Loperamid, an efficacious drug against the acanthocephalanMacracanthorhynchus hirudinaceus in pigs

Mehlhorn, Heinz; Taraschewski, Horst; Zhao, Bin; Raether, W.; Dunagan, T. T.

doi:10.1007/bf00932574

Cited by 9 publications

(3 citation statements)

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“…Ideally, compounds used for the treatment program should be based on previous analyses of the helminth spectrum present in the concerned animals (Roepstorff 1997) and should consider an alternative compound that is sufficiently active against adult Trichuris, or has a pronounced effect on Macracanthorhynchus hirundinaceus, such as fenbendazol (Mehlhorn et al 1992) or loperamid (Mehlhorn et al 1990). The use of the injectable drug doramectin (e.g.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of an in-feed preparation of ivermectin against helminths in the European wild boar

Fernández-de-Mera

Vicente

Gortázar

et al. 2004

Parasitology Research

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The wild boar is one of Europe's most popular game species and its densities are increasing. Management tools such as farm breeding, supplementary feeding, and translocations are more frequently employed and anthelmintics are increasingly used in game farms and translocations. Here, we report the results of a controlled slaughter study on the efficacy of an in-feed preparation of ivermectin in European wild boars naturally infected with various helminths. The efficacy of ivermectin against adult stages of Metastrongylus sp., Ascaris suum, Ascarops strongylina, Physocephalus sexalatus, and Simondsia paradoxa was 100%. Its efficacy against Oesophagostomum dentatum was 85.1%. There was no sufficient effect on Globocephalus urosubulatus, Trichuris suis, and Capillaria garfiai. The egg reduction in the treated group ( n=12) was 100% 6 days after the treatment. The importance of parasite surveillance and the application of anthelmintic treatments to wild boars in game farms or during translocations are discussed. We conclude that any attempt at helminth treatment in wild boars should consider the addition of a second compound with a more consistent effect on trichurids and other helminths.

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Section: Discussionmentioning

confidence: 99%

Efficacy of an in-feed preparation of ivermectin against helminths in the European wild boar

Fernández-de-Mera

Vicente

Gortázar

et al. 2004

Parasitology Research

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“…Numerous cases of peritonitis and even death have been reported in Asia as a result of complete penetration of the gut wall by the adult M. hirudinaceus worm in both humans [4] and pigs [5]. In fact, one large survey from China revealed over 200 cases of surgically diagnosed infection after operating for acute abdominal symptoms caused by intestinal perforations by this worm [6].…”

Section: Discussionmentioning

confidence: 99%

“…When infection with either M. ingens or M. hirudinaceus are diagnosed, good treatment data in humans are lacking. Based on a few human case reports, a few drugs have been recommended, including Pyrantel pamoate, Niclosamide, mebendazole, Ivermectin, Loperamid and piperazine citrate, with none emerging as the clear drug of choice [5,6,8]. While this patient was treated with mebendazole, albendazole may be a better choice based on treatment of related helminths.…”

Section: Discussionmentioning

confidence: 99%