Longitudinal study of vascular structure and function during normal pregnancy

Iacobaeus, Charlotte; Andolf, Ellika; Thorsell, Malin; Bremme, Katarina; Jörneskog, Gun; Östlund, Eva; Kahan, Thomas

doi:10.1002/uog.17326

Cited by 46 publications

(43 citation statements)

References 46 publications

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“…; Iacobaeus et al. ), although the nadir in pulse wave velocity was earlier in pregnancy than the peak in global arterial compliance.…”

Section: Discussionmentioning

confidence: 94%

“…; Iacobaeus et al. ). We further showed elevated round‐trip travel time from major reflection sites and reduced systolic duration of reflected waves resulting in decreased left ventricular wasted energy due to reflected waves.…”

Section: Discussionmentioning

confidence: 98%

“…; Iacobaeus et al. ), elevated global arterial compliance and reduced central and peripheral pulse wave velocities during pregnancy. Of further note, we observed significant differences in the magnitude of many, but not all wave reflection indices obtained from carotid artery pressure waveforms used as a surrogate for aortic pressures waveforms versus aortic pressure waveforms synthesized from radial artery pressure waveforms using a generalized transfer function.…”

Section: Discussionmentioning

confidence: 99%

“…; Iacobaeus et al. ). Organs such as the brain, kidney, and heart are exposed to central aortic blood pressures, the magnitude of which is a strong predictor of adverse cardiovascular outcomes in nonpregnant individuals with and without hypertension (Vlachopoulos et al.…”

Section: Introductionmentioning

confidence: 98%

“…Pregnancy is associated with marked changes in the maternal cardiovascular system especially during the first trimester. Several studies serially examined changes in central aortic blood pressures and augmentation index during human pregnancy beginning with a pre-conception control (Table 1) (Robb et al 2009;Fujime et al 2012;Mahendru et al 2014;Foo et al 2017;Iacobaeus et al 2017). Organs such as the brain, kidney, and heart are exposed to central aortic blood pressures, the magnitude of which is a strong predictor of adverse cardiovascular outcomes in nonpregnant individuals with and without hypertension (Vlachopoulos et al 2010;Kollias et al 2016;Cheng et al 2017;Ochoa et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Wave reflections and global arterial compliance during normal human pregnancy

et al. 2018

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Profound changes occur in the maternal circulation during pregnancy. Routine measures of arterial function – central systolic pressure (CSP) and augmentation index (AIx) – decline during normal human pregnancy. The objectives of this study were twofold: (1) explore wave reflection indices besides CSP and AIx that are not routinely reported, if at all, during normal human pregnancy; and (2) compare wave reflection indices and global arterial compliance (gAC) obtained from carotid artery pressure waveforms (CAPW) as a surrogate for aortic pressure waveforms (AOPW) versus AOPW synthesized from radial artery pressure waveforms (RAPW) using a generalized transfer function. To our knowledge, a comparison of these two methods has not been previously evaluated in the context of pregnancy. Ten healthy women with normal singleton pregnancies were studied using applanation tonometry (SphygmoCor) at pre‐conception, and then during 10–12 and 33–35 gestational weeks. CSP and AIx declined, and gAC increased during pregnancy as previously reported. As a consequence of the rise in gAC, the return of reflected waves of lesser magnitude from peripheral reflection sites to the aorta was delayed that, in turn, reduced systolic duration of reflected waves, augmentation index, central systolic pressure, LV wasted energy due to reflected waves, and increased brachial‐central pulse pressure. For several wave reflection indices, those derived from CAPW as a surrogate for AOPW versus RAPW using a generalized transfer function registered greater gestational increases of arterial compliance. This discordance may reflect imprecision of the generalized transfer function for some waveform parameters, though potential divergence of carotid artery and aortic pressure waveforms during pregnancy cannot be excluded.

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“…; Iacobaeus et al. ), although the nadir in pulse wave velocity was earlier in pregnancy than the peak in global arterial compliance.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Wave reflections and global arterial compliance during normal human pregnancy

et al. 2018

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Are fetal microchimerism and circulating fetal extracellular vesicles important links between spontaneous preterm delivery and maternal cardiovascular disease risk?

Bonney,

Lintao,

Zelop

et al. 2024

BioEssays

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Trafficking and persistence of fetal microchimeric cells (fMCs) and circulating extracellular vesicles (EVs) have been observed in animals and humans, but their consequences in the maternal body and their mechanistic contributions to maternal physiology and pathophysiology are not yet fully defined. Fetal cells and EVs may help remodel maternal organs after pregnancy‐associated changes, but the cell types and EV cargos reaching the mother in preterm pregnancies after exposure to various risk factors can be distinct from term pregnancies. As preterm delivery‐associated maternal complications are rising, revisiting this topic and formulating scientific questions for future research to reduce the risk of maternal morbidities are timely. Epidemiological studies report maternal cardiovascular risk as one of the major complications after preterm delivery. This paper suggests a potential link between fMCs and circulating EVs and adverse maternal cardiovascular outcomes post‐pregnancies, the underlying mechanisms, consequences, and methods for and how this link might be assessed.

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