Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice

Sun, Wei; Zhu, Jiahao; Qin, Guanyu; Huang, Yujie; Cheng, Siying; Chen, Zhihong; Zhang, Yeyang; Shu, Yifan; Zeng, Xiaoxiong; Guo, Renpeng

doi:10.1016/j.ijbiomac.2023.125517

Cited by 10 publications

(7 citation statements)

References 67 publications

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“…As shown in Figure 4A, the body weight of mice in all groups exhibited an upward trend without differences among groups during the 8-week experiments. The index results of the kidney, liver, and heart demonstrated that D-galactose injections slightly decreased the organ indexes of mice without statistically significant differences (Figure 4B), which was consistent with previous reports [45].…”

Section: In Vivo Antioxidant Activities Of Fp and Bp Fractions In Oli...supporting

confidence: 92%

“…Thus, the expression levels of Nrf2, HO-1, NQO1, GCLC, and Glutathione S-transferase alpha 2(GSTA2) were determined in this research. The results showed that D-galactose administration decreased the expression of Nrf2 compared to the control group (Figure 6A), which was consistent with a previous study that reported that the D-galactose treatment inhibited the translocation of Nrf2 [45]. FP treatment reversed the effect of D-galactose on the expression of Nrf2 in mice; in particular, 125 mg/kg of FPs resulted in a 2.84-fold increase in the expression of Nrf2 compared to the model group.…”

Section: Fp Fractions In Olive Leaves Activate Nrf2 Signaling In Agin...supporting

confidence: 92%

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Antioxidant Capacity of Free and Bound Phenolics from Olive Leaves: In Vitro and In Vivo Responses

Li,

Wu,

Zhang

et al. 2023

Antioxidants

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Olive leaves are rich in phenolic compounds. This study explored the chemical profiles and contents of free phenolics (FPs) and bound phenolics (BPs) in olive leaves, and further investigated and compared the antioxidant properties of FPs and BPs using chemical assays, cellular antioxidant evaluation systems, and in vivo mouse models. The results showed that FPs and BPs have different phenolic profiles; 24 free and 14 bound phenolics were identified in FPs and BPs, respectively. Higher levels of phenolic acid (i.e., sinapinic acid, 4-coumaric acid, ferulic acid, and caffeic acid) and hydroxytyrosol were detected in the BPs, while flavonoids, triterpenoid acids, and iridoids were more concentrated in the free form. FPs showed a significantly higher total flavonoid content (TFC), total phenolic content (TPC), and chemical antioxidant properties than those of BPs (p < 0.05). Within the range of doses (20–250 μg/mL), both FPs and BPs protected HepG2 cells from H2O2-induced oxidative stress injury, and there was no significant difference in cellular antioxidant activity between FPs and BPs. The in vivo experiments suggested that FP and BP treatment inhibited malondialdehyde (MDA) levels in a D-galactose-induced oxidation model in mice, and significantly increased antioxidant enzyme activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and the total antioxidant capacity (T-AOC). Mechanistically, FPs and BPs exert their antioxidant activity in distinct ways; FPs ameliorated D-galactose-induced oxidative stress injury partly via the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway, while the BP mechanisms need further study.

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Section: In Vivo Antioxidant Activities Of Fp and Bp Fractions In Oli...supporting

confidence: 92%

Section: Fp Fractions In Olive Leaves Activate Nrf2 Signaling In Agin...supporting

confidence: 92%

Antioxidant Capacity of Free and Bound Phenolics from Olive Leaves: In Vitro and In Vivo Responses

Li,

Wu,

Zhang

et al. 2023

Antioxidants

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“…The present results displayed that the relative abundance of Firmicutes decreased in the d -gal group, which was also reported in previous research studies. 17,24,25 However, several research studies reported that aging occurred accompanied by an enrichment of Firmicutes . 26,27 These inconsistencies might be ascribed to the different microbial members of the phylum Firmicutes , e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Lactobacillus was reported to be involved in regulating the stress levels of the body and alleviating aging. 25 Moreover, a positive correlation was observed in the enriched Lactobacillus with hepatic antioxidant enzymes or DEPs including Gstm5 and Gstp2, which is related to anti-oxidative stress (Fig. 8).…”

Section: Papermentioning

confidence: 91%

“…The present results displayed that the relative abundance of Firmicutes decreased in the D-gal group, which was also reported in previous research studies. 17,24,25 However, several research studies reported that aging occurred accompanied by an enrichment of Firmicutes. 26,27 These inconsistencies might be ascribed to the different microbial members of the phylum Firmicutes, e.g., Tan et al found that a high-fat diet could significantly enrich the abundance of Enterococcus that belongs to Firmicutes which showed a positive correlation with liver inflammation.…”

Section: Papermentioning

confidence: 99%

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The ameliorative mechanism of Lactiplantibacillus plantarum NJAU-01 against d-galactose induced oxidative stress: a hepatic proteomics and gut microbiota analysis

Jin,

Jia,

Yang

et al. 2024

Food Funct.

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Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

Rong,

Shen,

Shu

2024

Phytotherapy Research

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Polysaccharides are one of the most important components of traditional Chinese medicine (TCM) and have been extensively studied for their immunomodulatory properties. The functions and effects of TCM polysaccharides are closely related to the gut microbiota, making the study of their interaction a hot topic in the field of TCM metabolism. This review follows two main inquiries: first, how the gut microbiota breaks down TCM polysaccharides to produce bioactive metabolites; and second, how TCM polysaccharides reshape the gut microbiota as a carbon source. Understanding the interaction mechanism involves a challenging equation of the structural association of TCM polysaccharides with the metabolic activities of the microbiota. This review has meticulously searched, partially organized literature spanning the past decade, that delves into the interaction mechanism between TCM polysaccharides and gut microbiota. It also gives an overview of the complex factors of the elusive “polysaccharides‐bond‐bacteria‐enzyme” equation: the complexity of polysaccharide structures, the diversity of glycosidic bond types, the communal nature of metabolizing microbiota, the enzymes involved in functional degradation by microbiota, and the hierarchical roles of polysaccharide utilization locus and gram‐positive PULs. Finally, this review aims to facilitate discussion among peers in the field of TCM microbiota and offers prospects for research in related fields, paving the way for pharmacological studies on TCM polysaccharides and gut microbiota therapeutics, and providing a reference point for further clinical research.

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Lonicera japonica polysaccharides alleviate D-galactose-induced oxidative stress and restore gut microbiota in ICR mice

Cited by 10 publications

References 67 publications

Antioxidant Capacity of Free and Bound Phenolics from Olive Leaves: In Vitro and In Vivo Responses

Antioxidant Capacity of Free and Bound Phenolics from Olive Leaves: In Vitro and In Vivo Responses

The ameliorative mechanism of Lactiplantibacillus plantarum NJAU-01 against d-galactose induced oxidative stress: a hepatic proteomics and gut microbiota analysis

Interplay between traditional Chinese medicine polysaccharides and gut microbiota: The elusive “polysaccharides‐bond‐bacteria‐enzyme” equation

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