Longitudinal relationships between mismatch negativity, cognitive performance, and real-world functioning in early psychosis

Higgins, Amy; Lewandowski, Kathryn Eve; Liukasemsarn, Saran; Hall, Mei‐Hua

doi:10.1016/j.schres.2021.01.009

Cited by 16 publications

(16 citation statements)

References 80 publications

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“…Thus, rather than being a specific diagnostic biomarker, attenuated MMN is likely a more dimensional and transdiagnostic marker of vulnerability to mental or neurological disorders. This notion fits well with observations that attenuated MMN amplitudes in adults with first episode psychosis or schizophrenia are associated with impaired level of adaptive and social functioning (Higgins et al, 2021; Light & Braff, 2005; Naatanen et al, 2011), consistent with the findings of the present study. Indeed, the complex interplay between genetic predispositions and atypical maturational trajectories of basic brain functions as biomarkers of vulnerability to later development of psychopathological symptoms and consequently reduced level in adaptive functioning has recently given rise to theories that aim to capture the dynamic course of autism from a translational psychiatric framework (Aggernæs, 2020).…”

Section: Discussionsupporting

confidence: 93%

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

et al. 2022

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Section: Discussionsupporting

confidence: 93%

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

et al. 2022

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“…Third, the MMN paradigm followed our established methods ( Higgins et al, 2021 ). Briefly, a passive auditory oddball (in response to duration deviants) paradigm was employed.…”

Section: Methodsmentioning

confidence: 99%

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Kozhemiako

Wang

Chen-guang

et al. 2022

eLife

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Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple NREM components, statistically predicted disease status in the replication cohort. Although also altered in patients, auditory event-related potentials elicited during wake were unrelated to NREM metrics. Consistent with a growing literature implicating thalamocortical dysfunction in SCZ, our characterization identifies independent NREM and wake EEG biomarkers that may index distinct aspects of SCZ pathophysiology and point to multiple neural mechanisms underlying disease heterogeneity. This study lays the groundwork for evaluating these neurophysiological markers, individually or in combination, to guide efforts at treatment and prevention as well as identifying individuals most likely to benefit from specific interventions.

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“…Discrepant findings have also been reported for associations between dMMN amplitude and cognitive functions in SCZ, FEP and CHR. Most studies reported significant correlations between lower dMMN amplitude and impairments in several cognitive domains, such as reasoning [ 184 ], problem solving [ 184 ], verbal fluency [ 166 , 182 ], verbal learning [ 115 , 169 , 186 , 187 ], vigilance [ 192 ], visual attention [ 180 , 186 , 188 ], attentional switching [ 186 ], executive functioning [ 194 ], contextual processing [ 178 ], working memory [ 96 , 115 , 166 , 179 , 191 , 193 ], speed of processing [ 169 , 180 , 189 ], non-verbal memory [ 96 ], social perception [ 195 ], social cognition [ 96 , 181 ], abstraction and thought flexibility [ 96 ], emotion affective prosody [ 183 , 195 ], as well as composite cognitive scores [ 167 , 190 ]. An innovative longitudinal machine learning study [ 90 ] carried out in FEP subjects, used a combination of clinical, functional, cognitive and several EEG indices (delta, theta and alpha event-related activity and dMMN amplitude values recorded at multiple electrodes).…”

Section: Resultsmentioning

confidence: 99%

Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

et al. 2022

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Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to their presence throughout different illness stages and their impact on functioning. Abnormalities in electrophysiology (EEG) measures are highly related to these impairments, but the use of EEG indices in clinical practice is still limited. A systematic review of articles using Pubmed, Scopus and PsychINFO was undertaken in November 2021 to provide an overview of the relationships between EEG indices and cognitive impairment in schizophrenia-spectrum disorders. Out of 2433 screened records, 135 studies were included in a qualitative review. Although the results were heterogeneous, some significant correlations were identified. In particular, abnormalities in alpha, theta and gamma activity, as well as in MMN and P300, were associated with impairments in cognitive domains such as attention, working memory, visual and verbal learning and executive functioning during at-risk mental states, early and chronic stages of schizophrenia-spectrum disorders. The review suggests that machine learning approaches together with a careful selection of validated EEG and cognitive indices and characterization of clinical phenotypes might contribute to increase the use of EEG-based measures in clinical settings.

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Longitudinal relationships between mismatch negativity, cognitive performance, and real-world functioning in early psychosis

Cited by 16 publications

References 80 publications

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

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