Longitudinal study of alveolitis in hypersensitivity pneumonitis patients: An immunologic evaluation

Trentin, Livio; Marcer, G; Chilosi, Marco; Zambello, Renato; Agostini, Carlo; Masciarelli, M; Bizzotto, Rosana; Gemignani, Carla; Cipriani, A; Vittorio, Giuseppe Di; Semenzato, Gianpietro

doi:10.1016/0091-6749(88)90967-0

Cited by 56 publications

(31 citation statements)

References 20 publications

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“…Because we did not use the same experimental design as Keller et al [26], the different suppressor circuits that are involved in the assays performed in the two studies may explain the different re sults. More importantly, the study popula tion evaluated by the above authors is dif ferent in terms of surface phenotype (i.e., higher number of T4+ cells and higher T4/T8 ratio), possibly mimicking that of patients with a more chronic phase of the disease [9], Thus the data reported in the two laboratories are not necessarily contradictory but may evaluate distinct phenomena.…”

Section: Evaluation Of Suppressor and Cytotoxic Functionsmentioning

confidence: 63%

“…In particular, studies on lung cells in these patients have greatly im proved since the development of hybridoma technology and the subsequent intro duction of monoclonal antibodies in clini cal research. In this brief review of im munological features related to BAL cells recovered from EAA lung we will refer to patients in the active phase of the disease; in subacute or chronic phases of the dis ease the pattern might be different [9],…”

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confidence: 99%

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Current Concepts on Bronchoalveolar Lavage Cells in Extrinsic Allergic Alveolitis

Semenzato

1988

Respiration

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Studies performed on cells recovered from bronchoalveolar lavage fluid and lung tissue sections have demonstrated that the alveolitis in patients with extrinsic allergic alveolitis is characterized by cells bearing suppressor/cytotoxic phenotype (T3 + , T8 + , HNK1 +). Functional in vitro analyses demonstrated that lung T cells from these patients are able to provide suppressor function in a pokeweed-mitogen-induced B cell differentiation assay and nonspecific cytotoxic activity. This latter property has not been observed in subjects with asymptomatic extrinsic allergic alveolitis. The expansion of cells with suppressor and cytotoxic characteristics in the lung of these patients is likely to be related to a local immunologic response to the antigenic stimulus.

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Section: Evaluation Of Suppressor and Cytotoxic Functionsmentioning

confidence: 63%

mentioning

confidence: 99%

Current Concepts on Bronchoalveolar Lavage Cells in Extrinsic Allergic Alveolitis

Semenzato

1988

Respiration

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“…Neutrophils can be seen in the lavage fluid if the procedure is performed within 48 hours after acute exposure [60]. While the neutrophil count returns to normal within one week after cessation of acute exposure, the lymphocyte count may remain elevated for years, even after apparent removal from the inciting antigen [61,62]. Concentrations of IgG, IgM, and IgA antibodies are typically increased in the BALF of patients with active HP [63,64].…”

Section: Bronchoalveolar Lavagementioning

confidence: 99%

Hypersensitivity pneumonitis

Mohr¹

2004

Current Opinion in Pulmonary Medicine

135

138

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A careful environmental and occupational history and establishment of exposure to a known inciting antigen are key factors in making the diagnosis of HP. Serum precipitating antibodies, bronchoalveolar lavage, and lung biopsy may be helpful in making the diagnosis. Avoidance of organic antigen exposure is the most important factor in the management of HP. Corticosteroids are indicated for the treatment of severe acute and subacute HP and for chronic HP that is severe or progressive. Long-term corticosteroid therapy for the treatment of chronic HP should be considered only if objective improvement in clinical signs, pulmonary function, or radiographic abnormalities is documented.

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“…Marked BAL fluid lymphocytosis is found in EAA patients. However, BAL fluid lymphocytosis often persists for years following removal from exposure and despite clinical recovery, limiting its usefulness as a tool to follow the course and progression of illness [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…BAL is useful technique for viewing the cellular profile and humoral events of EAA [22][23][24][25][26]. Marked BAL fluid lymphocytosis is found in EAA patients.…”

Section: Discussionmentioning

confidence: 99%

Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage (BAL) fluids of extrinsic allergic alveolitis

Shijubo

Imai

Shigehara

et al. 1995

Clinical and Experimental Immunology

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SUMMARYICAM-1 plays an itnportant role in inflammatory diseases. We analysed ICAM-1 expression on BAL fluid cells and measured soluble ICAM-1 (sICAM-l) concentrations in sera and BAL fluids from patients with extrinsic allergic alveolitis (EAA). We found significantly increased cellular ICAM-1 expression on BAL fluid lymphocytes and alveolar marcrophages, and significantly increased values of circulating and BAL fluid sICAM-l in EAA patients compared with controls. Successive measurement showed prompt decrease of both sICAM-1 values in EAA patients during periods when antigen exposure was prevented. In BAL fluids from EAA patients. sICAM-l values significantly correlated to neutrophil and ICAM-1"^ lymphocyte counts. In EAA patients, circulating and BAL fluid sICAM-l values has significant negative correlations to values of carbon monoxide diffusing capacity and to time intervals between last episode and sample collection. However, these values had significant positive correlation to values of alveolar-arterial oxygen pressure difference. In EAA, antigen exposure appears to induce cellular ICAM-1 expression on BAL fluid cells, and also appears to up-regulate shedding of ICAM-1 in the alveolar lining fluid and in Ihe circulation. The sICAM values appear to reflect disease activity of EAA.

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Longitudinal study of alveolitis in hypersensitivity pneumonitis patients: An immunologic evaluation

Cited by 56 publications

References 20 publications

Current Concepts on Bronchoalveolar Lavage Cells in Extrinsic Allergic Alveolitis

Current Concepts on Bronchoalveolar Lavage Cells in Extrinsic Allergic Alveolitis

Hypersensitivity pneumonitis

Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage (BAL) fluids of extrinsic allergic alveolitis

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