermore, a recent study assessing the GFR, SDMA and creatinine concentration of non-azotaemic dogs found a SDMA cut-off of >18 μg/dL optimised both sensitivity and specificity of a decreased GFR. 148 A parallel study in cats not yet available.…”

Section: Hypothyroidism After Radioiodine Treatmentmentioning

confidence: 99%

Hyperthyroid cats and their kidneys: a literature review

Lacorcia

Johnstone

2022

Aust Veterinary J

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Hyperthyroidism and chronic kidney disease (CKD) are common diseases of geriatric cats, and often occur concurrently. Thus, a thorough understanding of the influence of thyroid function on renal function is of significant value for all feline practitioners. Among other effects, hyperthyroidism causes protein catabolism and increases renal blood flow and glomerular filtration rate (GFR). These effects render traditional renal markers insensitive for the detection of CKD in cats with uncontrolled hyperthyroidism. Furthermore, the development of iatrogenic hypothyroidism with over treatment of hyperthyroidism can be detrimental to renal function and may negatively affect long-term survival. This review discusses important diagnostic considerations of feline hyperthyroidism, as well as key treatment modalities, with an emphasis on the use of radioiodine and the importance of post treatment monitoring of thyroid and renal parameters. In Australia, a common curative treatment for cats with benign hyperthyroidism (i.e. thyroid hyperplasia or adenoma) is a fixed dose of orally administered radioiodine, regardless of the serum total thyroxine concentration at the time of diagnosis. This review discusses the long term outcomes of this standard of care in comparison with current, relevant research literature from around the world. Finally, this review explores the use of symmetric dimethylarginine (SDMA) in assessing renal function before and after treatment in hyperthyroid cats. SDMA correlates well with GFR and creatinine in non-hyperthyroid cats, but our understanding of its performance in hyperthyroid cats remains in its infancy.

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Symmetrical Dimethylarginine: Evaluating Chronic Kidney Disease in the Era of Multiple Kidney Biomarkers

Michael

Szlosek

Clements

et al. 2022

Veterinary Clinics of North America: Small Animal Practice

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Longitudinal evaluation of symmetric dimethylarginine and concordance of kidney biomarkers in cats and dogs

Cited by 13 publications

References 33 publications

Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

Hyperthyroid cats and their kidneys: a literature review

Symmetrical Dimethylarginine: Evaluating Chronic Kidney Disease in the Era of Multiple Kidney Biomarkers

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