Longitudinal Study of the Impact of Psychological Distress Symptoms on New-Onset Upper Gastrointestinal Symptoms in World Trade Center Responders

Litcher‐Kelly, Leighann; Lam, Yvette; Broihier, Julie; Brand, Douglas L.; Banker, Suvin V.; Kotov, Roman; Bromet, Evelyn J.; Bucobo, Juan Carlos; Shaw, Robert D.; Luft, Benjamin J.

doi:10.1097/psy.0000000000000116

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…With respect to gastrointestinal disease, anxiety and depression in adults were suggested as significant independent predictors not only of functional gastrointestinal disorders, such as irritable bowel disease and functional dyspepsia,33 but also structural gastrointestinal disorders such as Crohn's disease and peptic ulcer 34. Additionally, a significant dose-response relationship, which means that adults with more co-occurring psychological disorders were associated with increased onset of new gastrointestinal symptoms, was reported in a general adult population 35. Recently, the prospective association between anxiety disorders and the incidence of gastrointestinal disease was also suggested in an older population 10.…”

Section: Discussionmentioning

confidence: 91%

Impact of Anxiety and Depression on Physical Health Condition and Disability in an Elderly Korean Population

Kang

Bae

Kim

et al. 2017

Psychiatry Investig

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ObjectiveThis study aimed to investigate the longitudinal effects of anxiety, depression, and their comorbidity on physical disorders and disability in an elderly Korean population.MethodsIn total, 1,204 community-dwelling elders were evaluated at baseline, and of these 909 (75%) were re-assessed two years later. Anxiety and depression were identified at baseline using questions from the community version of the Geriatric Mental State diagnostic schedule (GMS-B3). Participants were assessed for functional disability and for 11 physical disorders both at baseline and at follow-up.ResultsAnxiety alone was associated with the incidence of heart disease, depression alone with the incidence of asthma, and comorbid anxiety and depression with incidence of eyesight problem, persistent cough, asthma, hypertension, heart disease, and gastrointestinal problems. Comorbid anxiety and depression were associated with an increase in the number of physical disorders and the degree of disability during the two-year follow-up, compared to anxiety or depression alone or the absence of anxiety or depression.ConclusionAnxiety, depression, and particularly their comorbidity should be assessed in the elderly population considering their longitudinal effects on physical disorders and disability. Future study is required to determine whether interventions aimed at these disorders can mitigate their impacts.

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Section: Discussionmentioning

confidence: 91%

Impact of Anxiety and Depression on Physical Health Condition and Disability in an Elderly Korean Population

Kang

Bae

Kim

et al. 2017

Psychiatry Investig

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“…Furthermore, 21% of the WTC exposure effect (high vs. low intensity) on GERD was mediated by a prior OAD diagnosis [ 52 ]. Litcher-Kelly et al (2014) found that psychological distress, including depression, PTSD, panic, and anxiety, reported 3 to 4 years after 9/11 increased the risk of reporting new-onset upper GI symptoms, approximately 6 years after 9/11, in both police and nontraditional WTC responders [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster

Gargano

Mantilla

Fairclough

et al. 2018

IJERPH

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After the World Trade Center attacks on 11 September 2001 (9/11), multiple cohorts were developed to monitor the health outcomes of exposure. Respiratory and cancer effects have been covered at length. This current study sought to review the literature on other physical conditions associated with 9/11-exposure. Researchers searched seven databases for literature published in English from 2002 to October 2017, coded, and included articles for health condition outcome, population, 9/11-exposures, and comorbidity. Of the 322 titles and abstracts screened, 30 studies met inclusion criteria, and of these, 28 were from three cohorts: the World Trade Center Health Registry, Fire Department of New York, and World Trade Center Health Consortium. Most studies focused on rescue and recovery workers. While many of the findings were consistent across different populations and supported by objective measures, some of the less studied conditions need additional research to substantiate current findings. In the 16 years after 9/11, longitudinal cohorts have been essential in investigating the health consequences of 9/11-exposure. Longitudinal studies will be vital in furthering our understanding of these emerging conditions, as well as treatment effectiveness.

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“…Although many previous studies have suggested that PTSD is a risk factor for asthma and other respiratory symptoms after 9/11 exposure [Niles et al, ; Shiratori and Samuelson, ; Jordan et al, ], few assessed the direction of causality between PTSD and GERS [Litcher‐Kelly et al, ]. Litcher‐Kelly et al [] reported that the risk of new‐onset heartburn and reflux approximately 6 years after 9/11 was three times higher among participants who had PTSD 3–4 years after 9/11 than among those without PTSD. Consistent with this, we found an association between PTSD and subsequent late‐onset GERS independent of asthma and other risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Links between GERD and depression or anxiety [Jansson et al, ], and between GERD and PTSD [Litcher‐Kelly et al, ], have been noted as well. It is theorized that stress may cause changes in the brain that sensitize pain receptors and thus heighten awareness of slight increases in gastric acid levels [Fass et al, ].…”

Section: Introductionmentioning

confidence: 99%

Effect of asthma and PTSD on persistence and onset of gastroesophageal reflux symptoms among adults exposed to the September 11, 2001, terrorist attacks

Brackbill

Jordan

et al. 2016

American J Industrial Med

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Longitudinal Study of the Impact of Psychological Distress Symptoms on New-Onset Upper Gastrointestinal Symptoms in World Trade Center Responders

Abstract: In this large sample of WTC responders, psychological distress symptoms assessed at 3 years after 9/11 are related to reporting upper GI symptoms 6 years after 9/11.

Cited by 15 publications

References 27 publications

Impact of Anxiety and Depression on Physical Health Condition and Disability in an Elderly Korean Population

Impact of Anxiety and Depression on Physical Health Condition and Disability in an Elderly Korean Population

Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster

Effect of asthma and PTSD on persistence and onset of gastroesophageal reflux symptoms among adults exposed to the September 11, 2001, terrorist attacks

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