Longitudinal Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) Derived Metrics in the White Matter

Lehmann, Nico; Aye, Norman; Kaufmann, Jörn; Heinze, Hans‐Jochen; Düzel, Emrah; Ziegler, Gabriel; Taubert, Marco

doi:10.1016/j.neuroscience.2021.01.005

Cited by 23 publications

(23 citation statements)

References 122 publications

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“…A study by Andica et al (2020) shows good (intraclass correlation coefficient [ICC] > 0.75) to excellent (ICC > 0.90) within-session reliability of NODDI markers in both white and gray matter. This was confirmed by Lehmann et al (2021) who reported 4-week reliabilities in a similar range (ICC > 0.75). Unfortunately, Lehmann et al (2021) only investigated white matter.…”

Section: Residuals Of the Neo-pi-r Depression Scoresupporting

confidence: 64%

“…This was confirmed by Lehmann et al (2021) who reported 4-week reliabilities in a similar range (ICC > 0.75). Unfortunately, Lehmann et al (2021) only investigated white matter. This data suggests that NODDI is inherently reliable.…”

Section: Residuals Of the Neo-pi-r Depression Scoresupporting

confidence: 64%

“…As this toolbox was extensively validated, Lehmann et al (2021) suggest that previously reported reliability estimates can be considered as benchmarks for NODDI markers obtained using the AMICO toolbox.…”

Section: Residuals Of the Neo-pi-r Depression Scorementioning

confidence: 99%

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Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Schlüter

Fraenz

Friedrich³

et al. 2022

Human Brain Mapping

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Neuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala's structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites.We, therefore, acquired brain images from 221 healthy participants using advanced multi-shell diffusion-weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high-resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO-PI-R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism-related disorders like depression.

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Section: Residuals Of the Neo-pi-r Depression Scoresupporting

confidence: 64%

Section: Residuals Of the Neo-pi-r Depression Scoresupporting

confidence: 64%

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Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Schlüter

Fraenz

Friedrich³

et al. 2022

Human Brain Mapping

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“…While the DTI metric of FA does not make assumptions about underlying biophysical tissue properties and can be influenced by a variety of neurobiological factors, 43 , 44 NODDI metrics allow for more specific interpretation of neural structure 43 , 45 via biophysical multi-compartmental modelling to quantify diffusion characteristics. NODDI metrics have been shown to be reproducible in longitudinal samples 46 and have been validated against histological measures of neurite (e.g. axon and dendrite) structure, 47 , 48 demonstrating NODDI’s superior ability to capture nuances of neurite architecture compared to classical DTI models.…”

Section: Methodsmentioning

confidence: 99%

Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial

Surgent

Dean

Alexander

et al. 2021

Brain Communications

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The human brain has demonstrated the power to structurally change as a result of movement-based interventions. However, it is unclear whether these structural brain changes differ in autistic individuals compared to non-autistic individuals. The purpose of the present study was to pilot a randomized controlled trial to investigate brain, balance, autism symptom severity, and daily living skill changes that result from a biofeedback-based balance intervention in autistic adolescents (13–17 years old). Thirty-four autistic participants and 28 age-matched non-autistic participants underwent diagnostic testing and pre-training assessment (neuroimaging, cognitive, autism symptom severity, and motor assessments) and were then randomly assigned to six weeks of a balance-training intervention or a sedentary-control condition. After the six weeks, neuroimaging, symptom severity, and motor assessments were repeated. Results found that both the autistic and non-autistic participants demonstrated similar and significant increases in balance times with training. Further, individuals in the balance-training condition showed significantly greater improvements in postural sway and reductions in autism symptom severity compared to individuals in the control condition. Daily living scores did not change with training, nor did we observe hypothesized changes to the microstructural properties of the corticospinal tract. However, follow-up voxel-based analyses found a wide range of balance-related structures that showed changes across the brain. Many of these brain changes were specific to the autistic participants compared to the non-autistic participants, suggesting distinct structural neuroplasticity in response to balance training in autistic participants. All together, these findings suggest that biofeedback-based balance training may target postural stability challenges, reduce core autism symptoms, and influence neurobiological change. Future research is encouraged to examine the superior cerebellar peduncle in response to balance training and symptom severity changes in autistic individuals, as the current study produced overlapping findings in this brain region.

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“…For NODDI, the inter-session reproducibility of NDI and ODI parameters is below 5% voxel-wise and under 2% regionally. However, ISO has above 40% voxel-wise and above 10% regional repeatability [ 124 ]. The repeatability of DKI is not widely established, but the first results report a coefficient of variation between 4% and 5.2% for both RK and MK parameters [ 125 ].…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Petr

Hogeboom

Nikulin

et al. 2021

Magn Reson Mater Phy

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Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning.This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.

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Longitudinal Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) Derived Metrics in the White Matter

Cited by 23 publications

References 122 publications

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism

Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

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