Internationalization and integration of the educational environment raises the issue of university lecturer development of professional mobility in Kazakhstan's higher education system. The aim of the study is to find an empirical approach to defining the factors for the development of lecturer professional mobility in the modern conditions of functioning of higher education in Kazakhstan. Using the cluster analysis and justification of the efficiency criterion, the researcher conducted a representative sample of 30 local universities. In order to obtain quantitative estimates of their professional mobility level, the researcher surveyed 1109 lecturers from a sample set of Kazakhstan universities. To determine the structure and factors of professional mobility and the role of the resource component in professional mobility, the researcher employed principles component analysis, which was carried out on the basis of the quantitative estimates obtained as a result of the survey. Finally, the influence of pedagogical mobility factors on the efficiency level of the university was studied using regression models made using the method of nonlinear evaluation. The results of the study are of a practical nature. To know the factors of professional mobility is fundamental for educational management as it determines the ratio of resource and process components that underlie the coordination of interests of both the employee and the university, as well as the strategy for the development of lecturers in universities. This, in turn, can significantly increase the efficiency of their activities, as well as ensure the success of integration into the world educational space.