1994
DOI: 10.1203/00006450-199403000-00016
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Loperamide Inhibits the Enhanced Intestinal Glucose Absorption of Cystic Fibrosis In Vitro

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Cited by 5 publications
(5 citation statements)
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“…Despite the rather similar molecular size of L‐rhamnose and xylose, the current results suggest that they are absorbed by different mechanisms, both accelerated in CF. The fact that other studies have shown an enhanced active intestinal transport of glucose in CF (1,2) and that the IP of xylose was increased in this study, supports the idea of a common or related transport system for the two sugars. It has been suggested that xylose uses the active transport system of glucose but has a lower affinity (33,34).…”
Section: Discussionsupporting
confidence: 89%
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“…Despite the rather similar molecular size of L‐rhamnose and xylose, the current results suggest that they are absorbed by different mechanisms, both accelerated in CF. The fact that other studies have shown an enhanced active intestinal transport of glucose in CF (1,2) and that the IP of xylose was increased in this study, supports the idea of a common or related transport system for the two sugars. It has been suggested that xylose uses the active transport system of glucose but has a lower affinity (33,34).…”
Section: Discussionsupporting
confidence: 89%
“…Several studies have provided evidence of abnormalities of the small intestine in patients with CF. These abnormalities include altered secretory function (1), enhanced active transport of glucose (1,2), alterations in amino acid absorption (3), and increased intestinal permeability (IP) (4‐8).…”
mentioning
confidence: 99%
“…We observed peak short‐circuit current responses to a stimulus of 45 mM glucose in mice, consistent with saturation of SGLT1‐faciliated glucose transport at 30–50 mM glucose in rat jejunum (Kellett & Helliwell, 2000 ). In Ussing chamber studies using human small intestine, active glucose transport was maximal at 35–65 mM luminal glucose (Hardcastle et al., 1994 ; Kroesen et al., 2002 ; Larsen et al., 2001 ; Puthanmadhom Narayanan et al., 2021 ). Regional luminal glucose concentrations measured in vivo via indwelling catheters ranged from 2 to 48 mM glucose, in rodents, rabbits and dogs fed standard laboratory diets (Ferraris et al., 1990 ), confirming that the glucose concentrations we used in Ussing experiments were physiological.…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that CFTR may affect absorptive processes in addition to its known effects on secretion. In jejunal biopsies from CF patients the Na ‡ -dependent absorption of sugars and amino acids is enhanced, a change that reflects an increase in the maximum capacity of the absorptive process (Baxter et al 1990;Hardcastle et al 1994). The development of transgenic CF mouse models has provided an opportunity to study the transport activity of CF intestine in more detail (Grubb & Gabriel 1997).…”
Section: Introductionmentioning
confidence: 99%