“…Our aim is to comment on recent literature about challenging extensive SCIs (2) , (3) , (4) , (5) . Chiew YR, et al reported the case study of a 58-year-old male, who had the diagnosis of an extensive SCI established by the contrast-enhanced thoracic spine MRI diffusion-weighted imaging and apparent diffusion coefficient (DWI and ADC) evaluations (2) . The authors emphasized the differences between longitudinally extensive lesions of SCI and neuromyelitis optica (NMO); the lack of contrast enhancement in SCI is due to disrupted blood flow, and in NMO it occurs by inflammation and the intact blood flow (2) .…”