Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus

Siahpush, Sid H.; Vaughan, Thomas L.; Lampe, Jed N.; Freeman, Robert J.; Lewis, SKay; Odze, Robert D.; Blount, Patricia L.; Ayub, Kamran; Rabinovitch, Peter S.; Reid, Brian J.; Chen, Chu

doi:10.1158/1055-9965.epi-06-0986

Cited by 35 publications

(16 citation statements)

References 56 publications

(66 reference statements)

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“…However, the relatively good prognosis of PC (5-year relative survival of 71% in England and Wales by 2000-2001 [12]) has allowed a mean follow-up of 4-years in this study. Greater levels of IGF-I (insulin-like growth factor-I), a ''noted mitogen'', are seen in both PC [26] and OAC [27]. As this is registry data, information on risk factors such as obesity, smoking, gastro-oesophageal reflux symptoms and diet are unfortunately not available.…”

Section: Discussionmentioning

confidence: 99%

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Cooper

Croft

Day

et al. 2009

Cancer Causes Control

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Oesophageal adenocarcinoma (OAC) is more common in men. Androgens may therefore contribute to the pathogenesis of OAC. Prostate cancer (PC), an androgen sensitive tumor with a long natural history, may allow insights into this putative association. West Midlands Cancer Intelligence Unit data from 1977 to 2004 were examined to identify patients with a first malignant primary of PC. Patients were followed until diagnosis of a second primary cancer, death or end of the time period. Age- and period-adjusted standardized incidence ratios (SIR) were calculated as an estimate of the relative risk of a second malignant primary of the oesophagus. Between 1977 and 2004, 44,819 men within the West Midlands developed PC as a first primary malignancy. After exclusion for lack of follow-up, 38,627 men were eligible, providing 143,526 person years at risk for analysis. 86 second primary oesophageal cancers were observed, compared with 110 expected, resulting in an SIR of 0.78 (95% CI 0.62-0.96). There was a reduced risk of OAC 0.7 (0.5-0.95) but not of oesophageal squamous cell carcinoma (OSCC) 1.03 (0.69-1.47). The risk of developing OAC, but not OSCC, is lower than expected in patients with PC. A diagnosis of PC may be associated with aetiological factors that are negatively associated with OAC, or anti-androgen therapy may influence the development of OAC.

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Section: Discussionmentioning

confidence: 99%

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Cooper

Croft

Day

et al. 2009

Cancer Causes Control

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“…The expression of IGFBP-3 has been reported to be repressed by polymorphism or hypermethylation in the promoter region of the gene [27][28][29]31]. The polymorphism of −202 A > C has most intensively been studied in various cancers, and has been shown to be significantly related to decrease of circulating IGFBP-3 levels [19,28,29,35,36] as well as increase of breast cancer risk in Caucasians [27]. However, polymorphisms among the epigenetic changes of IGFBP-3 gene that confers individual susceptibility to lung cancer have rarely been examined so far [32].…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population

et al. 2008

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“…38 The IGF pathway might also be involved in the risk of progression from Barrett’s esophagus to EAC. 39 …”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma

2015

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Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence in Western cultures. Barrett’s esophagus (BE) is the presumed precursor lesion for this cancer. Several other risk factors for this cancer have been described, including chronic heartburn, tobacco use, Caucasian race, and obesity. Despite these known associations, most patients with EAC present with symptoms of dysphagia from late-stage tumors—only a small minority of patients are identified in screening and surveillance programs. Diagnostic analysis of EAC usually commences with upper endoscopy, followed by cross-sectional imaging. Endoscopic ultrasound is useful to assess local extent of disease as well as the involvement regional lymph nodes. T1a EAC may be treated endoscopically; some patients with T1b disease might also benefit from endoscopic therapy. Locally advanced disease is generally managed with esophagectomy, often accompanied by neoadjuvant chemoradiotherapy or chemotherapy. The prognosis is based on tumor stage: patients with T1a tumors have an excellent prognoses, whereas few patients with advanced disease have longterm survival.

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Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus

Cited by 35 publications

References 56 publications

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population

Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma

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