Longitudinally extensive transverse myelitis with seropositive chikungunya

Hameed, Sajid; Memon, Mubashar; Imtiaz, Hina; Kanwar, Dureshahwar

doi:10.1136/bcr-2019-231745

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…al., 2019). Além disso, complicações neurológicas e cardiovasculares também têm sido relatadas em casos graves da doença (HAMEED et. al., 2019) e a presença do vírus Chikungunya em gestantes pode levar a complicações obstétricas, como parto prematuro e restrição de crescimento fetal (DE ANDRADE et.…”

Section: Resultsunclassified

Perspectivas Das Arboviroses No Brasil: Dengue, Zika Vírus E Chikungunya

Reis,

REIS,

BASTOS

et al. 2024

Anais Do II Congresso Brasileiro De Pesquisa E Educação Em Saúde on-Line

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É de grande importância estudo das arboviroses, como a dengue, zika e chikungunya, e de seu impacto significativo na qualidade de vida da população afetada, bem como no aspecto socioeconômico devido às hospitalizações, afastamento do trabalho e custos com tratamentos médicos. Destaca-se a necessidade de desenvolver estratégias de prevenção e controle eficazes para combater a propagação dessas doenças, com ênfase em medidas como eliminação de focos de mosquito, uso de repelentes e conscientização da população. Este trabalho menciona a relevância da dengue como a arbovirose mais comum no Brasil, seguida pela chikungunya e zika, transmitidas por mosquitos do gênero Aedes. Destaca-se a complexidade da distribuição geográfica da dengue no país, demandando estratégias adaptadas às particularidades locais para conter sua propagação. Também são abordadas as características clínicas e complicações das arboviroses, como os sintomas comuns da dengue, zika e chikungunya, além das complicações neurológicas associadas ao Zika vírus e as complicações obstétricas da chikungunya em gestantes. Por fim, destaca-se a importância do controle do vetor Aedes aegypti como principal estratégia para mitigar a propagação das arboviroses, incluindo medidas tradicionais e novas abordagens como mosquitos geneticamente modificados e tecnologias inovadoras.Palavras-chave: Arboviroses; Dengue; Zika; Chikungunya; Arboviroses no Brasil INTRODUÇÃOAs arboviroses são um grupo de doenças causadas por vírus transmitidos por artrópodes, como os mosquitos, e que apresentam um grande impacto na saúde pública em todo o mundo. Entre as arboviroses mais comuns estão a dengue, zika e chikungunya, que têm se tornado um problema cada vez mais relevante de saúde pública, principalmente em regiões tropicais e subtropicais (DE ANDRADE et. al., 2017). Segundo Sardari et al. (2020, as arboviroses têm sido responsáveis por um aumento significativo no número de casos e óbitos, tornando-se uma preocupação global.Apesar de serem causadas por diferentes vírus, as arboviroses possuem sintomas semelhantes, incluindo febre, dor de cabeça, dores nas articulações e nos músculos, além de erupções cutâneas. Essas doenças podem levar a complicações graves, como síndrome de choque, encefalite e até mesmo a morte, sendo importante que sejam tratadas precocemente. De acordo com a Organização Mundial da Saúde (OMS), as arboviroses representam uma ameaça significativa para a saúde global, afetando milhões de pessoas a cada ano.Além disso, as arboviroses têm um impacto significativo na qualidade de vida da população afetada, causando um grande impacto socioeconômico devido às hospitalizações, afastamento do trabalho e custos com tratamentos médicos. Dessa forma, é fundamental que Revista Multidisciplinar em Saúde

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Section: Resultsunclassified

Perspectivas Das Arboviroses No Brasil: Dengue, Zika Vírus E Chikungunya

Reis,

REIS,

BASTOS

et al. 2024

Anais Do II Congresso Brasileiro De Pesquisa E Educação Em Saúde on-Line

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“…Although the by which SARS-CoV-2 causes ATM (Acute Transverse Myelitis) is not yet entirely clear, an increasing number of studies have linked ATM as a neurological complication of COVID-19 [5][6] . The possible pathways through which the SARS-CoV-2 virus affects the spinal cord and causes ATM (Acute Transverse Myelitis) include direct invasion of the spinal cord, cytokine storm, and autoimmune response.…”

Section: Discussionmentioning

confidence: 99%

Triumph Over Adversity: A Case Report on Early Diagnosis and Effective Treatment of Progressive Acute Transverse Myelitis in the COVID-19 Era

Xiong,

Chen,

Xie

et al. 2023

Preprint

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Introduction: Acute Transverse Myelitis (ATM) is a rare acute inflammatory disease. Currently, there are no data on the incidence rates in China or other Asian countries. ATM can occur due to various causes, including infections, autoimmune diseases, and demyelinating diseases. The incidence of ATM related to COVID-19 is even rarer, with few reports available. The aim of the current study is to report a rare case of transverse myelitis during COVID-19 infection. Case presentation: A 65-year-old male patient developed fever, cough, and fatigue on December 25, 2022, and tested positive for COVID-19. After self-medicating, his fever subsided, but he soon experienced chest tightness and abdominal discomfort. Admitted to the emergency department on January 2, 2023, he quickly developed muscle weakness in his lower limbs, progressing to severe weakness (1/5 strength) and urinary retention. This weakness extended to his upper limbs, reducing his strength to 3-/5 and impairing his ability to use a mobile phone. Numbness also spread to his navel area. A positive Babinski sign was noted five days later. He showed significant improvement following timely diagnosis and pulse glucocorticoid therapy. Discussion: Research increasingly recognizes ATM as a neurological complication of COVID-19, though the exact mechanism of SARS-CoV-2 causing ATM is unclear. The virus may affect the spinal cord through direct invasion, cytokine storms, or autoimmune responses. ATM rapidly progresses and can cause multi-organ failure if untreated. Conclusion: No specific treatment or standard protocol exists for ATM, but corticosteroid pulse therapy, especially with methylprednisolone, has been effective in treating ATM by promoting nerve conduction and restoring neurological function.

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“…6 Myelitis related to CHIKV infection is seldom reported. 3,[7][8][9][10] Myelopathy as an isolated neurological presentation occurs infrequently (20%). 4,10 A few prior reports of diffuse, T2 hyperintense lesions involving the cord in the entirety with no significant postcontrast enhancement exist.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Post-Chikungunya–Associated Myeloneuropathy

Patwardhan

Nalini

Baishya

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Chikungunya virus (CHIKV) is an arbovirus endemic to South Asia with frequent outbreaks. A wide spectrum of neurological complications has been described in Chikungunya infections. Myeloneuropathy is a rare complication seen in Chikungunya and is proposed to have an underlying immune mediated pathogenesis. We report a case of a 45-year-old man presenting to the emergency services with acute onset of quadriparesis, breathlessness, urinary retention, profound pain, and sensory disturbances 6 weeks after the onset of high-grade fever and arthralgia. On examination, the patient had Medical Research Council grade 1 flaccid quadriparesis with prominent wasting and areflexia with distinct sensory level at T4. Immunoglobulin M CHIKV antibodies were positive, tested twice at a 1-week interval. He had notable magnetic resonance imaging (MRI) findings in the form of patchy T2 hyperintensities involving the entire length of the cervical and thoracic cord with normal brain imaging and extensive short tau inversion recovery hyperintense signal changes on muscle MRI. He was treated with five cycles of plasmapheresis and intravenous methylprednisolone followed by oral steroids for 8 weeks. At 20-week follow-up, the patient had improvement in upper limb weakness, but paraparesis persisted. The case highlights the presence of unusual MRI findings and also the importance of early recognition of after infective neurological complications, and prompt treatment with immunomodulation may be beneficial.

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Longitudinally extensive transverse myelitis with seropositive chikungunya

Cited by 10 publications

References 4 publications

Perspectivas Das Arboviroses No Brasil: Dengue, Zika Vírus E Chikungunya

Perspectivas Das Arboviroses No Brasil: Dengue, Zika Vírus E Chikungunya

Triumph Over Adversity: A Case Report on Early Diagnosis and Effective Treatment of Progressive Acute Transverse Myelitis in the COVID-19 Era

Case Report: Post-Chikungunya–Associated Myeloneuropathy

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