2022
DOI: 10.2478/jvetres-2022-0071
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Longitudinal study on seroreactivity of goats exposed to colostrum and milk of small ruminant lentivirus–infected dams

Abstract: Introduction Small ruminant lentivirus (SRLV) causes caprine arthritis-encephalitis in goats and maedi-visna disease in sheep. Transmission is via ingestion of colostrum and milk from infected dams or long-term direct contact between animals. Lifelong seroconversion can occur several weeks after infection via ingestion. However, sub-yearling lambs that ingest contaminated colostrum may be able to clear the infection and become seronegative. Whether a similar phenomenon occurs in goats remains… Show more

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Cited by 4 publications
(3 citation statements)
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“…First of all, it was made by mixing milk samples from seronegative and strongly seropositive goats while not all SRLV infected goats are strongly seropositive. In fact, the levels of antibodies against SRLV are known to fluctuate [3][4][5] which is likely to blur the differences between situations in which 1 strongly seropositive goats or several weakly seropositive goats are present in a herd. The study of Mazzei et al [41] shows that when the variability coming from different antibody concentrations in individual milk samples is eliminated by using still the same positive and negative milk sample to prepare milk dilutions, the correlation between OD value and proportion of seropositive parts of milk in the pooled sample is virtually perfect.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…First of all, it was made by mixing milk samples from seronegative and strongly seropositive goats while not all SRLV infected goats are strongly seropositive. In fact, the levels of antibodies against SRLV are known to fluctuate [3][4][5] which is likely to blur the differences between situations in which 1 strongly seropositive goats or several weakly seropositive goats are present in a herd. The study of Mazzei et al [41] shows that when the variability coming from different antibody concentrations in individual milk samples is eliminated by using still the same positive and negative milk sample to prepare milk dilutions, the correlation between OD value and proportion of seropositive parts of milk in the pooled sample is virtually perfect.…”
Section: Discussionmentioning
confidence: 99%
“…SRLV infection is lifelong and in a proportion of goats progresses into a symptomatic form, with chronic arthritis being the most common clinical manifestation. Antibodies specific to SRLV are usually produced 4 to 12 weeks post infection, rarely later [1,2], and remain detectable for life although their levels are known to fluctuate [3][4][5]. It makes serology the mainstay of CAE diagnostics [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…The virus can be transmitted vertically from infected goats to their offspring during pregnancy and postnatally via the ingestion of colostrum or milk. Another form of transfer is horizontally through long-term contact between infected animals [ 234 , 235 ]. CAEV infects various tissues and cells in the body, leading to arthritis and inflammation in the joints, as well as neurological symptoms such as encephalitis.…”
Section: Which Animal Retroviruses From the Family Orthoret...mentioning
confidence: 99%