2019
DOI: 10.1017/cjn.2018.354
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Looking Glass Syndromes: Two Sides of the Same Gene

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Cited by 2 publications
(2 citation statements)
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“…The presenting cognitive, neuropsychiatric and motor symptoms and the rate of progression of symptoms varies among patients and within family members who carry the same CSF1R mutation (14). A frontal lobe syndrome, which is characterized by cognitive impairment, neuropsychiatric changes (depression, minimal social inhibition and poor insight) and limited motor dysfunction, is usually detected during the early stages of ALSP, and some patients may exhibit mild seizures (14,53,63).…”
Section: Clinical Coursementioning
confidence: 99%
See 1 more Smart Citation
“…The presenting cognitive, neuropsychiatric and motor symptoms and the rate of progression of symptoms varies among patients and within family members who carry the same CSF1R mutation (14). A frontal lobe syndrome, which is characterized by cognitive impairment, neuropsychiatric changes (depression, minimal social inhibition and poor insight) and limited motor dysfunction, is usually detected during the early stages of ALSP, and some patients may exhibit mild seizures (14,53,63).…”
Section: Clinical Coursementioning
confidence: 99%
“…Effective scales for measurement of cognitive decline should be fully validated, have inter-relater reliability, show sensitivity to early cognitive changes as well capture decline during progression of the disease and be acceptable to both the patient and assessor (99). Reports of the performance of patients with ALSP on specific cognitive tests have been limited to case reports (63). Given these limitations and the known localization of pathology in patients with ALSP, cognitive tests probing frontal lobe functions, both cortical and subcortical, including attention, processing speed, working memory and cognitive flexibility, are of particular interest.…”
Section: Cognitive Declinementioning
confidence: 99%