Lorazepam on visuo-motor co-ordination and visual function in man

Bell, Raoul; Dickie, D. S.; Stewart-Jones, J. H.; Turner, Paul

doi:10.1111/j.2042-7158.1973.tb09126.x

Cited by 26 publications

(6 citation statements)

References 3 publications

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“…After a 2.0 mg dose of lorazepam tracking in the handeye coordination test (Bell et al, 1973), flicker fusion discrimination, disc-dotting scores and reaction times (Hedges et al, 1971) were significantly impaired, the maximum effect being seen mostly at 4 to 6 h after administration. The same investigators noticed that the effects of 51 lorazepam (1 mg) were considerably less severe although still measurable.…”

Section: Effects Of Lorazepammentioning

confidence: 99%

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Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Seppala¹,

Korttila²,

Häkkinen³

et al. 1976

Brit J Clinical Pharma

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1 Psychomotor skills and visual functions related to driving were measured double-blind cross-over in ten healthy volunteers before, and 1, 3, 5 and 7 h after a single oral administration of diazepam (10 mg), medazepam (15 mg) or lorazepam (2.5 mg). The late effects of lorazepam were tested in seven other subjects 12 and 24 h after the administration. 2 Lorazepam impaired almost all the measured skills more (P < 0.05 to 0.001) than diazepam, medazepam or the placebo. The lorazepam impairment of reactive skills and flicker fusion discrimination remained statistically significant (P < 0.05) for as long as 12 h. Medazepam impaired only reactive skills and flicker fusion, the latter remaining impaired (P < 0.05) for as long as 5 h after the administration. The magnitude and duration of the effects of diazepam were intermediate between those of lorazepam and medazepam. Diazepam impaired perceptual speed and reactive and co-ordinative skills as well as flicker fusion discrimination and visual parameters related to driving. Slight impairments in performance were measurable for up to 5 h after administration but at 7 h the results resembled those measured after the placebo. 3 The lack of alterations in adaptation to darkness, sensitivity to brightness or visual discrimination ability in bright counterlight at a time when flicker fusion discrimination was severely depressed suggests that an impaired ability to discriminate flickering light is of no or little clinical significance to driving ability. 4 It is concluded that patients receiving a 2.5 mg dose of lorazepam should not drive or operate machinery for 24 h after the administration. After diazepam (10 mg) or medazepam (15 mg) patients should refrain from driving or participating in skilled performances for only 5 to 7 hours.

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Section: Effects Of Lorazepammentioning

confidence: 99%

“…These studies indicate that diazepam impairs driving skills for a variable length of time depending on the dose and the mode of administration. Hedges, Turner & Harry (1971) and Bell, Dickie, Steward-Jones & Turner (1973) …”

Section: Introductionmentioning

confidence: 99%

Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Seppala¹,

Korttila²,

Häkkinen³

et al. 1976

Brit J Clinical Pharma

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“…It has marked sedative properties (Seppala, Kortilla, Hakkinen & Linnoila, 1976) making it clinically useful as a hypnotic and surgical premedication (Norris & Wallace, 1971;Globus, Phoebus, Humphries, Boyd, Gaffney & Gaffney, et al, 1974;Straughan, 1979). At doses between 1-4 mg lorazepam has been shown to impair performance on 0306-5251/80/080145-06 $01.00 analogues ofcar driving (Sappala et al, 1976), reaction time (Harry & Richards, 1972;Turner, 1973), flicker fusion frequency (Hedges, Turner & Harry, 1971;Turner, 1973;Farhoumand, Harrison, Pare, Turner & Wynn, 1979) and sensori-motor coordination (Bell, Dickie, Stewart-Jones & Turner, 1973 …”

Section: Introductionmentioning

confidence: 99%

The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.

Hindmarch¹,

Gudgeon²

1980

Brit J Clinical Pharma

127

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1 Laboratory tests of psychomotor performance and ‘on road’ assessments of car handling ability were made following repeated doses of clobazam 10 mg three times daily, lorazepam 1 mg three times daily and matching placebo 1 capsule three times daily. 2 Both active compounds produced on impairment, compared to placebo, in some mental arithmetic and letter cancellation tasks, but these effects were neither widespread nor consistent. 3 Lorazepam produced a significant impairment of car driving tasks and analogue rating scales of subjective alertness. The pronounced sedative activity of the drug was also shown in the verbal reports of side effects and in indices of early morning sedation derived from the Leeds Sleep Evaluation Questionnaire. 4 Clobazam did not produce either the objective, or the subjective impairment of performance and alertness found with lorazepam. 5 The results taken as a whole show important differences between the 1,4 benzodiazepine, lorazepam, and the 1,5 benzodiazepine, clobazam, in their effects on the integrity of psychomotor performance related to car driving ability.

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“…Practolol penetrates the brain to only a small extent but appears to be effective in treatment of anxiety (Bonn, Turner & Hicks, 1972), which suggests a peripheral, rather than central, mode of action. We have examined the effect of propranolol in therapeutic doses in normal subjects to determine if evidence of a central nervous effect could be detected on reaction time and on a test of hand-eye co-ordination which has previously been shown to be sensitive to the effect of some centrally acting drugs including promethazine (Molson, Mackay, Smart & Turner, 1966) and lorazepam (Bell, Dickie, Stewart-Jones & Turner, 1973). In any study of centrally acting drugs in man involving a response to a visual stimulus, the possibility of a drug effect on the peripheral visual apparatus must be considered, and therefore, in addition to these tests of central nervous function, tests of visual activity were also performed.…”

Section: Propranolol On Tests Of Visual Function and Central Nervous mentioning

confidence: 99%

Propranolol on Tests of Visual Function and Central Nervous Activity

Bryan

Efiong

Stewart-Jones

et al. 1974

Brit J Clinical Pharma

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Lorazepam on visuo-motor co-ordination and visual function in man

Abstract: Astereotaxic atlas of the forebrain and 127, 46-50.The Rat Brain. Baltimore: Williams and Wilkins. lower parts of the brain stem. Actapharmac. lox., 31, Suppl., 1, 26. research, 11. Amsterdam: Elsevier.

Cited by 26 publications

References 3 publications

Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.

Propranolol on Tests of Visual Function and Central Nervous Activity

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