Longitudinal, virological, and serological assessment of hospitalized COVID-19 patients

Signorini, Lucia; Dolci, Maria; Castelnuovo, Nicolò; Crespi, Luigia; Incorvaia, Barbara; Bagnoli, Pietro; Parapini, Silvia; Galli, Cristina; Ambrogi, Federico; Pariani, Elena; Binda, Sandro; Ticozzi, Rosalia; Ferrante, Pasquale; Delbue, Serena

doi:10.1007/s13365-021-01029-0

Cited by 3 publications

(2 citation statements)

References 50 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is unique, as only very few studies have previously reported test data from intestinal organs. Furthermore, in the few previously reported studies, nondetectable anti-SARS-CoV-2 antibody levels were shown 45,46 .…”

Section: Discussionmentioning

confidence: 88%

Long-term systemic and mucosal humoral response in SARS- CoV-2 vaccinated post-Covid-19 infected patients

Sengupta

Azharuddin

Johanna

et al. 2022

Preprint

View full text Add to dashboard Cite

Longitudinal serum samples, nasopharyngeal/nasal swabs and rectal swab samples were collected from eighty-nine individuals (median age 66 y) with SARS-CoV-2 PCR-positive test results at Linköping University Hospital. Samples were collected from the initial visit and thereafter for up to 2 years of follow-up. The presence of serum IgG and IgA against SARS-CoV-2 antigens (S1-spike, nucleocapsid, and NSP3) was analysed. Nasal and rectal swabs were tested for the presence of mucosal IgA against the outer envelope S1 spike and the nucleocapsid protein. Ninety percent of the participants were seropositive for SARS-CoV-2 recombinant proteins on Day 28 after study entry, and all (100%) were seropositive based on samples collected 2 months or later. Almost all (95%) developed serum SARS-CoV-2-neutralizing antibodies that were measurable from 6 to 24 months. The most common antibody responses (both serum IgG, mainly IgG1, and in nasal mucosa IgA) reacted with the S1-spike protein and the nucleoprotein. In samples collected from nasal tissues, IgA anti-S1 spike protein was mainly observed during 2 months of follow-up. In a subpopulation (18% of tested individuals), rectal IgA swabs showed the presence of anti-S1 spike IgA for 1 month of follow-up among the participants studied. .

show abstract

Section: Discussionmentioning

confidence: 88%

Long-term systemic and mucosal humoral response in SARS- CoV-2 vaccinated post-Covid-19 infected patients

Sengupta

Azharuddin

Johanna

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…It is worth mentioning that the proposed course of SARS-CoV-2 infection could start in upper respiratory tract infection (mainly as respiratory droplets), continue in lower respiratory tract infection (mainly as pulmonary infection) , followed by viremia and diffusion to other target organs (including the gastrointestinal tract), the latter being very important as it is associated with the theory that the spread of SARS-CoV-2 in hospitals and nursing homes could occur through fecal contamination, involving health personnel in the infection, who are usually able to protect themselves from droplets, wear masks, but less easily during direct care and hygiene of patients, where people are generally bedridden and not autonomous in the handling of their stools, so it should be reiterated in the proper use of personal protection equipment 11 .…”

Section: Letter To Editor / Carta Al Editormentioning

confidence: 99%

The enemy is the virus, not the vaccine

Valarezo-Sevilla¹,

Sarzosa-Terán²

2022

View full text Add to dashboard Cite

If we remember very superficially a little about the complex human immune system, a part of this immune system is made up of leukocytes (especially phagocytes and lymphocytes) that are responsible for detecting invaders and sending them defensive markers that adhere to them (the antibodies) and also to destroy the invaders identified by the system; In addition to the already mentioned leukocytes, our immune system is made up of various other elements such as cells, proteins, tissues and organs, which defend us against germs and microorganisms. 1, 2 Speaking specifically about the immune system and COVID-19, the events mainly involved in the immunopathogenesis of COVID-19 and the dysregulation of the immune response include lymphopenia and increased neutrophil-to-lymphocyte ratio, cytokines, lymphocyte depletion and dysfunction, antibody-dependent enhancement, and monocyte and granulocyte abnormalities. It must be emphasized that lymphopenia is an essential finding in most patients with COVID-19, particularly in those with a severe phenotype.3 It has been shown that multiple viral proteins induce T cells after infection and that T cells that have antiviral signatures related to safety and protection can be achieved by vaccination.4

show abstract

Acute gastrointestinal and post-acute COVID-19 gastrointestinal syndrome assessment on the Gastrointestinal Symptom Rating Scale scoring system: A questionnaire-based survey

Singh,

Srivastava,

Yadav

et al. 2024

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS) is the persistence of sequel of acute SARS-COV-2 infection. Persistent/acquired gastrointestinal symptoms (GI-PACS) include loss of appetite, nausea, weight loss, abdominal pain, heartburn, dysphagia, altered bowel motility, dyspepsia, and irritable bowel syndrome. The study aimed to assess the short- and long-term GI-PACS syndrome on the GSRS scale. Methods: A cross-sectional, retrospective record analysis and telephonic questionnaire-based survey were conducted at a tertiary referral center in northern India. The data incorporated patients treated from April 2021 to March 2023. Exclusion criteria were neurological disorders, dementia, inability to understand Hindi/English languages, and psychiatric problems. All patients who met the inclusion criteria were telephonically called from November 2023 to January 2024. Results: The study population was 350 recovered patients from SARS-COVID-19 illness. Forty-three responses were removed during data cleaning and removal of duplication. The data analysis of 307 participants (ICU admissions=92, non-ICU admissions=123, and outdoor treatment =92) was done. The proportion of patients not having any GI symptoms, having at least one GI symptom, and having more than one GI symptom before SARS-COV-2 illness was 3%(3/307), 4.9% (15/307), and 3.6% (11/307), respectively. The four major GI symptoms analyzed in the study were vomiting, pain in the abdomen, diarrhea, and constipation. Overall, 13% (40/307) of the study population did not have any major GI symptoms before SARS-COV-2 diseases. During acute SARS-COV-2 illness, 86.97% (267/307) of patients develop new GI symptoms. Post SARS-COV-2 illness, the overall mean GSRS score for 15 items was 2.14 ± 0.829. The acquired GI-PACS was abdominal pain syndrome (mean score 2.5190 ± SD 0.86650), constipation syndrome (mean score 2.3844 ± 0.83840), reflux syndrome (mean score 2.2866 ± 1.31889), indigestion syndrome (mean score 1.8591 ± 0.93076), and diarrhea syndrome (mean score 1.8122 ± 0.90899). Overall, fever (95.1%, P = 0.007), anosmia (45.0%, P = 0.042), cough (80.1%, P = 0.032), and hospitalization (30.0%, P = 0.003) had a more significant association with one of the major four GI symptoms during the acute phase of SARS-COV-2 illness. Home-isolated patients having loss of appetite (95.4%, P = 0.0001) had a significant association with one of the major four GI symptoms during the acute phase of SARS-COV-2 illness. Hospitalized patients having fever (80.7%, P = 0.031), breathlessness (83.8%, P = 0.003), loss of smell (97.0%, P = 0.001), and cough (82.7%, P = 0.048) had a more significant association with one of the major four GI symptoms during the acute SARS-COV-2 illness. Abdominal pain, reflux, and constipation were considered severe GI symptoms (symptom GSRS score greater than total mean GSRS score). Diarrhea and indigestion were considered mild symptoms (symptom GSRS score was less than the total mean GSRS score). The GI symptoms during acute SARS-COV-2 illness recovered in 66.1% (203/307) patients within 3 months. The respondents taking medicines for more than 1 year following SARS-COV-2 illness were 19.2%. 12.0% (37/307) of respondents suffered from persistent GI symptoms on a mean follow-up of 20.1 ± 0.82 months. Conclusion: Long-term COVID-19 syndrome frequently manifested as GI symptoms, whereas most symptoms subsided with time.

show abstract

Longitudinal, virological, and serological assessment of hospitalized COVID-19 patients

Cited by 3 publications

References 50 publications

Long-term systemic and mucosal humoral response in SARS- CoV-2 vaccinated post-Covid-19 infected patients

Long-term systemic and mucosal humoral response in SARS- CoV-2 vaccinated post-Covid-19 infected patients

The enemy is the virus, not the vaccine

Acute gastrointestinal and post-acute COVID-19 gastrointestinal syndrome assessment on the Gastrointestinal Symptom Rating Scale scoring system: A questionnaire-based survey

Contact Info

Product

Resources

About