Longitudinal resting-state functional connectivity changes in the insular subdivisions of abstinent individuals with opioid use disorder

Yang, Wenhan; Wang, Shicong; Luo, Jing; Cui, Yan; Tang, Fei; Du, Yanyao; Fan, Li; Zhang, Min; Zhang, Jun; Yuan, Kai; Liu, Jun

doi:10.1016/j.psychres.2022.114808

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…While one study showed abstinence strengthened (rather than weakened) FC among ECN, SN, and DMN regions (S. Zhang, Yang, Li, Wang, et al, 2022), the change in FC was otherwise consistent in that abstinence shifted FC towards the stronger FC observed in HC vs HU. This accords with work showing that HD have weaker FC as compared with HC between key regions in the ECN (e.g., dlPFC) and DMN (e.g., IPL) (Yuan et al, 2010), and that abstinence strengthens FC among DMN, ECN, or SN regions (Yang et al, 2022).…”

Section: Discussionsupporting

confidence: 89%

Differences in fMRI-based functional connectivity during abstinence or interventions between heroin-dependent individuals and healthy controls

Kurtin,

Prabhu,

Groen

et al. 2024

Preprint

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The substantial personal, societal, and economic impacts of opioid addiction drive research investigating how opioid addiction affects the brain, and whether therapies attenuate addiction-related metrics of brain function. One useful approach to characterise the effects of opioid addiction on the brain is functional connectivity (FC). FC assesses the pairwise relationship of brain region function over time. This work is a systematic narrative review of studies investigating the effect of abstinence or interventions on FC in people who are dependent on heroin (HD) and healthy controls (HC). We found that HD typically showed weaker FC between three functional networks: the Executive Control Network, Default Mode Network, and the Salience Network. Abstinence and Transcranial Magnetic Stimulation (TMS) both attenuated differences in FC between HD and HC, often by increasing FC in HD. We critically assessed the clinical relevance of these results and the impact of study methods on the robustness of study results. We concluded with practical suggestions to improve the translational potential of neuromodulatory interventions (e.g., noninvasive brain stimulation) targeting the neural correlates of opioid addiction.HighlightsFunctional connectivity (FC) informs how neural resources are organised.FC is weaker in people with heroin dependence (HD) vs healthy controls (HC)Weaker FC is observed among resting, reward, cognitive, and attentional networks.Abstinence and brain stimulation strengthen FC and reduce craving/relapse in HD.FC may be a biomarker for developing therapies for HD.

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Section: Discussionsupporting

confidence: 89%

Differences in fMRI-based functional connectivity during abstinence or interventions between heroin-dependent individuals and healthy controls

Kurtin,

Prabhu,

Groen

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Emerging evidence shows that the insula, as a key hub of the SN, is an interoceptive signal receiver that plays a central role in the coordination of neural resources, dynamic cognitive control, and detection of behavioural stimuli [29]. Subdivisions of the insula based on whole-brain perfusion-based FC patterns showed that the anterior insula (AI) is mainly connected to the dorsal anterior cingulate, while the PI is mainly connected to the SMA and middle cingulate, which has also been reflected in anatomical connectivity patterns [30,31].…”

Section: Discussionmentioning

confidence: 99%

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Li,

Zhang,

Ren

et al. 2024

J Headache Pain

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Objective The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions and each of which plays different role in PTH neuropathology. Methods Ninety-four mTBI patients were included in this study. Based on perfusion imaging data obtained from arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI), this study evaluated the insular subregion perfusion-based functional connectivity (FC) and its correlation with clinical characteristic parameters in patients with PTH after mTBI and non-headache mTBI patients. Results The insular subregions of mTBI + PTH (mTBI patients with PTH) and mTBI-PTH (mTBI patients without PTH) group had positive perfusion-based functional connections with other insular nuclei and adjacent discrete cortical regions. Compared with mTBI-PTH group, significantly increased resting-state perfusion-based FC between the anterior insula (AI) and middle cingulate cortex (MCC)/Rolandic operculum (ROL), between posterior insula (PI) and supplementary motor area (SMA), and decreased perfusion-based FC between PI and thalamus were found in mTBI + PTH group. Changes in the perfusion-based FC of the left posterior insula/dorsal anterior insula with the thalamus/MCC were significant correlated with headache characteristics. Conclusions Our findings provide new ASL-based evidence for changes in the perfusion-based FC of the insular subregion in PTH patients attributed to mTBI and the association with headache features, revealing the possibility of potential neuroplasticity after PTH. These findings may contribute to early diagnosis of the disease and follow-up of disease progression.

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Hereditary and cortical morphological biomarker of sensitivity to reward in short-term withdrawal methamphetamine abusers

Yang,

Tang

et al. 2024

Cerebral Cortex

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Higher sensitivity to reward (SR) and weaker sensitivity to punishment (SP) construct the fundamental craving characteristics of methamphetamine abuse. However, few studies have appraised relationships between SR/SP (SR or SP) and cortical morphological alterations in methamphetamine abusers and whether hereditary factors take effects on SR/SP is unclear. Based on surface-based morphometric analysis, cortical discrepancy was investigated between 38 methamphetamine abusers and 37 healthy controls. Within methamphetamine abusers, correlation profiling was performed to discover associations among aberrant neuroimaging substrates, SR, SP, and craving. According to nine single nucleotide polymorphism sites of dopamine-related genes, we conducted univariate general linear model to find different effects of genotypes on cortical alterations and SR/SP/craving (SR, SP, or craving). Ultimately, mediation analyses were conducted among single nucleotide polymorphism sites, SR/SP/craving, and cortical morphological alterations to discover their association pathways. Compared to healthy controls, thinner cortices in inferior temporal gyrus, lateral orbitofrontal cortex, medial orbitofrontal cortex, inferior parietal lobule, and lateral occipital cortex in the left hemisphere were found in methamphetamine abusers (P < 0.05, family-wise error corrected). Cortical thickness in the inferior temporal gyrus was negatively correlated with SR scores. We found that rs1800497 A-containing genotypes had lower cortical thickness in the left inferior parietal lobule than the GG genotype. The rs5751876 had effects on SR scores. This study would provide convincing biomarkers for SR in methamphetamine abusers and offer potential genetic targets for personalizing relapse prevention.

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Longitudinal resting-state functional connectivity changes in the insular subdivisions of abstinent individuals with opioid use disorder

Cited by 3 publications

References 42 publications

Differences in fMRI-based functional connectivity during abstinence or interventions between heroin-dependent individuals and healthy controls

Differences in fMRI-based functional connectivity during abstinence or interventions between heroin-dependent individuals and healthy controls

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Hereditary and cortical morphological biomarker of sensitivity to reward in short-term withdrawal methamphetamine abusers

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