Longitudinal study of neonatal brain tissue volumes in preterm infants and their ability to predict neurodevelopmental outcome

Gui, Laura; Loukas, Serafeim; Lazeyras, François; Hüppi, Petra Susan; Meskaldji, Djalel Eddine; Tolsa, Cristina Borradori

doi:10.1016/j.neuroimage.2018.06.034

Cited by 73 publications

(55 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We quantified rapid postnatal brain growth consistent with previous imaging and post-mortem studies which have described dynamic changes in the size, organisation and complexity of the human brain during the perinatal period 17,[25][26][27][28][29][30][31] . Abrupt preterm extrauterine exposure represents a significant stressor leading to widespread deviations from the normative trajectory of brain growth with a wide range of neurodevelopmental consequences [32][33][34][35][36] .…”

Section: Discussionmentioning

confidence: 98%

Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

Dimitrova

Arulkumaran

Carney

et al. 2020

Preprint

View full text Add to dashboard Cite

ObjectivePreterm birth carries a significant risk for atypical development. While studies comparing group means have identified a number of early brain correlates of prematurity, they may ‘average out’ effects significant in a single individual. To understand better the cerebral consequences of prematurity, we created normative ‘growth curves’ characterizing neonatal brain development and explored the effect of preterm birth and related clinical risks in individual infants.MethodsWe used Gaussian process regression to map typical volumetric development in 275 healthy term-born infants, modelling for age at scan and sex. We compared magnetic resonance images of 89 preterm infants (born 28.7–34 weeks gestational age) scanned at term-equivalent age to these normative charts and related deviations from typical volumetric development to both perinatal clinical variables and neurocognitive scores at 18 months. We then tested if this approach can be generalized to an independent dataset of 253 preterm infants (born 28–31.6 weeks gestational age) also scanned at term-equivalent age but using different acquisition parameters and scanner, who were followed-up at 20 months.ResultsIn both preterm cohorts, cerebral atypicalities were widespread and often multiple, but varied highly between individual infants. Deviations from normative brain volumetric development were associated with perinatal factors including respiratory support, nutrition and postnatal growth, as well as with later neurocognitive outcome.ConclusionGroup-level understanding of the preterm brain might disguise a large degree of individual differences. We provide a method and a normative dataset for clinicians and researchers to profile the individual brain. This will allow a more precise characterization of the cerebral consequences of prematurity and improve the predictive power of neuroimaging.

show abstract

Section: Discussionmentioning

confidence: 98%

Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

Dimitrova

Arulkumaran

Carney

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…These studies have allowed us to identify altered global brain tissue growth rates in preterm infants (Gui et al. ), and have identified microstructurally altered brain white matter networks in the associative and limbic cortico‐basal ganglia‐thalamocortical circuits, involving the dorsolateral prefrontal cortex, the orbitofrontal cortex and the amygdala (Fischi‐Gomez et al. ; Cismaru et al.…”

Section: Imaging the Origins Of Neurodevelopmental Disabilitymentioning

confidence: 99%

New insights into the development of the human cerebral cortex

et al. 2019

View full text Add to dashboard Cite

The cerebral cortex constitutes more than half the volume of the human brain and is presumed to be responsible for the neuronal computations underlying complex phenomena, such as perception, thought, language, attention, episodic memory and voluntary movement. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are unique or highly derived in humans. Many human psychiatric and neurological conditions have developmental origins but cannot be studied adequately in animal models. The human cerebral cortex has some unique genetic, molecular, cellular and anatomical features, which need to be further explored. The Anatomical Society devoted its summer meeting to the topic of Human Brain Development in June 2018 to tackle these important issues. The meeting was organized by Gavin Clowry (Newcastle University) and Zoltán Molnár (University of Oxford), and held at St John's College, Oxford. The participants provided a broad overview of the structure of the human brain in the context of scaling relationships across the brains of mammals, conserved principles and recent changes in the human lineage. Speakers considered how neuronal progenitors diversified in human to generate an increasing variety of cortical neurons. The formation of the earliest cortical circuits of the earliest generated neurons in the subplate was discussed together with their involvement in neurodevelopmental pathologies. Gene expression networks and susceptibility genes associated to neurodevelopmental diseases were discussed and compared with the networks that can be identified in organoids developed from induced pluripotent stem cells that recapitulate some aspects of in vivo development. New views were discussed on the specification of glutamatergic pyramidal and γ‐aminobutyric acid (GABA)ergic interneurons. With the advancement of various in vivo imaging methods, the histopathological observations can be now linked to in vivo normal conditions and to various diseases. Our review gives a general evaluation of the exciting new developments in these areas. The human cortex has a much enlarged association cortex with greater interconnectivity of cortical areas with each other and with an expanded thalamus. The human cortex has relative enlargement of the upper layers, enhanced diversity and function of inhibitory interneurons and a highly expanded transient subplate layer during development. Here we highlight recent studies that address how these differences emerge during development focusing on diverse facets of our evolution.

show abstract

“…A longitudinal study from 18 to 24 months and then at five years of age showed that the perinatal brain characteristics of preterm infants may influence later functional development. In addition, prematurity and perinatal risk factors found in the sample had an impact on brain tissue volumes and their growth between birth and equivalent term age 41 . These findings emphasize the need for multiprofessional follow-up in order to observe the child's overall development and not in a fragmented or isolated area.…”

Section: Discussionmentioning

confidence: 97%

Description of the linguistic and neurological findings of twins born preterm at twoyears of age

Souza

Casais-e-Silva

Sena

2019

jhgd

View full text Add to dashboard Cite

Introduction: Prematurity, low birth weight and multiple births are risk factors for structural changes in the brain, as well as deviations in motor, cognitive, social and language development. Objective: To describe language findings and investigate the presence of neurological changes in preterm twins born at two years of age. Method: This is a cross-sectional study based on data analysis of the medical records of six pairs of low birth weight preterm twins, of both sexes, at two years of age, attended to at the State Center for the Prevention and Rehabilitation of Persons withDisabilities - CEPRED, in Salvador-Bahia-Brazil. To this end, information regarding birth was collected; the clinical history; the imaging exams; and the speech, neurological and interdisciplinary assessments. Results: preterm twins had atypical language development and neurological changes that may compromise oral language development. From the neurological point of view, abnormalities common to the premature newborn, such as peri-intraventricular hemorrhage, were observed. Conclusion: Multiple births associated with prematurity and low birth weight may pose risks to the childs language acquisition.

show abstract

Longitudinal study of neonatal brain tissue volumes in preterm infants and their ability to predict neurodevelopmental outcome

Cited by 73 publications

References 70 publications

Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

Phenotyping the preterm brain: characterising individual deviations from normative volumetric development in two large infant cohorts

New insights into the development of the human cerebral cortex

Description of the linguistic and neurological findings of twins born preterm at twoyears of age

Contact Info

Product

Resources

About