MHD-induced energetic ion loss in neutral beam heated H-mode discharges in NSTX is discussed. A rich variety of energetic ion behavior resulting from magnetohydrodynamic (MHD) activity is observed in NSTX using a horizontally scanning neutral particle analyzer whose sightline views across the three co-injected neutral beams. Reconnection events, sawteeth and bounce fishbones are observed to cause prompt loss (or redistribution) of energetic ions (E ~ 10 -100 keV) on a time scale of ≤ 1 ms and, consequently, a precipitous drop in the neutron yield. On the other hand, onset of low-n MHD modes leads to a much slower decay of the energetic ions and neutron yield. MHD-induced ion loss during H-mode operation in NSTX exhibits yet another phenomenon. After H-mode onset, the NPA spectrum usually exhibits a significant loss of energetic ions mainly for E > E b /2 where E b is the beam injection energy, although this loss occasionally extends to lower energy. The magnitude of the energetic ion loss diminishes with increasing tangency radius of the NPA sightline, increasing toroidal field and increasing NB injection energy. Modeling suggests that MHD-induced ion loss is enhanced during H-mode operation due to an evolution of the q and beam deposition profiles that feeds both passing and trapped ions into the region of the plasma affected by the low-n MHD activity. Analysis of the particle interaction with a model magnetic perturbation supports the energy selectivity of the observed MHD-induced loss. Transport analysis using a fast ion diffusion model to emulate MHD-induced energetic ion loss shows significant modifications of the heating produced by the neutral beam which changes the inferred power balance, thermal External Distribution