Andhra Pradesh stands top in the aquaculture production in India and shrimp farming is one of the major sources of income. Now-a-days shrimp culture is facing many problems among them disease mitigation became major hurdle for the shrimp farmers. A study was done to evaluate the diseases affecting L.vannamei farming in coastal districts of Andhrapradesh, i.e., Gutur, Krishna, West Godavari and East Godavari. The summer crop was considered for the study during February -June 2019. The diseases that are responsible for huge losses in L. vannamei culture was found to be White Spot Syndrome Virus (WSSV), White Faecal Syndrome (WFS), Black Gill Disease (BGD), Loose Shell Syndrome (LSS), Running Mortality Syndrome (RMS), and Enterocytozoon Hepatopenaei (EHP) of all the selected 4 districts of the Andhra Pradesh. About 65% culture ponds of Guntur district, 69% in Krishna and 40% in West Godavari and 50% in East Godavari districts were affected by diseases. It was observed that, more disease related problems observed during the summer crop in all selected areas. The farms which implemented biosecurity measures, and maintained without any Dissolved Oxygen (DO) problems, were found to contain less diseases. Therefore it is suggested that by practicing better management practices (BMP) by following biosecurity measures, diseases can be prevented.