Loosening of the femoral component after use of the medullary-plug cementing technique. Follow-up note with a minimum five-year follow-up.

Harris, William H.; McGann, William A.

doi:10.2106/00004623-198668070-00014

Cited by 371 publications

(94 citation statements)

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“…The osteolysis group comprised subjects with current radiographic evidence of osteolysis and subjects who had previously undergone revision for confirmed aseptic loosening. The criteria of Harris and McGann and those of Harris and Penenberg were used to define loosening of the femoral or pelvic component, respectively (24,25). Control group subjects had no current evidence of osteolysis on plain anteroposterior and lateral radiographs of the hip obtained on the day of genotyping.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

Gordon¹,

Kiss-Tóth²,

Stockley³

et al. 2008

Arthritis & Rheumatism

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Objective. To determine whether osteolysis after total hip arthroplasty (THA) is associated with common polymorphisms within the genes encoding the interleukin-1 (IL-1) family and IL-6, and to determine whether polymorphisms that are associated with osteolysis affect in vitro messenger RNA (mRNA) expression in human peripheral blood mononuclear cells (PBMCs) in response to wear particles.Methods. Unrelated white subjects of North European descent (n ‫؍‬ 612) were recruited a mean of 11 years after cemented THA for primary osteoarthritis. Of these subjects, 272 had previous osteolysis and 340 had no radiographic evidence of osteolysis (control group). Genomic DNA was genotyped for the following singlenucleotide polymorphisms (SNPs): IL1A ؉4845, IL1B ؉3954, IL1B -3737, IL1B -511, IL1RA ؉2018, IL6 -174, IL6 -572, and IL6 -597. In a subset of 60 subjects, PBMCs were extracted and stimulated with titanium particles and/or endotoxin, and cytokine mRNA expression was measured using quantitative real-time reverse transcriptase-polymerase chain reaction.Results. The odds ratio (OR) for osteolysis associated with carriage of the IL1RA ؉2018C allele was 0.66 (95% confidence interval [95% CI] 0.48-0.91) (P ‫؍‬ 0.012). The remaining SNPs were not individually associated with osteolysis. The uncommon IL6 haplotype ؊174G/؊572G/؊597A (osteolysis group frequency 2.4%, control group frequency 0.8%) was associated with osteolysis (P ‫؍‬ 0.02, calculated using Haploview software). The IL1RA ؉2018CC genotype was associated with increased mRNA expression compared with the ؉2018TT genotype in both unstimulated and stimulated PBMCs (P ‫؍‬ 0.01 by analysis of variance, after Bonferroni correction).Conclusion. The IL1RA ؉2018C allele is associated with a decreased risk of osteolysis after THA and with increased IL-1 receptor antagonist mRNA expression in vitro. An uncommon haplotype within the promoter region of the gene for IL-6 is positively associated with osteolysis.

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Section: Methodsmentioning

confidence: 99%

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

Gordon¹,

Kiss-Tóth²,

Stockley³

et al. 2008

Arthritis & Rheumatism

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“…The degree of loosening on the radiographs was graded according to the criteria of Charnley, 17 Harris and McGann 18 and…”

Section: Methodsmentioning

confidence: 99%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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T he tissues surrounding 65 cemented and 36 cementless total joint replacements undergoing revision were characterised for cell types by immunohistochemistry and for cytokine expression by in situ hybridisation.We identified three distinct groups of revised implants: loose implants with ballooning radiological osteolysis, loose implants without osteolysis, and well-fixed implants. In the cemented series, osteolysis was associated with increased numbers of macrophages (

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“…The durability of cemented femoral resurfacing components is dependent on producing durable bonds between the implant and cement and between the cement and bone without excessive bone necrosis. 5,6 Numerous reports exist on cement technique and cement fixation of conventional total hip replacement prostheses, [7][8][9][10][11][12][13] on acetabular cup fixation, [14][15][16][17][18][19] and on cement fixation of total knee prostheses. [20][21][22][23] Cement penetration of 2-5 mm into bone is believed to be optimal for the fixation of components in cancellous bone.…”

Section: Introductionmentioning

confidence: 99%

Femoral cementing technique for hip resurfacing arthroplasty

Bitsch

Heisel

Silva

et al. 2007

Journal Orthopaedic Research

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The resurgence of metal-metal bearings has renewed interest in hip resurfacing, but a paucity of information exists regarding femoral cementing technique. We developed a laboratory model in which 72 open-cell foam specimens were used to simulate bone. Analyses of two cement viscosities, two foam porosities, and six cementing techniques were performed: manual cement application only, manual application and filling of one quarter of the component with cement, filling of half of the component, manual application and half component filling, full component filling, and manual application and full component filling. For manual application, cement was pressurized into the foam by rolling the finger tips. For component filling, a defined quantity of cement was poured into the component before pressing it onto the foam. Specimens were cut into quarters, and cement penetration was quantified in seven areas: top, chamfer, wall, interior area, and proximal, medial, and distal stem. The manual technique showed a 3-mm thick, even cement penetration of the outer fixation surface (top ¼ 26 AE 0 mm 2 , chamfer ¼ 14.9 AE 0.2 mm 2 , wall ¼ 55.6 AE 5.2 mm 2 ). None of the other techniques showed a significantly higher penetration in these areas. Large differences were found between all techniques at the medial stem (27.7 AE 17.5 mm 2 , p < 0.001) and the interior area (128.5 AE 69.6 mm 2 , p ¼ 0.013). An increasing degree of penetration occurred from manual cement application to manual application and full component filling. Sixteen specimens showed incomplete seating, which occurred with all techniques except the manual technique. The manual technique consistently gave an approximately 3-mm thick even cement penetration over the outer fixation area. Pouring any cement into the shell resulted in variable degrees of deeper penetration and a risk of incomplete seating, which have been associated with bone necrosis and early fracture.

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Loosening of the femoral component after use of the medullary-plug cementing technique. Follow-up note with a minimum five-year follow-up.

Cited by 371 publications

References 0 publications

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

Polymorphisms in the interleukin‐1 receptor antagonist and interleukin‐6 genes affect risk of osteolysis in patients with total hip arthroplasty

Cellular profile and cytokine production at prosthetic interfaces

Femoral cementing technique for hip resurfacing arthroplasty

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