Longitudinal variations and predictors of increased perceived impact of multiple sclerosis, a two-year study

High sense of coherence in adolescence is a protective factor in the longitudinal development of ADHD symptoms

“…The findings are similar with the results in studies within the field of somatic care that have shown that high SOC can work as a predictive factor for sustained health (28–30). There are also studies investigating the relationship between SOC and psychopathology.…”

Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis

“…There is some evidence that changes in EDSS scores in the context of clinical trials may partly represent temporary fluctuation in function or variations in measurement rather than sustained disability due to irreversible myelin and neuroaxonal loss [30] and it is possible that the EDSS has a limited sensitivity for detecting neurological dysfunction in secondary progressive MS. However, a number of previous studies which have good correlation between EDSS the physical component of QoL measures [9,16,[31][32][33][34][35][36][37][38][39][40][41][42] and so the lack of a correlation in this study may reflect the limited sensitivity of EDSS in this subject group in particular, in whom the selection criteria ensured a narrow baseline range. Significant correlation of MSIS-29 measures with components of the MSFC were found.…”

Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis

“…Pearson correlations were used to assess for linear relationships between FSS scores and cognitive measures, whereas ANOVA was used to examine the association between FSS categories (normal vs fatigue) and cognitive scores. Although a clinically meaningful change on the FSS has not been defined to date, changes considered to be significant in the past have ranged from 0.2 to 1.0 [39][40][41]. Thus, for the longitudinal analysis, repeat assessment FSS scores were categorized as stable, improved, and worse compared with first assessment scores by a conservative and liberal definition: a change in FSS scores of 0.5 or 1.0.…”

“…Subject demographics and multiple sclerosis (MS) characteristics considered to be significant in the past have ranged from 0.2 to 1.0[39][40][41]. Thus, for the longitudinal analysis, repeat assessment FSS scores were categorized as stable, improved, and worse compared with first assessment scores by a conservative and liberal definition: a change in FSS scores of 0.5 or 1.0.…”