2024
DOI: 10.1038/s41564-024-01635-8
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Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

Braden T. Tierney,
JangKeun Kim,
Eliah G. Overbey
et al.

Abstract: Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts during spaceflight has been difficult due to mission constraints that lead to limited sampling and profiling. Here we executed a six-month longitudinal study to quantify the high-resolution human microbiome response to three days in orbit for four individuals. Using paired metagenomics and metatranscriptomics alongside single-nuclei immune cell profiling… Show more

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Cited by 16 publications
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