Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Gunstad, John; Lhotsky, April; Wendell, Carrington R.; Ferrucci, Luigi; Zonderman, Alan B.

doi:10.1159/000297742

Cited by 319 publications

(273 citation statements)

References 103 publications

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“…При любом способе количественной оценки ожирения (ИМТ, ОТ/ОБ, ОТ) оно одинаково ассо-циируется с нарушениями КФ [8]. Однако следует учитывать, что в настоящее время выделяют под-кожный и висцеральный жир, последний, в свою очередь, обладает мощной нейрогуморальной активностью, оказывающей сильное влияние на продукцию адипокинов и ИР [4,9], в связи с чем именно ВО ассоциируется со структурными из-менения в ГМ [10] и когнитивными нарушениями (КН) [5].…”

Section: Discussionunclassified

Neurocognitive Disorders Among Patients With Visceral Obesity in Perioperative Period of Coronary Bypass Surgery

Чугунова¹,

Чумакова²,

Веселовская³

2016

Kompleks. probl. serdečno-sosud. zabol.

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1 Государственное бюджетное образовательное учреждение высшего профессионального образования «Алтайский государственный медицинский университет» Минздрава РФ. Барнаул, Россия 2 Краевое государственное бюджетное учреждение здравоохранения «Алтайский краевой кардиологический диспансер». Барнаул, РоссияВисцеральное ожирение (ВО) является предиктором осложнений после коронарного шунтирования (КШ) и фактором риска когнитивных и психологических нарушений.Цель. Изучение особенности нейрокогнитивных нарушений и их взаимосвязей у пациентов с ВО в периоперационном периоде КШ.Материалы и методы. В исследование включено 90 пациентов с индексом массы тела от 25 до 35 кг/м 2 и определенными показаниями к КШ. Наличие ВО оценивалось по показателю «окружность талии/окружность бедер» (От/ОБ). группу 1 составили пациенты с ВО при От/ОБ >0,9 для мужчин и От/ОБ >0,85 для женщин, группу 2 -пациенты без ВО при От/ОБ ≤0,9 для мужчин и От/ОБ ≤0,85 для женщин. для оценки когнитивных функций использована программа Status Pf (Кемерово, Россия), тревога оце-нивалась по шкале реактивной тревожности (Рт) и личностной тревожности (лт) Спилбергера -Ханина.Результаты. В группе 1 отмечались статистически значимо более низкие показатели внимания и нейродинамики и более высокие уровни депрессии и тревоги в периоперационном периоде КШ. В группе 1 при более высоких уровнях лт отмечалось снижение памяти и нейродинамики в периоперацонном периоде КШ; а в группе 2 повышение уровня лт не всегда приводило к нарушению внимания и нейродинамики. Более того, в группе 2 при высоких уровнях лт через 6 месяцев после КШ наблюдались более высокие показатели внимания и нейродинамики. Высокий уровень Рт в обеих группах негативно отражался на показателях нейродинамических процессов и внимания в периоперационном периоде КШ.Выводы. Пациенты с ВО имеют высокий риск развития психокогнитивных нарушений в периоперационном периоде КШ. Ключевые слова: висцеральное ожирение, коронарное шунтирование, тревога, когнитивные нарушения. Visceral obesity (Vo) is a predictor of complications after coronary artery bypass grafting (CABG), and a risk factor for cognitive and psychological disorders. NEUROCOGNITIVE DISORDERS AMONG PATIENTS WITH VISCERAL OBESITY IN PERIOPERATIVE PERIOD OF CORONARY BYPASS SURGERYPurpose. of our study was to investigate features of neurocognitive disorders and their interactions in patients with Vo in a perioperative period of CABG.Materials and methods. 90 patients with a body mass index from 25 to 35 kg/m 2 were included in the study, they had indications for CABG. Vo was assessed in terms of «waist circumference/hip circumference» (WC/HC). Group 1 included patients with Vo (WC/HC >0.9 for men and WC/HC >0.85 for women), Group 2 -patients without Vo (WC/HC ≤0,9 for men and WC/HC ≤0,85 for women). Cognitive functions were evaluated with the use of the automated complex software Status Pf (Kemerovo, Russia). the Spielberger State-trait Anxiety Inventory (StAI-t, StAI-S) was used for an estimation of anxiety.Results. Group 1 showed statistically lower rates o...

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Section: Discussionunclassified

Neurocognitive Disorders Among Patients With Visceral Obesity in Perioperative Period of Coronary Bypass Surgery

Чугунова¹,

Чумакова²,

Веселовская³

2016

Kompleks. probl. serdečno-sosud. zabol.

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“…Previous studies reported an association between obesity and insulin resistance [38,42]. The relation between insulin resistance and cognitive decline, especially memory impairment was mentioned in some studies [17]. Worldwide, approximately 347 million people are affected by diabetes, mainly type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, data regarding the role of VD are inconclusive [16]. The link between cognitive impairment and obesity has been reported in previous studies mediated through insulin resistance [17,18]. The VD deficiency may be an additional mode of action that contributes to the cognitive impairment reported in the obese individuals.…”

Section: Introductionmentioning

confidence: 96%

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

2014

Maced J Med Sci

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SUBJECTS AND METHODS:This study included 2 groups, Group-1(cases) consists of 120 obese females and Group-2 (controls) consists of 30 non-obese females. The included females were subjected to full clinical examination, anthropometric measurements and Kendrick Battery for evaluation of cognitive functions (short term memory and attention). Evaluation of serum Vitamin D, Parathyroid hormone, C-peptide and fasting blood glucose were done. The obese group was put on a balanced low caloric diet (900-1000 K Calories/day) for 2 months, where reevaluation was performed. RESULTS:Comparing obese group with non-obese control group revealed significant lower mean level of serum vitamin D associated with significant lower cognitive functions test and higher fasting blood glucose. After 2 months of low caloric diet, a significant increase in the serum level of vitamin D, accompanied with improvement in cognitive functions and decrease in fasting blood glucose and improved insulin resistance was seen. A correlation is found between vitamin D serum level and cognitive functions.CONCLUSION: A lower vitamin D serum level could be a modifiable risk factor for obesity, insulin resistance and cognitive impairment in middle age females.

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“…(2005) yaptıkları çalışma sonucu yüksek BKİ'nin daha iyi bilişsel fonksiyon sağladığına dair bulgular elde etmiş ve yaşlılarda kilo kaybının Alzheimer'ın ön belirtilerinin görüldüğü süreçte fonksiyonel yetenekleri azaltacağı hipotezi öne sürülmüştür. Ancak bu daha düşük bir ihtimal gibi gözükmektedir (34,35).…”

Section: Obezite Ve Bilişsel Fonksiyonla İlgili Mekanizmalarunclassified

Relationship between cognitive functioning impairment and nutrition in obesity: Current Perspective

Macit¹,

Karadağ²

2014

MUSBED

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Obezitede bilişsel fonksiyon bozukluğu ve beslenme ilişkisi: Güncel bakış Obezite son yıllarda artan prevelansı ile ciddi halk sağlığı sorunlarından biridir. Sebep olduğu sağlık problemlerinin yanı sıra bilişsel fonksiyonla da yakından ilişkilidir. Azalmış bilişsel ve özellikle dil, motor kapasite, dikkat gibi yetenekleri kapsayan yönetimsel fonksiyon ile ilişkilendirilmektedir. Ayrıca beyin volümünde azalma, demans, Alzheimer, sosyopati, agresif kişilik özellikleri, anksiyete, major depresif bozukluk, depresyon gibi psikolojik bozukluklarla da etkileşimi bulunabilir. Obezite ve bilişsel fonksiyonu ilişkilendiren, obezite ile birlikte artmış vasküler hasar, kan basıncı, C-reaktif protein (CRP), kortizol, tümör nekroz faktörü, serum amiloid A seviyeleri, insülin, leptin ve metabolit seviyelerinde bozukluklar benzeri çeşitli mekanizmalar mevcuttur. Obezite insülin, leptin ve metabolit seviyelerinde bozukluklara neden olmaktadır. Bu bozukluklar beyinde atrofik değişikliklere neden olarak bilişsel performansı etkilemektedir. Son yıllarda üzerinde çalışılan FTO geni de obezite-bilişsel gelişim ilişkisini açıklamada değinilen konulardandır. Alzheimer, parkinson, şizofreni, bipolar bozukluk ve azalmış beyin volümünün neden olduğu düşük IQ, obezitenin en fazla ilişkilendirildiği hastalıklardandır. Bu ilişkinin altında yatan mekanizmaların açıklanması için daha fazla çalışmaya ihtiyaç vardır. Bu çalışmada literatür taraması ile obezite ve bilişsel gelişim ilişkisinin ortaya konması amaçlanmıştır. Anahtar sözcükler: Beyin, bilişsel fonksiyon, IQ, obezite ABS TRACT Relationship between cognitive functioning impairment and nutrition in obesity: Current PerspectiveObesity is one of the serious public health problems and its prevalence has been increasing in recent years. As well as causing health problems, obesity is associated with cognitive function impairment, especially with reduced language, motor capacity skills, and attention named as executive functions. Obesity is also related to decrease in brain volume, dementia, Alzheimer's disease, sociopathic, aggressive personality traits, anxiety, and major depressive disorder. There are several mechanisms; increased vascular damage, blood pressure, C-reactive protein (CRP), cortisol, tumor necrosis factor, serum amyloid A levels explaining the relationship between obesity and cognitive functioning. Obesity generates fluctuations in levels of insulin, leptin and metabolites. These fluctuations may affect cognitive capacity by causing atrophic changes in the brain. FTO gene is also being studied to explain the relationship between obesity and cognitive function. Alzheimer's disease, Parkinson's disease, schizophrenia, and bipolar disorder are disorders commonly associated with obesity. Besides these disorders, some studies reported associations between decreases in brain volume and IQ levels and obesity. To investigate the underlying mechanisms between these two matters, more longitudinal studies are needed. In this review, we aimed to study the relationship between obesity and...

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Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

Cited by 319 publications

References 103 publications

Neurocognitive Disorders Among Patients With Visceral Obesity in Perioperative Period of Coronary Bypass Surgery

Neurocognitive Disorders Among Patients With Visceral Obesity in Perioperative Period of Coronary Bypass Surgery

Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women

Relationship between cognitive functioning impairment and nutrition in obesity: Current Perspective

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