1999
DOI: 10.4269/ajtmh.1999.60.598
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Longitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland.

Abstract: Abstract. The maintenance of Borrelia burgdorferi in a population of Peromyscus leucopus was investigated from 202 mark and recapture mice and 61 mice that were removed from a site in Baltimore County, Maryland. Borrelia burgdorferi infection was detected by culture and polymerase chain reaction (PCR) of ear tissue, and exposure to the spirochete was quantified by serology. Overall prevalence of B. burgdorferi, as determined by culture and PCR of ear tissue at first capture, was 25% in the longitudinal sample … Show more

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Cited by 77 publications
(100 citation statements)
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“…Previous reports by Hofmeister et al (1999aHofmeister et al ( , 1992 and Markowski et al (1998) established that 29-66% of P. leucopus mice collected in Baltimore County, MD, north of our study region, were infected. Our findings, using the same gene target (ospA) as well as an additional gene target, flaB, closely agree with the 1992 study by Hofmeister et al While it is known that Microtus are competent reservoirs for B. burgdorferi, especially in areas where P. leucopus are not abundant (Markowski et al 1998), this is the first report of infection in this host collected in the mid-Atlantic region.…”
Section: Discussionsupporting
confidence: 48%
See 1 more Smart Citation
“…Previous reports by Hofmeister et al (1999aHofmeister et al ( , 1992 and Markowski et al (1998) established that 29-66% of P. leucopus mice collected in Baltimore County, MD, north of our study region, were infected. Our findings, using the same gene target (ospA) as well as an additional gene target, flaB, closely agree with the 1992 study by Hofmeister et al While it is known that Microtus are competent reservoirs for B. burgdorferi, especially in areas where P. leucopus are not abundant (Markowski et al 1998), this is the first report of infection in this host collected in the mid-Atlantic region.…”
Section: Discussionsupporting
confidence: 48%
“…Reduced populations of I. scapularis or P. leucopus or a reduction in the prevalence of infection in either population could contribute to the decline in LD cases among humans in these areas. One of the largest studies of Borrelia infection in a natural population of P. leucopus was conducted in an endemic region of northern Baltimore County, MD, where it was established that 25-42% of mice were infected with B. burgdorferi s.s. (Hofmeister et al 1995(Hofmeister et al , 1999a. Other studies conducted along the northeastern U.S. have revealed much higher rates of infection in P. leucopus (Anderson et al 1986, Anderson et al 1985, Mather et al 1989).…”
Section: Introductionmentioning
confidence: 93%
“…Within Lyme disease endemic areas, whitefooted mice (Peromyscus leucopus) are heavily parasitized by larval ticks (Mather and Ginsberg 1994, Ostfeld et al 1996a, Schmidt et al 1999, are frequently infected (Donahue et al 1987, Hofmeister et al 1999, and are highly efficient at transmitting B. burgdorferi to feeding larval ticks (Levine et al 1985, Mather et al 1989. However, the impact of mouse abundance on abundance and infection prevalence of nymphal ticks, and hence on risk of human exposure to Lyme disease, is controversial (Mather and Ginsberg 1994, Ginsberg et al 1998, Ostfeld et al 1998a, Randolph 1998).…”
Section: Introductionmentioning
confidence: 99%
“…While many studies incorporate host recovery after infection for different pathogens 269 , empirical studies on B. burgdorferi s.l. show that rodents do not recover from infection and stay infectious to feeding ticks for the rest of their lifespan 22,288 (Box 8.1; assumption 9). For B. burgdorferi s.l., infection prevalence and realized reservoir competence are strongly correlated (Chapter 2; Box 8.1; assumption 10).…”
Section: Validation Of Model Assumptionsmentioning
confidence: 99%