Loop Diuretics

Greger, R.

doi:10.1007/978-3-642-79565-7_7

Cited by 5 publications

(2 citation statements)

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“…Article the use of acetazolamide to treat fluid overload in heart failure patients has been abandoned since the emergence of loop diuretics which are considered to be more potent [9,10]. Differently from acetazolamide, loop diuretics decreased sodium and chloride reabsorption from urine by blocking the Na + /2Cl -/K + cotransporter of the thick ascending loop of Henle [11].…”

Section: Originalmentioning

confidence: 99%

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Duta,

Zulfa,

Alina

et al. 2024

Narra X

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Acetazolamide, one of the carbonic anhydrase inhibitors, has been known to improve the efficacy of diuretic therapy in patients with in congestion heart failure. The aim this study was to investigate the effectiveness of acetazolamide when combined with loop diuretics in ameliorating diuresis and natriuresis in congestive heart failure using systematic review and meta-analysis. Randomized controlled trials (RCTs) and cohort studies were searched on PubMed, Scopus, and Embase on March 7, 2023, by using combinations of ‘acetazolamide’, ‘heart failure’ and along with their respective synonyms. The protocol had been registered on PROSPERO (CRD42023409864). The studies must investigate the effect of oral acetazolamide as the add-on to loop diuretic therapy to be included. Successful decongestion, natriuresis, and diuresis were set as the primary outcomes. The quality of the included studies was assessed using the Cochrane risk-of-bias tool for RCTs and Newcastle Ottawa Scale for observational studies. We identified 1176 titles in the initial search, and further reduced to five studies (three RCTs and two cohort studies) after in-depth screening. A total of 625 patients were recruited in the included studies published from 2015 to 2022. Results from meta-analysis revealed that acetazolamide and loop diuretics combination therapy ameliorated natriuresis (n=4; standardized means difference (SMD)=0.65; 95%CI: 0.07–1.24; p=0.03) and diuresis (n=2; SMD=0.29; 95%CI: 0.12–0.46; p=0.0009) when compared to loop diuretics alone. Acetazolamide and loop diuretics combinatorial therapy is efficacious in alleviating congestion in heart failure patients.

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Section: Originalmentioning

confidence: 99%

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Duta,

Zulfa,

Alina

et al. 2024

Narra X

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“…Loop diuretics, inhibit the Na + −K + −2Cl − cotransporter on the luminal surface of the ascending loop of Henle, thus inhibiting the reabsorption of sodium chloride (NaCl), reducing the tonicity of the interstitium, resulting in diuresis (Figure 1). 13 Due to diuresis, an increase in urine output causes a reduction in extracellular fluid, thus improving pulmonary oedema 14,15 …”

Section: Introductionmentioning

confidence: 99%

Diuretics use in the management of bronchopulmonary dysplasia in preterm infants: A systematic review

Ó Briain,

Byrne,

Dowling

et al. 2024

Acta Paediatrica

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AimBronchopulmonary dysplasia (BPD), a respiratory complication associated with neonatal prematurity, presents opportunities for pharmacological intervention due to its contributing risk factors. Despite diuretics' controversial usage in BPD treatment and varying institutional practices, this review aims to consolidate evidence from clinical trials regarding diuretic use in BPD.MethodsWe conducted a systematic review following PRISMA guidelines, searching EMBASE, Medline, Web of Science and CINAHL databases (PROSPERO 2022: CRD42022328292). Covidence facilitated screening and data extraction, followed by analysis and formatting in Microsoft Excel.ResultsAmong 430 screened records, 13 were included for analysis. Three studies assessed spironolactone and chlorothiazide combinations, two studied spironolactone and hydrochlorothiazide, while eight examined furosemide. All studies evaluated drug effects on dynamic pulmonary compliance and pulmonary resistance, serving as comparative measures in our review.ConclusionDiuretics' effectiveness in treating bronchopulmonary dysplasia remains uncertain. The limited number of identified randomised controlled trials (RCTs) hampers high‐level evidence‐based conclusions when applying the Population, Intervention, Comparison, Outcome (PICO) approach. Conducting large prospective studies of good quality could provide more definitive insights, but the rarity of outcomes and eligible patients poses challenges. Further research, primarily focusing on RCTs assessing diuretics' safety and efficacy in this population, is warranted.

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Therapie von Ödemen

Greven¹,

Kramer²

Springer-Lehrbuch

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Loop Diuretics

Cited by 5 publications

References 110 publications

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Diuretics use in the management of bronchopulmonary dysplasia in preterm infants: A systematic review

Therapie von Ödemen

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