Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

Li, Xia; Ploner, Alexander; Wang, Yunzhang; Magnusson, Patrik K. E.; Reynolds, Chandra A.; Finkel, Deborah; Pedersen, Nancy L.; Jylhävä, Juulia; Hägg, Sara

doi:10.7554/elife.51507

Cited by 241 publications

(219 citation statements)

References 35 publications

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“…Biological aging seems to be differently manifested at certain cellular levels, as suggested by the range of correlations among the biological clocks considered in this study. Consistent with prior studies we showed weak correlations between different biological clocks 26 and we confirm the absent relationship between telomere length and the epigenetic clock 21,27,28 , but also show lack of associations with the transcriptomic, proteomic or metabolomic clocks. However, we do confirm an earlier finding showing a significant but modest correlation between epigenetic and transcriptomic age 29 .…”

Section: Discussionsupporting

confidence: 92%

An integrative study of five biological clocks in somatic and mental health

Jansen

Verhoeven

Han

et al. 2020

Preprint

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1 5 15 20 ABSTRACT Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illnesses and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether 5 biological clocks (telomere length, epigenetic, transcriptomic, proteomic and metabolomic clocks) were interrelated and associated to somatic and mental health determinants.Correlations between biological clocks were small (all r<0.2), indicating little overlap. The most consistent associations with the advanced biological clocks were found for male sex, higher BMI, metabolic syndrome, smoking and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological clocks, indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels. 2 30 35 40 45

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Section: Discussionsupporting

confidence: 92%

An integrative study of five biological clocks in somatic and mental health

Jansen

Verhoeven

Han

et al. 2020

Preprint

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“…In general, weight loss in late life was associated with an increased mortality [8]. Malnutrition in older adults with cancer may diminish tolerance to therapy and result in a worse response to treatment [9].…”

Section: Management Of Older Adult Cancer Patientsmentioning

confidence: 99%

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

et al. 2020

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The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer. In this review, we present problems associated with the diet and nutrition in the elderly undergoing active cancer therapy and provide some information on epigenetic aspects of aging and cancer transformation. Nutritional interventions modulating the epigenetic profile, including caloric restriction and basal diet with modifications (elimination diet, supplementary diet) are discussed as the ways to improve the efficacy of cancer therapy and maintain the quality of life of older adults with cancer.

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“…Two such predictors, termed PhenoAge (a DNAm predictor trained on a measure that itself was trained on mortality, using 42 clinical measures and age as input features) and GrimAge (trained on mortality, including a DNAm measure of smoking as a constituent part), outperform both Hannum and Horvath clocks in predicting mortality, and are associated with various measures of morbidity and lifestyle factors [15,16]. DNAm GrimAge outperforms PhenoAge and the first generation of epigenetic clocks when it comes to predicting time to death [8,17,18].…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

McCartney¹,

Min²,

Richmond³

et al. 2020

Preprint

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AbstractBiological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic architecture underlying epigenetic ageing and its shared genetic contributions with lifestyle factors and longevity.

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Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

Cited by 241 publications

References 35 publications

An integrative study of five biological clocks in somatic and mental health

An integrative study of five biological clocks in somatic and mental health

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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