Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants

Gillespie, Nathan A.; Kendler, Kenneth S.; Prescott, Carol A.; Aggen, Steven H.; Gardner, C. O.; Jacobson, Kristen C.; Neale, Michael C.

doi:10.1017/s0033291707009920

Cited by 32 publications

(30 citation statements)

References 88 publications

(113 reference statements)

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“…The use of retrospective data for the measurement of alcohol use has been utilized in many other studies [e.g., Gillespie et al, 2007; Schuckit et al, 2006] and been validated [Longnecker et al, 1992], but, in so far as some of our data are retrospective, it is a limitation. This limitation is somewhat ameliorated by the use of collateral reports of husbands’ and wives’ drinking.…”

Section: Discussionmentioning

confidence: 99%

Effects of physical and verbal aggression, depression, and anxiety on drinking behavior of married partners: a prospective and retrospective longitudinal examination

Keiley

Keller

El‐Sheikh

2009

Aggressive Behavior

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In an ethnically diverse sample of 195 married couples, we conducted a latent factor growth analysis to investigate the longitudinal link (4 time points over 4½ years) between marital aggression (physical and verbal aggression self- and partner-reports) and individual internalizing symptoms (depression and anxiety) as they relate to trajectories of alcohol use among husbands and wives. Alcohol use was operationalized as a latent factor with self- and partner reports of problem drinking as measured by the Michigan Alcoholism Screening Test and the Alcohol Dependence Scale. Verbal aggression by husbands or wives, by itself, has no effect on their alcohol use over time. In conjunction with depression, however, verbally aggressive husbands do have elevated drinking levels. The effects of husbands’ and wives’ physical aggression on their own and their partners’ drinking behavior were also significant. This study is one of the first to examine the change over time in alcohol use for marital partners as related to marital aggression and internalizing symptoms. Our results shed light on areas of marital functioning (aggression, internalizing, alcohol use) that have not been investigated in conjunction with each other in a longitudinal design. Aggr.

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Section: Discussionmentioning

confidence: 99%

Effects of physical and verbal aggression, depression, and anxiety on drinking behavior of married partners: a prospective and retrospective longitudinal examination

Keiley

Keller

El‐Sheikh

2009

Aggressive Behavior

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“…1, 2 are purely descriptive and call for further analysis in order to elucidate the possible underlying processes of developmental change in the effects of genes and environment on the patterns of twin resemblance within and between ages. The broad qualitative findings summarized above may arise from either or both of two different conceptions of how development proceeds (see Gillespie et al 2007). …”

Section: Methodsmentioning

confidence: 99%

“…It is conceivable, for example, that genetic influences account for individual differences in levels and rates of change, while autore-gressive effects account for the remembering or forgetting of time-dependent non-genetic influences. Efforts to combine the feature of autoregressive (Eaves et al 1986) with those from standard latent growth models (McArdle 1994; McArdle and Anderson 1989; McArdle and Hamagami 1991; Nesselroade and Baltes 1974), which are mathematically and statistically equivalent to random coefficient, multilevel or hierarchical linear models (Bryk and Raudenbush 1987; McArdle 1988; McArdle and Hamagami 1992; McArdle et al 1991; Mehta and West 2000; Miyazaki and Raudenbush 2000), have been applied to cognition (Finkel et al 2007; McArdle 1986) and drug availability (Gillespie et al 2007). One recent report has fitted a dynamic model to depression (Hishinuma et al 2012) but not within a genetically informative framework.…”

Section: Introductionmentioning

confidence: 99%

Testing Models for the Contributions of Genes and Environment to Developmental Change in Adolescent Depression

Gillespie

Eaves²,

Maes³

et al. 2015

Behav Genet

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We tested two models to identify the genetic and environmental processes underlying longitudinal changes in depression among adolescents. The first assumes that observed changes in covariance structure result from the unfolding of inherent, random individual differences in the overall levels and rates of change in depression over time (random growth curves). The second assumes that observed changes are due to time-specific random effects (innovations) accumulating over time (autoregressive effects). We found little evidence of age-specific genetic effects or persistent genetic innovations. Instead, genetic effects are consistent with a gradual unfolding in the liability to depression and rates of change with increasing age. Likewise, the environment also creates significant individual differences in overall levels of depression and rates of change. However, there are also time-specific environmental experiences that persist with fidelity. The implications of these differing genetic and environmental mechanisms in the etiology of depression are considered.

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“…Summing results from these studies using meta-analytic techniques, they reported that for initiation of cannabis use, 48% of variance in liability in males and 40% of the variance in females could be attributed to additive genetic factors while the estimates for problematic cannabis use were 51% and 59%, respectively. Modest genetic influences on availability of cannabis have also been reported (Gillespie et al, 2007). …”

Section: Heritability Of Cannabis Use and Cannabis Use Disordersmentioning

confidence: 99%

An Australian Twin Study of Cannabis and Other Illicit Drug Use and Misuse, and Other Psychopathology

et al. 2012

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Cannabis is the most widely used illicit drug throughout the developed world and there is consistent evidence of heritable influences on multiple stages of cannabis involvement including initiation of use and abuse/dependence. In this paper, we describe the methodology and preliminary results of a large-scale interview study of 3,824 young adult twins (born 1972–1979) and their siblings. Cannabis use was common with 75.2% of males and 64.7% of females reporting some lifetime use of cannabis while 24.5% of males and 11.8% of females reported meeting criteria for DSM-IV cannabis abuse or dependence. Rates of other drug use disorders and common psychiatric conditions were highly correlated with extent of cannabis involvement and there was consistent evidence of heritable influences across a range of cannabis phenotypes including early (≤15 years) opportunity to use (h2 = 72%), early (≤16 years) onset use (h2 = 80%), using cannabis 11+ times lifetime (h2 = 76%), and DSM abuse/dependence (h2 = 72%). Early age of onset of cannabis use was strongly associated with increased rates of subsequent use of other illicit drugs and with illicit drug abuse/dependence; further analyses indicating that some component of this association may have been mediated by increasing exposure to and opportunity to use other illicit drugs.

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Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants

Abstract: Background-We fitted ordinal latent growth models to measures of drug availability to determine the trajectories of genetic and environmental effects over time.

Cited by 32 publications

References 88 publications

Effects of physical and verbal aggression, depression, and anxiety on drinking behavior of married partners: a prospective and retrospective longitudinal examination

Effects of physical and verbal aggression, depression, and anxiety on drinking behavior of married partners: a prospective and retrospective longitudinal examination

Testing Models for the Contributions of Genes and Environment to Developmental Change in Adolescent Depression

An Australian Twin Study of Cannabis and Other Illicit Drug Use and Misuse, and Other Psychopathology

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