Longterm management of Polycystic Ovarian Syndrome (PCOS)

Bates, G. Wright; Legro, Richard S.

doi:10.1016/j.mce.2012.10.029

Cited by 92 publications

(79 citation statements)

References 70 publications

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“…One year´s treatment with a third-generation oral contraceptive was associated with a median weight gain of 1.2 kg, which was evenly distributed on the upper and lower body regions and was unassociated with changes in testosterone levels (64). Currently, treatment with a second-generation oral contraceptives is often a first choice in patients with PCOS due to low thromboembolic risk (65,66), but the antiandrogen effect of newer generations of oral contraceptives could have less adverse effects on insulin resistance (67). The incidence of venous thromboembolism was 1.5-fold increased among women with PCOS not taking oral contraceptives compared with controls and twofold increased among women with PCOS who were taking combined oral contraceptives compared with controls (68).…”

Section: Cardiometabolic Disease In Pcosmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Section: Cardiometabolic Disease In Pcosmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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“…Guidelines recommend alternative dietary options (increasing dietary protein, reducing glycemic index, reducing carbohydrate) may be successful for achieving and sustaining a reduced weight but more research is needed in PCOS. 9 Present program followed the low-carbohydrate high fat (LCHF) approach which is in line with the new alternative recommendations. The structure and support within a weight-management program is crucial and may be more important than the dietary composition.…”

Section: Discussionmentioning

confidence: 82%

“…9 The importance of dietary changes cannot be overstressed. Effective approaches to nutrition and diet improve endocrine features, reproductive function and cardiometabolic risk profile -even without marked weight loss.…”

Section: Discussionmentioning

confidence: 99%

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Holistic approach in the management of PCOS: a pilot study of an online PCOS-reversal program

Mehta

Jayaraman²,

Agarwal³

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovary syndrome (PCOS) is a complex disorder that can be managed but not permanently cured. Each woman has her own PCOS symptoms and its own root causes. A number of medications are prescribed to women with PCOS. However, a holistic approach could be the best way forward in managing a disease as complex as PCOS. Authors conducted this pilot study called the Sepalika 5-petal PCOS reversal program which consisted of individualized diet plans, magnet acutherapy, fitness regimens, dietary supplements and herbal products to evaluate whether these interventions improve PCOS symptoms, insulin resistance and hyperandrogenism.Methods: A total of 30 patients were recruited online from all parts of India using the PCOS symptom quiz. Various baseline investigations were performed at recruitment. They were suggested personalized diet plans, followed by exercise videos, magnetic acutherapy and herbal and micronutrient supplements. The program spanned over a period of 90 days and patients outlook and quality of life were also assessed at the end of the program.Results: The main goal of most participants was improvement in weight and energy issues, and regularization of periods. Each of these goals were achieved in all participants of the program. Patient-reported outcomes showed a definite improvement in the quality of life of the participants at the end of 90 days.Conclusions: PCOS is a physical - sexual, psychological and social syndrome; therefore, it is necessary to taking a more holistic approach to patient care beyond treating physical symptoms. Larger studies with more objective and subjective endpoints is the way forward.

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“…Polycystic Ovarian Syndrome (PCOS) is the most common endocrine condition affecting young women where anovulation, hyperandrogenism, obesity, diabetes, and infertility are often seen (Barron, 2004;Bates & Legro, 2012;Glueck, et al, 2005;Nicholson, et al, 2010;West, et al, 2014 ). Typical clinical manifestations include hirsutism, acne, and alopecia (DuRant & Leslie, 2007).…”

Section: Literature Reviewmentioning

confidence: 99%

Practitioner’s Perspective on Barriers to Diagnosing Polycystic Ovarian Syndrome in Adolescents: A Descriptive Study

Williams¹

2014

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Polycystic Ovarian Syndrome (PCOS) is a common and reversible endocrine disorder affecting as many as 3.5-5.0 million women in the United States and has serious implications for women from adolescence to beyond menopause. PCOS is characterized by oligo-amenorrhea, anovulation, clinical, biochemical signs of hyperandrogenism, or polycystic ovaries the majority which can be identified in adolescence (ages 13-18). Although the majority of these reproductive and metabolic consequences can be identified in adolescence, diagnosis of PCOS for subsequent early intervention is still not taking place as many women are not being diagnosed until their reproductive years often after seeking the cause of their infertility. No literature could be found on barriers that contribute to the failure of early diagnosis of PCOS in adolescence. There is a gap in the literature investigating the barriers of diagnosing PCOS in adolescents. This was a descriptive study done to: (1) identify factors practitioners consider when determining the diagnosis of PCOS in adolescents (ages 13-18) and (2) identify barriers to early diagnosis of PCOS in adolescents (ages 13-18) among practitioners. Barriers to diagnose PCOS in adolescents will be explored using the Polycystic Ovarian Syndrome in Adolescence questionnaire which was developed by the researcher. The Qualtrics Survey Program was used to submit an electronic survey. Barriers for diagnosing PCOS in adolescents were acknowledged and identified by participants in this study. Because this data was mainly derived from a single group within the practice area, certified nurse practitioners, it is unclear whether these findings can be generalized to other vi practice areas within the healthcare system. Future investigations should examine whether these barriers do exist amongst other practice areas, can yield enough results to be generalized, and focus on designing interventions to improve the diagnosis of PCOS in adolescents.

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Longterm management of Polycystic Ovarian Syndrome (PCOS)

Cited by 92 publications

References 70 publications

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Holistic approach in the management of PCOS: a pilot study of an online PCOS-reversal program

Practitioner’s Perspective on Barriers to Diagnosing Polycystic Ovarian Syndrome in Adolescents: A Descriptive Study

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