Longitudinal trends in nutritional status and the relation between lung function and BMI in cystic fibrosis: a population-based cohort study

Stephenson, Anne L.; Mannik, Lisa A.; Walsh, Shirley; Brotherwood, Michelle; Robert, Ronalee; Darling, Pauline B.; Nisenbaum, Rosane; Moerman, Joost; Stanojevic, Sanja

doi:10.3945/ajcn.112.051409

Cited by 136 publications

(138 citation statements)

References 25 publications

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“…Patients homozygous for delta F508 had lower BMI percentile (21.9±23.3°; p=0.017), value lower than that considered acceptable (BMI ≥25°), according to the American Consensus on Nutrition for cystic fibrosis 18 . This result corroborates other studies, which despite using other indicators (weight, height, weight and height percentile for age, and weight and BMI Z-scores) found values lower than those obtained in the present study when delta F508 mutation was present [5][6][7][8] . The latest recommendation for patients with cystic fibrosis is that the BMI should be maintained as far as possible above 50°1 3 , and in general, the sample average value was not close to that value (33.0°±27.9).…”

Section: Discussionsupporting

confidence: 50%

“…Although there are studies addressing the relation between delta F508 mutation and nutritionrelated phenotypes in cystic fibrosis, such as poor nutritional status [5][6][7][8] , high energy consumption 9,10 , presence of Mellitus diabetes 11 , and decreased levels of essential fatty acids 12 , these factors have not been entirely elucidated yet.…”

Section: Introductionmentioning

confidence: 99%

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Nutrional status and dietary factors in cystic fibrosis patients with delta F508 mutation

Santos

Steemburgo

2015

Rev. Nutr.

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Objective To examine the association between nutritional status and dietary factors in children and adolescents with cystic fibrosis that are carriers of delta F508 mutation. Methods Cross-sectional study of cystic fibrosis children and adolescents. Nutritional status (body mass index percentile) and dietary intake (3-day diet records presented as a percentage of estimated energy requirement) were assessed. Results Thirty six patients (median of 8.6; interquartile range 6.8-12.5 years; 50% male). The Poisson regression analysis showed that the carriers for delta F508 mutation had 60% lower prevalence ratio of body mass index ≥25° (PR=0.4; 95%IC=0.2-0.8) and 90% lower prevalence ratio (PR=0.1; confidence interval 95%IC=0.02-0.3) of ≥150% of estimated energy requirement when compared with non-delta F508 mutation carriers. The model was adjusted for lung function, estimated energy requirement, and body mass index. Conclusion Carriers for delta F508 mutation showed lower body mass index percentile and lower daily caloric consumption when compared with patients without this mutation.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Nutrional status and dietary factors in cystic fibrosis patients with delta F508 mutation

Santos

Steemburgo

2015

Rev. Nutr.

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“…, 24 - 26 Growth and nutrition are two intimately linked characteristics, so, since better nutrition is associated to better lung function in CF, maintaining a healthy nutritional status is important not only for nutrition and growth, but for lung function as well 27. Stephenson et al28 studied a cohort of 909 CF patients. Subjects in the overweight and obese categories were older and presented better lung function.…”

Section: Discussionmentioning

confidence: 99%

Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

Mauch

Kmit

Marson

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:To review the literature addressing the relationship of growth and nutritional parameters with pulmonary function in pediatric patients with cystic fibrosis.Data source:A collection of articles published in the last 15 years in English, Portuguese and Spanish was made by research in electronic databases - PubMed, Cochrane, Medline, Lilacs and Scielo - using the keywords cystic fibrosis, growth, nutrition, pulmonary function in varied combinations. Articles that addressed the long term association of growth and nutritional parameters, with an emphasis on growth, with pulmonary disease in cystic fibrosis, were included, and we excluded those that addressing only the relationship between nutritional parameters and cystic fibrosis and those in which the aim was to describe the disease.Data synthesis:Seven studies were included, with a total of 12,455 patients. Six studies reported relationship between growth parameters and lung function, including one study addressing the association of growth parameters, solely, with lung function, and all the seven studies reported relationship between nutritional parameters and lung function.Conclusions:The review suggests that the severity of the lung disease, determined by spirometry, is associated with body growth and nutritional status in cystic fibrosis. Thus, the intervention in these parameters can lead to the better prognosis and life expectancy for cystic fibrosis patients.

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“…Таким образом, восстановление нормальных значений ИМТ (18,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)9 ОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИ…”

Section: тяжелое течение муковисцидоза и трансплантация легкихunclassified

Nutritional status in patients with cystic fi brosis before and after lung transplantation

Хубутия¹,

Ильинский²,

Рык³

et al. 2017

Transplantologiâ (Mosk.)

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Longitudinal trends in nutritional status and the relation between lung function and BMI in cystic fibrosis: a population-based cohort study

Cited by 136 publications

References 25 publications

Nutrional status and dietary factors in cystic fibrosis patients with delta F508 mutation

Nutrional status and dietary factors in cystic fibrosis patients with delta F508 mutation

Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

Nutritional status in patients with cystic fi brosis before and after lung transplantation

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