Longitudinal MR imaging study in the prediction of ischemic susceptibility after cerebral hypoperfusion in rats: Influence of aging and hypertension

Role of CSE-Produced H2S on Cerebrovascular Relaxation via RhoA-ROCK Inhibition and Cerebral Ischemia-Reperfusion Injury in Mice

“…Furthermore, the bilateral CCA occlusion (2-VO) was used as a model of global cerebral ischemia, which was widely used in the previous studies , and associated with a disruption of learning and memory function . Cerebral I/R injury could produce large amounts of oxygen-free radicals in neurocytes and subsequently cause lipid peroxidation and cerebral damage.…”

Neuroprotective Mechanism of BNG-1 against Focal Cerebral Ischemia: A Neuroimaging and Neurotrophin Study

“…In the ADC, MIP of SWI, and CBF measurements, a template of four predetermined regions of interest at the bilateral parietal cortex and striatum was applied for the spatial transformation analysis based on T2-weighted MR images [23] according to our previous method [24] . The spatial transformation procedure was conducted using SPM5 software (Wellcome Department of Cognitive Neurology, London, UK) implemented in Matlab 7.0 (Mathworks Inc, Sherborn, MA, USA).…”

Animal Models of Focal Cerebral Ischaemia and Haemorrhagic Transformation: Considerations in Experimental Stroke Study Design

“…To ensure reproducibility it is important to optimise the procedure and occluder properties to ensure successful occlusion of the MCA and reduce the likelihood of inadequate occlusion or complications, such as subarachnoid haemorrhage. Several techniques have been used to give absolute or relative measurement of cerebral blood flow; including laser Doppler imaging/flowmetry [25,26], near infra-red spectroscopy [27], perfusion-weighted magnetic resonance [28,29] or speckle contrast imaging [30,31]. Measurement of cerebral blood flow can be used to confirm reduction in cerebral blood flow in the territory of the MCA [26], which can dramatically improve reproducibility [25].…”